University of Luxembourg

About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Population & European union. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.

Cognitive Radio Techniques Under Practical Imperfections: A Survey

Abstract: Cognitive radio (CR) has been considered as a potential candidate for addressing the spectrum scarcity problem of future wireless networks. Since its conception, several researchers, academic institutions, industries, and regulatory and standardization bodies have put their significant efforts toward the realization of CR technology. However, as this technology adapts its transmission based on the surrounding radio environment, several practical issues may need to be considered. In practice, several imperfections, such as noise uncertainty, channel/interference uncertainty, transceiver hardware imperfections, signal uncertainty, and synchronization issues, may severely deteriorate the performance of a CR system. To this end, the investigation of realistic solutions toward combating various practical imperfections is very important for the successful implementation of cognitive technology. In this direction, first, this survey paper provides an overview of the enabling techniques for CR communications. Subsequently, it discusses the main imperfections that may occur in the most widely used CR paradigms and then reviews the existing approaches toward addressing these imperfections. Finally, it provides some interesting open research issues.

Energy-efficient data replication in cloud computing datacenters

Abstract: Cloud computing is an emerging paradigm that provides computing, communication and storage resources as a service over a network. Communication resources often become a bottleneck in service provisioning for many cloud applications. Therefore, data replication which brings data (e.g., databases) closer to data consumers (e.g., cloud applications) is seen as a promising solution. It allows minimizing network delays and bandwidth usage. In this paper we study data replication in cloud computing data centers. Unlike other approaches available in the literature, we consider both energy efficiency and bandwidth consumption of the system. This is in addition to the improved quality of service QoS obtained as a result of the reduced communication delays. The evaluation results, obtained from both mathematical model and extensive simulations, help to unveil performance and energy efficiency tradeoffs as well as guide the design of future data replication solutions.

Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma

Abstract: Small noncoding microRNAs (miRNA) regulate the expression of target mRNAs by repressing their translation or orchestrating their sequence-specific degradation. In this study, we investigated miRNA and miRNA target gene expression patterns in melanoma to identify candidate biomarkers for early and progressive disease. Because data presently available on miRNA expression in melanoma are inconsistent thus far, we applied several different miRNA detection and profiling techniques on a panel of 10 cell lines and 20 patient samples representing nevi and primary or metastatic melanoma. Expression of selected miRNAs was inconsistent when comparing cell line-derived and patient-derived data. Moreover, as expected, some discrepancies were also detected when miRNA microarray data were correlated with qPCR-measured expression levels. Nevertheless, we identified miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples. In contrast, miR-146a and miR-155 were upregulated in all analyzed patients but none of the cell lines. Whole-genome microarrays were performed for analysis of selected melanoma cell lines to identify potential transcriptionally regulated miRNA target genes. Using Ingenuity pathway analysis, we identified a deregulated gene network centered around microphthalmia-associated transcription factor, a transcription factor known to play a key role in melanoma development. Our findings define miRNAs and miRNA target genes that offer candidate biomarkers in human melanoma.