Institution
University of Luxembourg
Education•Luxembourg, Luxembourg•
About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Population & European union. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors discussed the defect responsible for Shockley-Read-Hall recombination, and concluded that the recombination is not likely the source of the open circuit voltage loss, however, inhomogeneities of the band gap can be excluded because they are too small to have significant influence.
190 citations
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University of Cambridge1, Hertfordshire Partnership University NHS Foundation Trust2, University of Hertfordshire3, Eötvös Loránd University4, University of Cape Town5, Yale University6, University of Zurich7, University of Duisburg-Essen8, Erwin L. Hahn Institute for Magnetic Resonance Imaging9, University of Luxembourg10, University Hospital of Lausanne11, Tel Aviv University12, University of Adelaide13, University of Chicago14, Monash University15, University of Milan16, Stanford University17, University of Lübeck18, Albert Einstein College of Medicine19, University of Amsterdam20, Bellvitge University Hospital21, Sheba Medical Center22, Lithuanian University of Health Sciences23, McMaster University24, University of Florence25
TL;DR: Nine critical and achievable research priorities identified by the Network, needed in order to advance understanding of PUI, with a view towards identifying vulnerable individuals for early intervention are described.
190 citations
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TL;DR: It is demonstrated that SVA elements are mobilized in HeLa cells only in the presence of both L1-encoded proteins, ORF1p and ORF2p, and SVA trans-mobilization rates exceeded pseudogene formation frequencies by 12- to 300-fold in He La-HA cells, indicating that S VA elements represent a preferred substrate for L1 proteins.
Abstract: SINE-VNTR-Alu (SVA) elements are non-autonomous, hominid-specific non-LTR retrotransposons and distinguished by their organization as composite mobile elements. They represent the evolutionarily youngest, currently active family of human non-LTR retrotransposons, and sporadically generate disease-causing insertions. Since preexisting, genomic SVA sequences are characterized by structural hallmarks of Long Interspersed Elements 1 (LINE-1, L1)-mediated retrotransposition, it has been hypothesized for several years that SVA elements are mobilized by the L1 protein machinery in trans. To test this hypothesis, we developed an SVA retrotransposition reporter assay in cell culture using three different human-specific SVA reporter elements. We demonstrate that SVA elements are mobilized in HeLa cells only in the presence of both L1-encoded proteins, ORF1p and ORF2p. SVA trans-mobilization rates exceeded pseudogene formation frequencies by 12- to 300-fold in HeLa-HA cells, indicating that SVA elements represent a preferred substrate for L1 proteins. Acquisition of an AluSp element increased the trans-mobilization frequency of the SVA reporter element by ~25-fold. Deletion of (CCCTCT)(n) repeats and Alu-like region of a canonical SVA reporter element caused significant attenuation of the SVA trans-mobilization rate. SVA de novo insertions were predominantly full-length, occurred preferentially in G+C-rich regions, and displayed all features of L1-mediated retrotransposition which are also observed in preexisting genomic SVA insertions.
189 citations
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TL;DR: It is demonstrated that three-dimensional differentiation of expandable midbrain floor plate neural progenitor cells (mfNPCs) leads to organoids that resemble key features of the human midbrain that investigate PD-relevant patho-mechanisms.
Abstract: Modeling Parkinson’s disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored aspects of this neurodegenerative disorder. Here, we demonstrate that three-dimensional (3D) differentiation of expandable midbrain floor plate neural progenitor cells (mfNPCs) leads to organoids that resemble key features of the human midbrain. These organoids are composed of midbrain dopaminergic neurons (mDANs), which produce and secrete dopamine. Midbrain-specific organoids derived from PD patients carrying the LRRK2-G2019S mutation recapitulate disease-relevant phenotypes. Automated high-content image analysis shows a decrease in the number and complexity of mDANs in LRRK2-G2019S compared to control organoids. The floor plate marker FOXA2, required for mDAN generation, increases in PD patient-derived midbrain organoids, suggesting a neurodevelopmental defect in mDANs expressing LRRK2-G2019S. Thus, we provide a robust method to reproducibly generate 3D human midbrain organoids containing mDANs to investigate PD-relevant patho-mechanisms.
189 citations
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10 Sep 2012TL;DR: This paper proposes a new secure outsourcing algorithm for (variable-exponent, variable-base) exponentiation modulo a prime in the two untrusted program model and proposes the first efficient outsource-secure algorithm for simultaneous modular exponentiations.
Abstract: Modular exponentiations have been considered the most expensive operation in discrete-logarithm based cryptographic protocols. In this paper, we propose a new secure outsourcing algorithm for exponentiation modular a prime in the one-malicious model. Compared with the state-of-the-art algorithm [33], the proposed algorithm is superior in both efficiency and checkability. We then utilize this algorithm as a subroutine to achieve outsource-secure Cramer-Shoup encryptions and Schnorr signatures. Besides, we propose the first outsource-secure and efficient algorithm for simultaneous modular exponentiations. Moreover, we prove that both the algorithms can achieve the desired security notions.
189 citations
Authors
Showing all 4893 results
Name | H-index | Papers | Citations |
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Jun Wang | 166 | 1093 | 141621 |
Leroy Hood | 158 | 853 | 128452 |
Andreas Heinz | 108 | 1078 | 45002 |
Philippe Dubois | 101 | 1098 | 48086 |
John W. Berry | 97 | 351 | 52470 |
Michael Müller | 91 | 333 | 26237 |
Bart Preneel | 82 | 844 | 25572 |
Bjorn Ottersten | 81 | 1058 | 28359 |
Sander Kersten | 79 | 246 | 23985 |
Alexandre Tkatchenko | 77 | 271 | 26863 |
Rudi Balling | 75 | 238 | 19529 |
Lionel C. Briand | 75 | 380 | 24519 |
Min Wang | 72 | 716 | 19197 |
Stephen H. Friend | 70 | 184 | 53422 |
Ekhard K. H. Salje | 70 | 581 | 19938 |