Institution
University of Luxembourg
Education•Luxembourg, Luxembourg•
About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Population & European union. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.
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TL;DR: In this paper, the rational points on a certain elliptic surface over P^1 of positive rank parameterize a family of genus-2 curves over Q whose Jacobians each have 128 rational torsion points.
Abstract: We construct examples of families of curves of genus 2 or 3 over Q whose Jacobians split completely and have various large rational torsion subgroups. For example, the rational points on a certain elliptic surface over P^1 of positive rank parameterize a family of genus-2 curves over Q whose Jacobians each have 128 rational torsion points. Also, we find the genus-3 curve 15625(X^4 + Y^4 + Z^4) - 96914(X^2 Y^2 + X^2 Z^2 + Y^2 Z^2) = 0, whose Jacobian has 864 rational torsion points.
This paper has appeared in Forum Math. 12 (2000) 315-364.
109 citations
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TL;DR: In this paper, the authors raise critical questions about the notion of learning, the language of learning and the discourse of learning in the context of data-driven learning, arguing that the analytical and critical device used is the idea of learning.
Abstract: In this article, the author raises critical questions about the notion of ‘learning’, the language of ‘learning’ and the discourse of ‘learning’. The analytical and critical device used is the idea...
109 citations
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TL;DR: This work describes both the instability mechanism leading to phase separation and the resulting phase coexistence of active Ornstein-Uhlenbeck particles, and probes how, in the stationary state, AOUPs depart from their thermal equilibrium limit by investigating the emergence of ratchet currents and entropy production.
Abstract: We study the statistical properties of active Ornstein-Uhlenbeck particles (AOUPs). In this simplest of models, the Gaussian white noise of overdamped Brownian colloids is replaced by a Gaussian colored noise. This suffices to grant this system the hallmark properties of active matter, while still allowing for analytical progress. We study in detail the steady-state distribution of AOUPs in the small persistence time limit and for spatially varying activity. At the collective level, we show AOUPs to experience motility-induced phase separation both in the presence of pairwise forces or due to quorum-sensing interactions. We characterize both the instability mechanism leading to phase separation and the resulting phase coexistence. We probe how, in the stationary state, AOUPs depart from their thermal equilibrium limit by investigating the emergence of ratchet currents and entropy production. In the small persistence time limit, we show how fluctuation-dissipation relations are recovered. Finally, we discuss how the emerging properties of AOUPs can be characterized from the dynamics of their collective modes.
109 citations
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TL;DR: The efficiency and scalability of fastGapFill are demonstrated, a computationally efficient tractable extension to the COBRA toolbox that permits the identification of candidate missing knowledge from a universal biochemical reaction database for a given metabolic reconstruction.
Abstract: Motivation: Genome-scale metabolic reconstructions summarize current knowledge about a target organism in a structured manner and as such highlight missing information. Such gaps can be filled algorithmically. Scalability limitations of available algorithms for gap filling hinder their application to compartmentalized reconstructions. Results: We present FASTGAPFILL, a computationally efficient tractable extension to the COBRA toolbox that permits the identification of candidate missing knowledge from a universal biochemical reaction database (e.g. Kyoto Encyclopedia of Genes and Genomes) for a given (compartmentalized) metabolic reconstruction. The stoichiometric consistency of the universal reaction database and of the metabolic reconstruction can be tested for permitting the computation of biologically more relevant solutions. We demonstrate the efficiency and scalability of FASTGAPFILL on a range of metabolic reconstructions. Availability and implementation: FASTGAPFILL is freely available from
109 citations
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TL;DR: Results suggest that the microgliosis intensity during PD might depend on the type of α-synuclein protein implicated, and mutated forms are more potent microglial stimulators than wild-type α- synuclein.
Abstract: Parkinson’s disease (PD) is histologically described by the deposition of α-synuclein, whose accumulation in Lewy bodies causes dopaminergic neuronal death. Although most of PD cases are sporadic, point mutations of the gene encoding the α-synuclein protein cause inherited forms of PD. There are currently six known point mutations that result in familial PD. Oxidative stress and neuroinflammation have also been described as early events associated with dopaminergic neuronal degeneration in PD. Though it is known that microglia are activated by wild-type α-synuclein, little is known about its mutated forms and the signaling cascades responsible for this microglial activation. The present study was designed to investigate consequences of wild-type and mutant α-synuclein (A53T, A30P and E46K) exposure on microglial reactivity. Interestingly, we described that α-synuclein-induced microglial reactivity appeared to be peptide-dependent. Indeed, the A53T protein activated more strongly microglia than the wild-type α-synuclein and other mutants. This A53T-induced microglial reactivity mechanism was found to depend on phosphorylation mechanisms mediated by MAPKs and on successive NFkB/AP-1/Nrf2 pathways activation. These results suggest that the microgliosis intensity during PD might depend on the type of α-synuclein protein implicated. Indeed, mutated forms are more potent microglial stimulators than wild-type α-synuclein. Based on these data, anti-inflammatory and antioxidant therapeutic strategies may be valid in order to reduce microgliosis but also to subsequently slow down PD progression, especially in familial cases.
109 citations
Authors
Showing all 4893 results
Name | H-index | Papers | Citations |
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Jun Wang | 166 | 1093 | 141621 |
Leroy Hood | 158 | 853 | 128452 |
Andreas Heinz | 108 | 1078 | 45002 |
Philippe Dubois | 101 | 1098 | 48086 |
John W. Berry | 97 | 351 | 52470 |
Michael Müller | 91 | 333 | 26237 |
Bart Preneel | 82 | 844 | 25572 |
Bjorn Ottersten | 81 | 1058 | 28359 |
Sander Kersten | 79 | 246 | 23985 |
Alexandre Tkatchenko | 77 | 271 | 26863 |
Rudi Balling | 75 | 238 | 19529 |
Lionel C. Briand | 75 | 380 | 24519 |
Min Wang | 72 | 716 | 19197 |
Stephen H. Friend | 70 | 184 | 53422 |
Ekhard K. H. Salje | 70 | 581 | 19938 |