University of Luxembourg

About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Context (language use) & Computer science. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.

On functional form representation of multi-output production technologies

Abstract: The introduction of directional distance functions has given researchers an alternative to Shephard distance functions. In this paper we conduct a Monte Carlo study to investigate the performance of distance functions as an approximation for models of technology. Our results indicate that quadratic representations of technology have better approximation properties than translog parameterizations.

CHD2 variants are a risk factor for photosensitivity in epilepsy

Abstract: Photosensitivity is a heritable abnormal cortical response to flickering light, manifesting as particular electroencephalographic changes, with or without seizures. Photosensitivity is prominent in a very rare epileptic encephalopathy due to de novo CHD2 mutations, but is also seen in epileptic encephalopathies due to other gene mutations. We determined whether CHD2 variation underlies photosensitivity in common epilepsies, specific photosensitive epilepsies and individuals with photosensitivity without seizures. We studied 580 individuals with epilepsy and either photosensitive seizures or abnormal photoparoxysmal response on electroencephalography, or both, and 55 individuals with photoparoxysmal response but no seizures. We compared CHD2 sequence data to publicly available data from 34 427 individuals, not enriched for epilepsy. We investigated the role of unique variants seen only once in the entire data set. We sought CHD2 variants in 238 exomes from familial genetic generalized epilepsies, and in other public exome data sets. We identified 11 unique variants in the 580 individuals with photosensitive epilepsies and 128 unique variants in the 34 427 controls: unique CHD2 variation is over-represented in cases overall (P = 2.17 × 10(-5)). Among epilepsy syndromes, there was over-representation of unique CHD2 variants (3/36 cases) in the archetypal photosensitive epilepsy syndrome, eyelid myoclonia with absences (P = 3.50 × 10(-4)). CHD2 variation was not over-represented in photoparoxysmal response without seizures. Zebrafish larvae with chd2 knockdown were tested for photosensitivity. Chd2 knockdown markedly enhanced mild innate zebrafish larval photosensitivity. CHD2 mutation is the first identified cause of the archetypal generalized photosensitive epilepsy syndrome, eyelid myoclonia with absences. Unique CHD2 variants are also associated with photosensitivity in common epilepsies. CHD2 does not encode an ion channel, opening new avenues for research into human cortical excitability.

Methods for mitigating disruptions in complex supply chain structures: A systematic literature review.

Abstract: Supply chain risk management is extremely important for the success of a company. Due to the increasing complexity of supply chains, avoiding and mitigating the effects of disruptions is very chall...

Strategies to mitigate aliasing of loading signals while estimating GPS frame parameters

Abstract: Although GNSS techniques are theoretically sensitive to the Earth center of mass, it is often preferable to remove intrinsic origin and scale information from the estimated station positions since they are known to be affected by systematic errors. This is usually done by estimating the parameters of a linearized similarity transformation which relates the quasi-instantaneous frames to a long-term frame such as the International Terrestrial Reference Frame (ITRF). It is well known that non-linear station motions can partially alias into these parameters. We discuss in this paper some procedures that may allow reducing these aliasing effects in the case of the GPS techniques. The options include the use of well-distributed sub-networks for the frame transformation estimation, the use of site loading corrections, a modification of the stochastic model by downweighting heights, or the joint estimation of the low degrees of the deformation field. We confirm that the standard approach consisting of estimating the transformation over the whole network is particularly harmful for the loading signals if the network is not well distributed. Downweighting the height component, using a uniform sub-network, or estimating the deformation field perform similarly in drastically reducing the amplitude of the aliasing effect. The application of these methods to reprocessed GPS terrestrial frames permits an assessment of the level of agreement between GPS and our loading model, which is found to be about 1.5 mm WRMS in height and 0.8 mm WRMS in the horizontal at the annual frequency. Aliased loading signals are not the main source of discrepancies between loading displacement models and GPS position time series.