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Institution

University of Madras

EducationChennai, Tamil Nadu, India
About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.


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Journal ArticleDOI
TL;DR: Lupeol, when supplemented at a dosage of 40 mg kg−1 body weight concurrent with cadmium administration, showed an improvement in the antioxidant status and the level of lipid peroxides showed a significant decrease, which shows the nephroprotective action of the drug.
Abstract: This study pertains to the role of lupeol, a pentacyclic triterpene, against the toxic manifestations of chronic cadmium exposure. Cadmium is a potent nephrotoxin on prolonged exposure. Cadmium (as cadmium chloride) at a dose of 1 mg kg−1 body weight was administered subcutaneously for 15 days to rats. This led to an increase in the level of lipid peroxides and a decrease in the level of antioxidants in the kidney. Lupeol, when supplemented at a dosage of 40 mg kg−1 body weight concurrent with cadmium administration, showed an improvement in the antioxidant status. The level of lipid peroxides also showed a significant decrease, which shows the nephroprotective action of the drug Copyright © 2000 John Wiley & Sons, Ltd.

75 citations

Journal ArticleDOI
TL;DR: Results suggested that TAM treatment is the most effective during co-administration of riboflavin, niacin and CoQ10 in terms of mitochondrial antioxidant and antitumour activity.

75 citations

Journal ArticleDOI
TL;DR: The present study indicates that the protective nature of Sargassum polycystum extract may be due to the presence of active compounds possessing antilipemic property against acetaminophen challenge.
Abstract: The effect of Sargassum polycystum crude extract on lipid metabolism was examined against acetaminophen-induced (800 mg/kg body wt., intraperitoneally) hyperlipidemia during toxic hepatitis in experimental rats. The animals intoxicated with acetaminophen showed significant elevation in the levels of cholesterol, triglycerides and free fatty acid in both serum and liver tissue. The levels of tissue total lipids and serum LDL-cholesterol were also elevated with depleted levels of serum HDL-cholesterol and tissue phospholipid. The acetaminophen-induced animals showed significant alterations in the activities of lipid metabolizing enzymes serum lecithin cholesterol acyl transferase (LCAT) and hepatic triglyceride lipase (HTGL). The levels of liver tissue fatty acids (saturated, mono and polyunsaturated) such as palmitic acid, stearic acid, oleic acid, linoleic acid, arachidonic acid and linolenic acid monitored by gas chromatography were considerably altered in acetaminophen intoxicated animals when compared with control animals. The prior oral administration of Sargassum polycystum (200 mg/kg body wt./day for a period of 15 days) crude extract showed considerable prevention in the severe disturbances of lipid profile and metabolizing enzymes triggered by acetaminophen during hepatic injury. Liver histology also showed convincing supportive evidence regarding their protective nature against fatty changes induced during acetaminophen intoxication. Thus the present study indicates that the protective nature of Sargassum polycystum extract may be due to the presence of active compounds possessing antilipemic property against acetaminophen challenge. (Mol Cell Biochem 276: 89–96, 2005)

75 citations

Journal ArticleDOI
TL;DR: The beneficial effect of EGCG in alleviating oxidative disturbances in ageing and retard the age associated derangements in both mitotic and post-mitotic tissues is supported.

75 citations

Journal ArticleDOI
TL;DR: The Ni nanoparticles with fcc or hcp phases have been synthesized in tetraethylene glycol by using the modified polyol process as discussed by the authors, and the crystal structure has been controlled by changing the polyol/Ni mole ratio and reaction temperature.
Abstract: The Ni nanoparticles with fcc or hcp phases have been synthesized in tetraethylene glycol by using the modified polyol process. The crystal structure has been controlled by changing the polyol/Ni mole ratio and the reaction temperature. The saturation magnetization of the as-prepared particles depends on the relative volume fraction of the hcp phase. The x-ray diffraction and extended x-ray absorption fine structure studies suggest the formation of pure fcc and hcp Ni phases. The hcp Ni particles show nonmagnetic behavior and thermally stable below 673K.

75 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
202283
2021644
2020564
2019457
2018435