Institution
University of Macau
Education•Macao, Macau, China•
About: University of Macau is a education organization based out in Macao, Macau, China. It is known for research contribution in the topics: Population & Control theory. The organization has 6636 authors who have published 18324 publications receiving 327384 citations. The organization is also known as: UM & UMAC.
Papers published on a yearly basis
Papers
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TL;DR: A novel prediction-integration strategy optimization (PISO) model is proposed, which learns the interaction relationship between prosumer bidding actions and market responses from historical transaction data, and can be conveniently transformed and integrated into the prosumer operation optimization model in the form of constraints.
134 citations
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TL;DR: An international perspective on prevention strategies for Internet gaming disorder and related health conditions (e.g., Internet addiction) as well as hazardous gaming and Internet use is presented, followed by a systematic review of quantitative research evidence.
Abstract: Problems related to high levels of gaming and Internet usage are increasingly recognized as a potential public health burden across the developed world. The aim of this review was to present an international perspective on prevention strategies for Internet gaming disorder and related health conditions (e.g., Internet addiction), as well as hazardous gaming and Internet use. A systematic review of quantitative research evidence was conducted, followed by a search of governmental reports, policy and position statements, and health guidelines in the last decade. The regional scope included the USA, UK, Australia, China, Germany, Japan, and South Korea. Prevention studies have mainly involved school-based programs to train healthier Internet use habits in adolescents. The efficacy of selective prevention is promising but warrants further empirical attention. On an international scale, the formal recognition of gaming or Internet use as a disorder or as having quantifiable harms at certain levels of usage has been foundational to developing structured prevention responses. The South Korean model, in particular, is an exemplar of a coordinated response to a public health threat, with extensive government initiatives and long-term strategic plans at all three levels of prevention (i.e., universal, selective, and indicated). Western regions, by comparison, are dominated by prevention approaches led by non-profit organizations and private enterprise. The future of prevention of gaming and Internet problems ultimately relies upon all stakeholders working collaboratively in the public interest, confronting the reality of the evidence base and developing practical, ethical, and sustainable countermeasures.
134 citations
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TL;DR: The maximum-entropy-regularized weighted fuzzy c-means (EWFCM) algorithm is proposed and a new objective function is developed in the proposed algorithm to achieve the optimal clustering result by minimizing the dispersion within clusters and maximizing the entropy of attribute weights simultaneously.
134 citations
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TL;DR: The strategies for quantification, related to the markers, reference compounds and approaches, in quality control of CM were reviewed and discussed and the valid method for quantitatively evaluating the quality of CM is poor.
133 citations
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TL;DR: Curcumin derivative C1 is identified as a novel MTOR-independent activator of TFEB, which enhances autophagy and lysosome biogenesis in vitro and in vivo and is a potential therapeutic agent for the treatment of neurodegenerative diseases.
Abstract: Autophagy dysfunction is a common feature in neurodegenerative disorders characterized by accumulation of toxic protein aggregates. Increasing evidence has demonstrated that activation of TFEB (transcription factor EB), a master regulator of autophagy and lysosomal biogenesis, can ameliorate neurotoxicity and rescue neurodegeneration in animal models. Currently known TFEB activators are mainly inhibitors of MTOR (mechanistic target of rapamycin [serine/threonine kinase]), which, as a master regulator of cell growth and metabolism, is involved in a wide range of biological functions. Thus, the identification of TFEB modulators acting without inhibiting the MTOR pathway would be preferred and probably less deleterious to cells. In this study, a synthesized curcumin derivative termed C1 is identified as a novel MTOR-independent activator of TFEB. Compound C1 specifically binds to TFEB at the N terminus and promotes TFEB nuclear translocation without inhibiting MTOR activity. By activating TFEB, C1 enhances autophagy and lysosome biogenesis in vitro and in vivo. Collectively, compound C1 is an orally effective activator of TFEB and is a potential therapeutic agent for the treatment of neurodegenerative diseases.
133 citations
Authors
Showing all 6766 results
Name | H-index | Papers | Citations |
---|---|---|---|
Henry T. Lynch | 133 | 925 | 86270 |
Chu-Xia Deng | 125 | 444 | 57000 |
H. Vincent Poor | 109 | 2116 | 67723 |
Peng Chen | 103 | 918 | 43415 |
George F. Gao | 102 | 793 | 82219 |
MengChu Zhou | 96 | 1124 | 36969 |
Gang Li | 93 | 486 | 68181 |
Rob Law | 81 | 714 | 31002 |
Zongjin Li | 80 | 630 | 22103 |
Han-Ming Shen | 80 | 237 | 27410 |
Heng Li | 79 | 745 | 23385 |
Lionel M. Ni | 75 | 466 | 28770 |
C. L. Philip Chen | 74 | 482 | 20223 |
Chun-Su Yuan | 72 | 397 | 21089 |
Joao P. Hespanha | 72 | 418 | 39004 |