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Institution

University of Madras

EducationChennai, Tamil Nadu, India
About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.


Papers
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Journal ArticleDOI
TL;DR: In vivo two-photon imaging of Zn2+ ions in hepatocytes of live rats illustrated the viability of the probe in tissue imaging and monitoring of free zinc ions in live cells.
Abstract: A bipyridine centered donor–acceptor–donor (D–π–A–π–D) type ratiometric fluorescent molecular probe exhibited an unprecedented enhancement in the two-photon absorption (2PA) cross section upon Zn2+ binding. Moreover, owing to the excited state charge-transfer of the fluorophore π-backbone, a significant enhancement in the two-photon (2P) excited fluorescence intensity was observed upon Zn2+ binding, resulting in a 13-fold enhancement in the 2PA cross section and a 9-fold enhancement in fluorescence brightness at 620 nm when compared to the cation-free fluorophore. The large 2PA cross section of 1433 GM and 2P action cross section (860 GM), with an excellent 2P excited fluorescence variation from 517 to 620 nm upon Zn2+ binding, facilitated the ratiometric monitoring of free zinc ions in cells. The low cytotoxicity and good photostability of the fluorophore allowed two-photon Zn2+ imaging of HeLa cells. In addition, in vivo two-photon imaging of Zn2+ ions in hepatocytes of live rats illustrated the viability of the probe in tissue imaging and monitoring of free zinc ions in live cells.

64 citations

Journal ArticleDOI
TL;DR: Lupeol, a pentacyclic triterpene was isolated from C. nurvala stem bark and its ester lupeol linoleate was synthesised and these triterpenes were tested for their anti-inflammatory activity in complete Freundas adjuvant induced arthritic rats.

64 citations

Journal ArticleDOI
TL;DR: The results indicate that using NZVI in combination with ultrasonication is an efficient method for the treatment of petroleum refinery wastewater.

64 citations

Journal ArticleDOI
TL;DR: It is suggested that eugenol, by incorporating into the membrane protects it from free radical attack, and by maintaining the activities of the antioxidant enzymes at normal levels removes the oxidative stress imposed by CCl 4.
Abstract: Simultaneous administration of eugenol (10.7 mg/kg of body weight/day) with carbon tetrachloride (CCl 4 ) (1.195 g/kg of body weight, i.p. 3 times a week for 2 weeks) to rats protected the loss of functional integrity and membrane lipid alterations in red blood cells (RBCs) induced by oxidative stress. Eugenol, an allyl benzene that is the major ingredient of cloves, Osimum, and nutmeg, inhibits the accumulation of lipid peroxidation products in red blood cells and maintains the activities of the antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase(s), glutathione reductase, and glucose-6-phosphate dehydrogenase at normal levels. The CCl 4 -induced increase in membrane fluidity was decreased by eugenol, and the altered activities of membrane-bound enzymes Na + , K + -ATPase, NADH-dehydrogenase, and Ca 2+ -ATPase were normalized. Eugenol exhibited a concentration-dependent binding into RBC membranes in vitro, and it also inhibited the hemolysis of RBCs induced by liver S9 fraction-treated CCl 4 . Hence, it is suggested that eugenol, by incorporating into the membrane protects it from free radical attack, and by maintaining the activities of the antioxidant enzymes at normal levels removes the oxidative stress imposed by CCl 4 .

64 citations

Journal ArticleDOI
TL;DR: Data support the hypothesis and show that chronic chromium exposure induces a reversible oxidative stress in the seminal plasma and sperm by creating an imbalance between reactive oxygen species and antioxidant system, leading to sperm death and reduced motility of live sperm.

64 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
202283
2021644
2020564
2019457
2018435