Institution
University of Luxembourg
Education•Luxembourg, Luxembourg•
About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Population & European union. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.
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TL;DR: The aim of this review is to give a thorough overview of the commonly used fibroblast markers in the field and their various strengths and, more importantly, their weaknesses, as well as to highlight potential future avenues for CAF identification and targeting.
Abstract: The tumor microenvironment has been identified as one of the driving factors of tumor progression and invasion. Inside this microenvironment, cancer-associated fibroblasts (CAFs), a type of perpetually activated fibroblasts, have been implicated to have a strong tumor-modulating effect and play a key role in areas such as drug resistance. Identification of CAFs has typically been carried based on the expression of various "CAF markers", such as fibroblast activation protein alpha (FAP) and alpha smooth muscle actin (αSMA), which separates them from the larger pool of fibroblasts present in the body. However, as outlined in this Review, the expression of various commonly used fibroblast markers is extremely heterogeneous and varies strongly between different CAF subpopulations. As such, novel selection methods based on cellular function, as well as further characterizing research, are vital for the standardization of CAF identification in order to improve the cross-applicability of different research studies in the field. The aim of this review is to give a thorough overview of the commonly used fibroblast markers in the field and their various strengths and, more importantly, their weaknesses, as well as to highlight potential future avenues for CAF identification and targeting.
307 citations
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TL;DR: An up-to-date review on the coupling of polarization with optical properties in ferroelectrics, highlighting several important issues and parameters, such as the role of domain walls, ways to tune the bandgap, consequences arising from the polarization switchability, and the roles of defects and contact electrodes, as well as the downscaling effects.
Abstract: Ferroelectrics carry a switchable spontaneous electric polarization. This polarization is usually coupled to strain, making ferroelectrics good piezoelectrics. When coupled to magnetism, they become so-called multiferroic systems, a field that has been widely investigated since 2003. While ferroelectrics are birefringent and non-linear optically transparent materials, the coupling of polarization with optical properties has received, since 2009, renewed attention, triggered notably by low-bandgap ferroelectrics suitable for sunlight spectrum absorption and original photovoltaic effects. Consequently, power conversion efficiencies up to 8.1% were recently achieved and values of 19.5% were predicted, making photoferroelectrics promising photovoltaic alternatives. This article aims at providing an up-to-date review on this emerging and rapidly progressing field by highlighting several important issues and parameters, such as the role of domain walls, ways to tune the bandgap, consequences arising from the polarization switchability, and the role of defects and contact electrodes, as well as the downscaling effects. Beyond photovoltaicity, other polarization-related processes are also described, like light-induced deformation (photostriction) or light-assisted chemical reaction (photostriction). It is hoped that this overview will encourage further avenues to be explored and challenged and, as a byproduct, will inspire other research communities in material science, e.g., so-called hybrid halide perovskites.
306 citations
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TL;DR: This work proposes an algorithm to break-down the large problem size when many periods have to be considered, and the effectiveness of the approach and the significant benefits obtained by static and dynamic reconfiguration options in terms of DG hosting capacity are demonstrated using a modified benchmark distribution system.
Abstract: As the amount of distributed generation (DG) is growing worldwide, the need to increase the hosting capacity of distribution systems without reinforcements is becoming nowadays a major concern. This paper explores how the DG hosting capacity of active distribution systems can be increased by means of network reconfiguration, both static, i.e., grid reconfiguration at planning stage, and dynamic, i.e., grid reconfiguration using remotely controlled switches as an active network management (ANM) scheme. The problem is formulated as a mixed-integer, nonlinear, multi-period optimal power flow (MP-OPF) which aims to maximize the DG hosting capacity under thermal and voltage constraints. This work further proposes an algorithm to break-down the large problem size when many periods have to be considered. The effectiveness of the approach and the significant benefits obtained by static and dynamic reconfiguration options in terms of DG hosting capacity are demonstrated using a modified benchmark distribution system.
305 citations
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TL;DR: This work highlights analytical and bioanalytical approaches to isolating, characterizing, and tracking groups of chemicals of concern in complex matrices and proposes techniques that combine chemical analysis and bioassays to facilitate the identification of mixtures of chemicals that pose a combined risk.
Abstract: Chemicals have improved our quality of life, but the resulting environmental pollution has the potential to cause detrimental effects on humans and the environment. People and biota are chronically exposed to thousands of chemicals from various environmental sources through multiple pathways. Environmental chemists and toxicologists have moved beyond detecting and quantifying single chemicals to characterizing complex mixtures of chemicals in indoor and outdoor environments and biological matrices. We highlight analytical and bioanalytical approaches to isolating, characterizing, and tracking groups of chemicals of concern in complex matrices. Techniques that combine chemical analysis and bioassays have the potential to facilitate the identification of mixtures of chemicals that pose a combined risk.
305 citations
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University of Toronto1, University Health Network2, Braunschweig University of Technology3, University of Luxembourg4, Australian National University5, Tokyo Medical and Dental University6, Yale University7, University of Marburg8, University of Southern Denmark9, University of Düsseldorf10, Harvard University11
TL;DR: It is reported that GSH is essential for T cell effector functions through its regulation of metabolic activity and plays an unexpected role in metabolic integration and reprogramming during inflammatory T cell responses.
305 citations
Authors
Showing all 4893 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jun Wang | 166 | 1093 | 141621 |
Leroy Hood | 158 | 853 | 128452 |
Andreas Heinz | 108 | 1078 | 45002 |
Philippe Dubois | 101 | 1098 | 48086 |
John W. Berry | 97 | 351 | 52470 |
Michael Müller | 91 | 333 | 26237 |
Bart Preneel | 82 | 844 | 25572 |
Bjorn Ottersten | 81 | 1058 | 28359 |
Sander Kersten | 79 | 246 | 23985 |
Alexandre Tkatchenko | 77 | 271 | 26863 |
Rudi Balling | 75 | 238 | 19529 |
Lionel C. Briand | 75 | 380 | 24519 |
Min Wang | 72 | 716 | 19197 |
Stephen H. Friend | 70 | 184 | 53422 |
Ekhard K. H. Salje | 70 | 581 | 19938 |