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Institution

University of Madras

EducationChennai, Tamil Nadu, India
About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.


Papers
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Journal ArticleDOI
TL;DR: In diabetic rat pancreas, both GS3 and GS4 were able to double the islet number and beta cell number, and this herbal therapy appears to bring about blood glucose homeostasis through increased serum insulin levels provided by repair/regeneration of the endocrine Pancreas.

312 citations

Journal ArticleDOI
TL;DR: Various mechanisms of Akt dysregulation in cancers are discussed, including epigenetic modifications like methylation, post-transcriptional non-coding RNAs-mediated regulation, and the overexpression and mutation.

307 citations

Journal ArticleDOI
TL;DR: The results suggest that the antioxidant deficiency and excessive peroxide-mediated damage may appear early on in non-insulin-dependent diabetes mellitus, before the development of secondary complications.
Abstract: 1. This study was conducted on 467 cases of non-insulin-dependent diabetes mellitus and 180 healthy controls. Lipid peroxidation products in plasma and erythrocytes were assayed as thiobarbituric acid reactive substances, along with the erythrocyte antioxidant enzymes, namely superoxide dismutase, catalase and glutathione peroxidase. In addition, scavenger vitamins A, C and E and reduced glutathione levels in blood were also measured. 2. Lipid peroxidation was significantly raised within the first 2 years of diagnosis, and superoxide dismutase, catalase, reduced glutathione and vitamins C and E were significantly lowered. 3. These changes were correlated with the duration of the disease and were of a higher magnitude with the development of complications. 4. The results suggest that the antioxidant deficiency and excessive peroxide-mediated damage may appear early on in non-insulin-dependent diabetes mellitus, before the development of secondary complications.

307 citations

Journal ArticleDOI
TL;DR: OVX induces oxidative stress in the femur bone of rats and enzymatic antioxidants like SOD, GPx, GST were decreased in ovariectomized animals when compared to sham-operated control rats.

307 citations

Journal ArticleDOI
TL;DR: In a preliminary study, carriers of hepatitis B virus were treated with a preparation of the plant Phyllanthus amarus for 30 days and 22 of 37 treated patients had lost hepatitis B surface antigen when tested 15-20 days after the end of the treatment.

293 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
202283
2021644
2020564
2019457
2018435