Institution
University of Luxembourg
Education•Luxembourg, Luxembourg•
About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Population & European union. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.
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18 Mar 2015TL;DR: In this article, the exact rates of convergence in total variation associated with Nualart and Peccati's "fourth moment theorem" were derived. But the convergence rate of the fourth moment theorem is not known.
Abstract: We compute the exact rates of convergence in total variation associated with the ‘fourth moment theorem’ by Nualart and Peccati (2005), stating that a sequence of random variables living in a fixed Wiener chaos verifies a central limit theorem (CLT) if and only if the sequence of the corresponding fourth cumulants converges to zero. We also provide an explicit illustration based on the Breuer-Major CLT for Gaussian-subordinated random sequences.
99 citations
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TL;DR: In this first pathoanatomical study of the brain of an A30P mutation carrier, neuronal loss in the substantia nigra, locus coeruleus, and dorsal motor vagal nucleus is observed, as well as widespread occurrence of alpha‐synuclein immunopositive Lewy bodies, Lewy neurites, and glial aggregates.
Abstract: Familial Parkinson disease (PD) due to the A30P mutation in the SNCA gene encoding alpha-synuclein is clinically associated with PD symptoms. In this first pathoanatomical study of the brain of an A30P mutation carrier, we observed neuronal loss in the substantia nigra, locus coeruleus, and dorsal motor vagal nucleus, as well as widespread occurrence of alpha-synuclein immunopositive Lewy bodies, Lewy neurites, and glial aggregates. Alpha-synuclein aggregates ultrastructurally resembled Lewy bodies, and biochemical analyses disclosed a significant load of insoluble alpha-synuclein, indicating neuropathological similarities between A30P disease patients and idiopathic PD, with a more severe neuropathology in A30P carriers.
99 citations
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TL;DR: A close look is taken at developments in the mutli-omic analyses and the use of mass spectrometry to investigate the exchange of metabolites between the host and the microbiome as well as the environment within the microbiome.
99 citations
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TL;DR: The hypothesis that cytokine receptor·Janus kinase complexes can be regarded as receptor tyrosine kinases is supported by the data observed, which show that Jak1 remains a membrane-localized protein after cytokine stimulation.
99 citations
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TL;DR: The findings demonstrate the decay of passively acquired MV antibodies occurred even more rapidly than expected resulting in susceptibility to MV in most of the 4‐month‐old infants in Nigeria and suggest the use of alternative vaccination strategies in developing countries to possibly reduce the window of susceptibility against measles.
Abstract: Background. In developing countries vaccination against measles virus (MV) is generally administered at 9 months of age, although it is well-documented that protection of most infants by passively acquired maternal MV antibodies is waning before immunization is given. The purpose of this study was to investigate the decay of maternally derived MV antibodies in Nigerian infants as well as to compare a German and Nigerian cohort of paired mothers and newborns regarding the placental transfer efficiency of MV-specific IgG and total IgG antibodies. Methods. MV-specific IgG antibodies were measured with a commercially available MV-enzyme-linked immunosorbent assay, a recombinant hemagglutinin enzyme-linked immunosorbent assay as well as a neutralization assay. Total IgG values were determined with a standard immunoturbidimetric test. Results. Anti-MV IgG titers were twice as high in German newborns as in Nigerian newborns. An increased concentration of immunoglobulins transferred via the placenta was found only in the German cohort. High concentrations of total maternal IgG reduced the concentration of MV-specific as well as total IgG that crossed the placenta. Furthermore only 17% of the 4-monthold Nigerian infants were still protected against measles. Antibodies had a biologic half-life of 33 days and a biochemical half-life of 48 days. Conclusions. Our findings demonstrate that the decay of passively acquired MV antibodies occurred even more rapidly than expected resulting in susceptibility to MV in most of the 4-month-old infants in Nigeria. Furthermore transfer of maternal anti-MV IgG and total IgG antibodies to the newborn was more efficient in the German cohort compared with the Nigerian group. These findings suggest the use of alternative vaccination strategies in developing countries to possibly reduce the window of susceptibility against measles.
99 citations
Authors
Showing all 4893 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jun Wang | 166 | 1093 | 141621 |
Leroy Hood | 158 | 853 | 128452 |
Andreas Heinz | 108 | 1078 | 45002 |
Philippe Dubois | 101 | 1098 | 48086 |
John W. Berry | 97 | 351 | 52470 |
Michael Müller | 91 | 333 | 26237 |
Bart Preneel | 82 | 844 | 25572 |
Bjorn Ottersten | 81 | 1058 | 28359 |
Sander Kersten | 79 | 246 | 23985 |
Alexandre Tkatchenko | 77 | 271 | 26863 |
Rudi Balling | 75 | 238 | 19529 |
Lionel C. Briand | 75 | 380 | 24519 |
Min Wang | 72 | 716 | 19197 |
Stephen H. Friend | 70 | 184 | 53422 |
Ekhard K. H. Salje | 70 | 581 | 19938 |