University of Louisville

About: University of Louisville is a education organization based out in Louisville, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 24600 authors who have published 49248 publications receiving 1573346 citations. The organization is also known as: UofL.

A new urban landscape in East?Southeast Asia, 2000?2010

Abstract: East–Southeast Asia is currently one of the fastest urbanizing regions in the world, with countries such as China climbing from 20 to 50 percent urbanized in just a few decades. By 2050, these countries are projected to add 1 billion people, with 90 percent of that growth occurring in cities. This population shift parallels an equally astounding amount of built-up land expansion. However, spatially-and temporally detailed information on regional-scale changes in urban land or population distribution do not exist; previous efforts have been either sample-based, focused on one country, or drawn conclusions from datasets with substantial temporal/spatial mismatch and variability in urban definitions. Using consistent methodology, satellite imagery and census data for greater than1000 agglomerations in the East–Southeast Asian region, the authors show that urban land increased to greater than 22 percent between 2000 and 2010 (from 155 000 to 189 000 square kilometers), an amount equivalent to the area of Taiwan, while urban populations climbed greater than 31 percent (from 738 to 969 million). Although urban land expanded at unprecedented rates, urban populations grew more rapidly, resulting in increasing densities for the majority of urban agglomerations, including those in both more developed (Japan, South Korea) and industrializing nations (China, Vietnam, Indonesia). This result contrasts previous sample-based studies, which conclude that cities are universally declining in density. The patterns and rates of change uncovered by these datasets provide a unique record of the massive urban transition currently underway in East–Southeast Asia that is impacting local-regional climate, pollution levels, water quality and availability, arable land, as well as the livelihoods and vulnerability of populations in the region.

The RASSF1A tumor suppressor

Abstract: RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor suppressor whose inactivation is implicated in the development of many human cancers. Although it can be inactivated by gene deletion or point mutations, the most common contributor to loss or reduction of RASSF1A function is transcriptional silencing of the gene by inappropriate promoter methylation. This epigenetic mechanism can inactivate numerous tumor suppressors and is now recognized as a major contributor to the development of cancer. RASSF1A lacks apparent enzymatic activity but contains a Ras association (RA) domain and is potentially an effector of the Ras oncoprotein. RASSF1A modulates multiple apoptotic and cell cycle checkpoint pathways. Current evidence supports the hypothesis that it serves as a scaffold for the assembly of multiple tumor suppressor complexes and may relay pro-apoptotic signaling by K-Ras.

Self-efficacy and self-concept as predictors of college students' academic performance

Abstract: Social cognitive theory suggests that self-constructs are better predictors when the specificity levels of self-constructs (as predictors) and the criterion variable closely correspond. In this study it was examined whether self-constructs measured at an intermediate level of specificity better correspond with the criterion variable (course grades: an intermediate level of specificity) than general self-constructs or specific self-constructs. Self-constructs in this study included self-efficacy and self-concept at varying degrees of specificity: general self-efficacy, academic self-efficacy, specific self-efficacy, academic self-concept, and specific self-concept. College students (N = 230) in general education courses voluntarily completed the three self-efficacy measures and the two self-concept measures. Results of correlation and simultaneous multiple regression analyses indicated that the closer the level of specificity of self-efficacy and self-concept, the stronger the relationship between the two constructs. Both academic self-concept and specific self-concept were significant predictors of term grades. In addition, academic self-concept was also a significant predictor, whereas neither general self-efficacy nor academic self-efficacy was significant. Measurement issues and implications of the findings are discussed. © 2005 Wiley Periodicals, Inc. Psychol Schs 42: 197–205, 2005.

Mitochondrial PKCε and MAPK Form Signaling Modules in the Murine Heart Enhanced Mitochondrial PKCε-MAPK Interactions and Differential MAPK Activation in PKCε-Induced Cardioprotection

Abstract: Although activation of protein kinase C (PKC) e and mitogen-activated protein kinases (MAPKs) are known to play crucial roles in the manifestation of cardioprotection, the spatial organization of P...