University of Luxembourg

About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Population & European union. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

Abstract: Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells.

A Likelihood-Based Analysis for Relaxing the Exclusion Restriction in Randomized Experiments with Imperfect Compliance

Abstract: This paper examines the problem of relaxing the exclusion restriction for the evaluation of causal effects in randomized experiments with imperfect compliance. Exclusion restriction is a relevant assumption for identifying causal effects by the nonparametric instrumental variables technique, in which the template of a randomized experiment with imperfect compliance represents a natural parametric extension. However, the full relaxation of the exclusion restriction yields likelihood functions characterized by the presence of mixtures of distributions. This complicates a likelihood-based analysis because it implies partially identified models and more than one maximum likelihood point. We consider the model identifiability when the outcome distributions of various compliance states are in the same parametric class. A two-step estimation procedure based on detecting the root closest to the method of moments estimate of the parameter vector is proposed and analyzed in detail under normally distributed outcomes. An economic example with real data on return to schooling concludes the paper.

Fresh re-keying: security against side-channel and fault attacks for low-cost devices

Abstract: The market for RFID technology has grown rapidly over the past few years. Going along with the proliferation of RFID technology is an increasing demand for secure and privacy-preserving applications. In this context, RFID tags need to be protected against physical attacks such as Differential Power Analysis (DPA) and fault attacks. The main obstacles towards secure RFID are the extreme constraints of passive tags in terms of power consumption and silicon area, which makes the integration of countermeasures against physical attacks even more difficult than for other types of embedded systems. In this paper we propose a fresh re-keying scheme that is especially suited for challenge-response protocols such as used to authenticate tags. We evaluate the resistance of our scheme against fault and side-channel analysis, and introduce a simple architecture for VLSI implementation. In addition, we estimate the cost of our scheme in terms of area and execution time for various security/performance trade-offs. Our experimental results show that the proposed re-keying scheme provides better security (and does so at less cost) than state-of-the-art countermeasures.

Raman spectroscopy of rare-earth orthoferrites R FeO 3 ( R =La, Sm, Eu, Gd, Tb, Dy)

Abstract: We report a Raman scattering study of six rare-earth orthoferrites $R{\mathrm{FeO}}_{3}$, with $R$ = La, Sm, Eu, Gd, Tb, Dy. The use of extensive polarized Raman scattering of ${\mathrm{SmFeO}}_{3}$ and first-principles calculations enable the assignment of the observed phonon modes to vibrational symmetries and atomic displacements. The assignment of the spectra and their comparison throughout the whole series allow correlating the phonon modes with the orthorhombic structural distortions of $R{\mathrm{FeO}}_{3}$ perovskites. In particular, the positions of two specific $A{}_{g}$ modes scale linearly with the two ${\mathrm{FeO}}_{6}$ octahedra tilt angles, allowing the distortion to be tracked throughout the series. At variance with literature, we find that the two octahedra tilt angles scale differently with the vibration frequencies of their respective $A{}_{g}$ modes. This behavior, as well as the general relations between the tilt angles, the frequencies of the associated modes, and the ionic radii are rationalized in a simple Landau model. The reported Raman spectra and associated phonon-mode assignment provide reference data for structural investigations of the whole series of orthoferrites.