University of Madras

About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.

Antioxidant lipoate and tissue antioxidants in aged rats

Abstract: Oxidative metabolism produces free radicals that must be removed from the cellular environment for the cell to survive. The levels of nonenzymic antioxidants involved in the elimination of free radicals were investigated in an attempt to correlate any changes in the levels of enzymic antioxidants during aging with changes in free radical mediated cellular damage. Antioxidants were measured in liver and kidney of young and aged rats with respect to DL-α-lipoic acid supplemented rats. In both organs lipid peroxidation damage (a marker of free radical mediated damage) increased with age, and a significant decrease in antioxidant systems was observed. Moreover, DL-α-lipoic acid treated aged rats showed a decrease in the level of lipid peroxides and an increase in the antioxidant status. The results of this study provide evidence that DL-α-lipoic acid treatment can improve antioxidants during aging and minimize the age-associated disorders in which free radicals are the major cause.

Anti-nociceptive activity of hygrophila auriculata (schum) heine

Abstract: Hygrophila auriculata (Schum) Heine (syn) Asteracantha longifolia Nees, Acanthaceae was described in ayurvedic literature as Ikshura, Ikshugandha, and Kokilasha. The plant was extensively used in traditional system of medicine for various ailments like rheumatism, inflammation, jaundice, hepatic obstruction, pain, etc. The aqueous extract of aerial parts (HAA) and root(HAR) were screened for its anti-nociceptive property using both chemical and thermal methods of nociception in mice. In chemical method acetic acid writhing test and in thermal methods hot plate and tail flick tests were performed. Both the extracts at doses 100 and 200 mg/kg/p.o inhibited the abdominal constrictions induced by acetic acid and also increased the pain threshold of mice towards the thermal source in a dose dependent manner. The activity exhibited by the extracts was comparable to that of the standard drug aspirin (100 mg/kg/p.o). From the results it was concluded that both extracts exhibited anti-nociceptive activity by central and peripheral mechanism(s).