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Institution

University of Macau

EducationMacao, Macau, China
About: University of Macau is a education organization based out in Macao, Macau, China. It is known for research contribution in the topics: Population & Control theory. The organization has 6636 authors who have published 18324 publications receiving 327384 citations. The organization is also known as: UM & UMAC.


Papers
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Journal ArticleDOI
Abstract: The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2), has impacted human lives in the most profound ways with millions of infections and deaths. Scientists and pharmaceutical companies have been in race to produce vaccines against SARS-CoV-2. Vaccine generation usually demands years of developing and testing for efficacy and safety. However, it only took less than one year to generate two mRNA vaccines from their development to deployment. The rapid production time, cost-effectiveness, versatility in vaccine design, and clinically proven ability to induce cellular and humoral immune response have crowned mRNA vaccines with spotlights as most promising vaccine candidates in the fight against the pandemic. In this review, we discuss the general principles of mRNA vaccine design and working mechanisms of the vaccines, and provide an up-to-date summary of pre-clinical and clinical trials on seven anti-COVID-19 mRNA candidate vaccines, with the focus on the two mRNA vaccines already licensed for vaccination. In addition, we highlight the key strategies in designing mRNA vaccines to maximize the expression of immunogens and avoid intrinsic innate immune response. We also provide some perspective for future vaccine development against COVID-19 and other pathogens.

142 citations

Journal ArticleDOI
TL;DR: Findings support the consumption of edible flowers as functional foods and their use as sources of natural antioxidants by the food industry.
Abstract: Edible flowers are receiving renewed interest as rich sources of bioactive compounds. Ethanol extracts of eight edible flowers were phytochemically characterized and investigated for their bioactivity. Rutin, quercetin, luteolin, kaempferol, and myricetin were selected as standards and quantified by HPLC. The fatty acid profile was analyzed by GC and GC-MS. Antioxidant properties were evaluated by using different in vitro tests. The hypoglycemic effects were investigated via the inhibition of α-amylase and α-glucosidase. Sambucus nigra exhibited the highest radical-scavenging activity (IC50 of 1.4 μg/mL), followed by Hedysarum coronarium (IC50 of 1.6 μg/mL). Both species contained high quercetin and rutin contents. S. nigra extract exerted the highest activity in preventing lipid oxidation. Malva sylvestris extract inhibited both α-amylase and α-glucosidase with IC50 values of 7.8 and 11.3 μg/mL, respectively. These findings support the consumption of edible flowers as functional foods and their use as sources of natural antioxidants by the food industry.

141 citations

Journal ArticleDOI
TL;DR: The presented delineator characterizes arterial blood pressure waveforms in a beat-by-beat manner, and firstly seeks the pairs of inflection and zero-crossing points, and then utilizes combinatorial amplitude and interval criteria to select the onset and systolic peak.

141 citations

Journal ArticleDOI
TL;DR: Simulations illustrate the effectiveness of the proposed bounded controller for tracking a moving target, which is designed based on the neural estimation model and a saturated function and bounded with the bounds known as a priori.
Abstract: This paper is concerned with the target tracking of underactuated autonomous surface vehicles with unknown dynamics and limited control torques. The velocity of the target is unknown, and only the measurements of line-of-sight range and angle are obtained. First, a kinematic control law is designed based on an extended state observer, which is utilized to estimate the uncertain target dynamics due to the unknown velocities. Next, an estimation model based on a single-hidden-layer neural network is developed to approximate the unknown follower dynamics induced by uncertain model parameters, unmodeled dynamics, and environmental disturbances. A bounded control law is designed based on the neural estimation model and a saturated function. The salient feature of the proposed controller is twofold. First, only the measured line-of-sight range and angle are used, and the velocity information of the target is not required. Second, the control torques are bounded with the bounds known as a priori . The input-to-state stability of the closed-loop system is analyzed via cascade theory. Simulations illustrate the effectiveness of the proposed bounded controller for tracking a moving target.

141 citations

Journal ArticleDOI
TL;DR: The 'cargo-ligand-receptor' model in selective autophagy for specific organelles or cellular components in yeast and mammals is emphasized, with a focus on mitophagy and ER-phagy, which are finely described as types of selective autophile.
Abstract: Macroautophagy (hereafter called autophagy) is a highly conserved physiological process that degrades over-abundant or damaged organelles, large protein aggregates and invading pathogens via the lysosomal system (the vacuole in plants and yeast). Autophagy is generally induced by stress, such as oxygen-, energy- or amino acid-deprivation, irradiation, drugs, etc. In addition to non-selective bulk degradation, autophagy also occurs in a selective manner, recycling specific organelles, such as mitochondria, peroxisomes, ribosomes, endoplasmic reticulum (ER), lysosomes, nuclei, proteasomes and lipid droplets (LDs). This capability makes selective autophagy a major process in maintaining cellular homeostasis. The dysfunction of selective autophagy is implicated in neurodegenerative diseases (NDDs), tumorigenesis, metabolic disorders, heart failure, etc. Considering the importance of selective autophagy in cell biology, we systemically review the recent advances in our understanding of this process and its regulatory mechanisms. We emphasize the 'cargo-ligand-receptor' model in selective autophagy for specific organelles or cellular components in yeast and mammals, with a focus on mitophagy and ER-phagy, which are finely described as types of selective autophagy. Additionally, we highlight unanswered questions in the field, helping readers focus on the research blind spots that need to be broken.

141 citations


Authors

Showing all 6766 results

NameH-indexPapersCitations
Henry T. Lynch13392586270
Chu-Xia Deng12544457000
H. Vincent Poor109211667723
Peng Chen10391843415
George F. Gao10279382219
MengChu Zhou96112436969
Gang Li9348668181
Rob Law8171431002
Zongjin Li8063022103
Han-Ming Shen8023727410
Heng Li7974523385
Lionel M. Ni7546628770
C. L. Philip Chen7448220223
Chun-Su Yuan7239721089
Joao P. Hespanha7241839004
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202345
2022307
20212,579
20202,357
20192,075
20181,714