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Institution

University of Louisville

EducationLouisville, Kentucky, United States
About: University of Louisville is a education organization based out in Louisville, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 24600 authors who have published 49248 publications receiving 1573346 citations. The organization is also known as: UofL.


Papers
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Journal ArticleDOI
J. P. Lees1, V. Poireau1, V. Tisserand1, E. Grauges2  +308 moreInstitutions (73)
TL;DR: In this article, the authors presented a search for a dark photon in the reaction e^{+}e^{-}→γA^{'], A^{'}→e''+''e''-e''−γA''−E''−μ'' −μ'' -E'' −γA''.
Abstract: Dark sectors charged under a new Abelian interaction have recently received much attention in the context of dark matter models. These models introduce a light new mediator, the so-called dark photon (A^{'}), connecting the dark sector to the standard model. We present a search for a dark photon in the reaction e^{+}e^{-}→γA^{'}, A^{'}→e^{+}e^{-}, μ^{+}μ^{-} using 514 fb^{-1} of data collected with the BABAR detector. We observe no statistically significant deviations from the standard model predictions, and we set 90% confidence level upper limits on the mixing strength between the photon and dark photon at the level of 10^{-4}-10^{-3} for dark photon masses in the range 0.02-10.2 GeV. We further constrain the range of the parameter space favored by interpretations of the discrepancy between the calculated and measured anomalous magnetic moment of the muon.

436 citations

Journal ArticleDOI
Mattia Negrello1, Rosalind Hopwood1, G. de Zotti, Asantha Cooray2, Aprajita Verma3, J. J. Bock4, J. J. Bock5, David T. Frayer6, Mark Gurwell7, Alain Omont8, R. Neri, Helmut Dannerbauer9, Lerothodi Leonard Leeuw10, Lerothodi Leonard Leeuw11, Elizabeth J. Barton2, Jeff Cooke2, Jeff Cooke4, S. Kim2, E. da Cunha12, Giulia Rodighiero13, Peter Timothy Cox, D. G. Bonfield14, Matt J. Jarvis14, Steve Serjeant1, Rob Ivison15, Simon Dye16, Itziar Aretxaga17, David H. Hughes17, Edo Ibar, Frank Bertoldi18, Ivan Valtchanov19, Stephen Anthony Eales16, Loretta Dunne20, Simon P. Driver21, Robbie Richard Auld16, S. Buttiglione, Antonio Cava22, Antonio Cava23, C. A. Grady24, David L. Clements25, Aliakbar Dariush16, Jacopo Fritz26, Denis Hill21, J. B. Hornbeck27, Lee S. Kelvin21, Guilaine Lagache28, M. López-Caniego23, J. González-Nuevo, Steve Maddox20, Enzo Pascale16, Michael Pohlen16, E. E. Rigby20, Aaron S. G. Robotham21, Chris Simpson29, Daniel J. Smith20, P. Temi30, Mark Thompson14, B. E. Woodgate24, Donald G. York31, James E. Aguirre32, Alexandre Beelen28, Andrew Blain4, Andrew J. Baker33, Mark Birkinshaw34, R. Blundell7, Charles M. Bradford4, Charles M. Bradford5, Denis Burgarella35, Luigi Danese, James Dunlop, S. Fleuren36, Jason Glenn37, Andrew I. Harris38, Julia Kamenetzky37, Roxana Lupu32, Ronald J. Maddalena6, Barry F. Madore39, P. R. Maloney37, Hideo Matsuhara40, M. J. Michaowski15, Eric J. Murphy, B. J. Naylor5, Hien Nguyen5, Cristina Popescu41, Steve Rawlings3, Dimitra Rigopoulou3, Dimitra Rigopoulou42, Douglas Scott43, Kimberly S. Scott32, Mark Seibert39, Ian Smail44, Richard J. Tuffs45, Joaquin Vieira4, P. van der Werf46, P. van der Werf15, Jonas Zmuidzinas5, Jonas Zmuidzinas4 
05 Nov 2010
TL;DR: Early data from the Herschel Astrophysical Terahertz Large Area Survey are used to demonstrate that wide-area submillimeter surveys can simply and easily detect strong gravitational lensing events, with close to 100% efficiency.
Abstract: Gravitational lensing is a powerful astrophysical and cosmological probe and is particularly valuable at submillimeter wavelengths for the study of the statistical and individual properties of dusty star-forming galaxies. However, the identification of gravitational lenses is often time-intensive, involving the sifting of large volumes of imaging or spectroscopic data to find few candidates. We used early data from the Herschel Astrophysical Terahertz Large Area Survey to demonstrate that wide-area submillimeter surveys can simply and easily detect strong gravitational lensing events, with close to 100% efficiency.

436 citations

Journal ArticleDOI
TL;DR: Inhaled nitric oxide therapy improves the pulmonary outcome for premature infants who are at risk for bronchopulmonary dysplasia when it is started between 7 and 21 days of age and has no apparent short-term adverse effects.
Abstract: Background Bronchopulmonary dysplasia in premature infants is associated with prolonged hospitalization, as well as abnormal pulmonary and neurodevelopmental outcome. In animal models, inhaled nitric oxide improves both gas exchange and lung structural development, but the use of this therapy in infants at risk for bronchopulmonary dysplasia is controversial. Methods We conducted a randomized, stratified, double-blind, placebo-controlled trial of inhaled nitric oxide at 21 centers involving infants with a birth weight of 1250 g or less who required ventilatory support between 7 and 21 days of age. Treated infants received decreasing concentrations of nitric oxide, beginning at 20 ppm, for a minimum of 24 days. The primary outcome was survival without bronchopulmonary dysplasia at 36 weeks of postmenstrual age. Results Among 294 infants receiving nitric oxide and 288 receiving placebo birth weight (766 g and 759 g, respectively), gestational age (26 weeks in both groups), and other characteristics were sim...

436 citations

Journal ArticleDOI
TL;DR: It is proposed that NO interacts with components of the electron transport chain and/or the mitochondrial permeability transition pore to limit post-ischemic myocardial damage, and that this action potentially provides a fundamental molecular explanation for the mechanism of NO-mediated cardioprotection.

436 citations

Journal ArticleDOI
TL;DR: The data indicate the critical role of mitochondrial ROS in cardiac hypertrophy and failure and support the potential use of mitochondrial-targeted antioxidants for prevention and treatment of hypertensive cardiomyopathy.
Abstract: Rationale: Mitochondrial dysfunction has been implicated in several cardiovascular diseases; however, the roles of mitochondrial oxidative stress and DNA damage in hypertensive cardiomyopathy are not well understood. Objective: We evaluated the contribution of mitochondrial reactive oxygen species (ROS) to cardiac hypertrophy and failure by using genetic mouse models overexpressing catalase targeted to mitochondria and to peroxisomes. Methods and Results: Angiotensin II increases mitochondrial ROS in cardiomyocytes, concomitant with increased mitochondrial protein carbonyls, mitochondrial DNA deletions, increased autophagy and signaling for mitochondrial biogenesis in hearts of angiotensin II–treated mice. The causal role of mitochondrial ROS in angiotensin II–induced cardiomyopathy is shown by the observation that mice that overexpress catalase targeted to mitochondria, but not mice that overexpress wild-type peroxisomal catalase, are resistant to cardiac hypertrophy, fibrosis and mitochondrial damage induced by angiotensin II, as well as heart failure induced by overexpression of Gαq. Furthermore, primary damage to mitochondrial DNA, induced by zidovudine administration or homozygous mutation of mitochondrial polymerase γ, is also shown to contribute directly to the development of cardiac hypertrophy, fibrosis and failure. Conclusions: These data indicate the critical role of mitochondrial ROS in cardiac hypertrophy and failure and support the potential use of mitochondrial-targeted antioxidants for prevention and treatment of hypertensive cardiomyopathy.

435 citations


Authors

Showing all 24802 results

NameH-indexPapersCitations
Robert M. Califf1961561167961
Aaron R. Folsom1811118134044
Yang Gao1682047146301
Stephen J. O'Brien153106293025
James J. Collins15166989476
Anthony E. Lang149102895630
Sw. Banerjee1461906124364
Hermann Kolanoski145127996152
Ferenc A. Jolesz14363166198
Daniel S. Berman141136386136
Aaron T. Beck139536170816
Kevin J. Tracey13856182791
C. Dallapiccola1361717101947
Michael I. Posner134414104201
Alan Sher13248668128
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202373
2022249
20212,489
20202,234
20192,193
20182,153