University of Madras

About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.

Kinetic studies on visible light-assisted degradation of acid red 88 in presence of metal-ion coupled oxone reagent

Abstract: Visible light-assisted photo-Fenton-like oxidation of a mono-azo textile dye, acid red 88 (AR88), has been carried out in presence of Cu2+ or Fe3+ ions as the catalyst and oxone as the oxidant. The optimal concentrations of metal-ion (Cu2+ or Fe3+) and oxidant (oxone) for the abatement of the azo dye were determined. Decolorization of AR88 in Cu2+/oxone system was found to follow zero-order kinetics with respect to the dye and first-order kinetics when Fe3+/oxone system was employed. In both the cases, the decolorization of AR88 was found to be accelerated with increasing concentrations of metal-ions in solution. Almost 95% decolorization was attained in 2 h with Cu2+ ion and within 14 min with Fe3+ at each metal-ion concentration of 0.075 mM. Mineralization studies were also carried out by monitoring the reduction of total organic carbon (TOC) content during the course of the reaction. A suitable mechanism has been proposed to explain the observed kinetics of decolorization of AR88 in both the Fe3+/oxone and Cu2+/oxone systems.

Effect of Triphala on oxidative stress and on cell-mediated immune response against noise stress in rats

Abstract: Stress is one of the basic factors in the etiology of number of diseases. The present study was aimed to investigate the effect of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) on noise-stress induced alterations in the antioxidant status and on the cell-mediated immune response in Wistar strain male albino rats. Noise-stress employed in this study was 100 dB for 4 h/d/15 days and Triphala was used at a dose of 1 g/kg/b.w/48 days. Eight different groups of rats namely, non-immunized: control, Triphala, noise-stress, Triphala with noise-stress, and corresponding immunized groups were used. Sheep red blood cells (5×109 cells/ml) were used to immunize the animals. Biochemical indicators of oxidative stress namely lipid peroxidation, antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), ascorbic acid in plasma and tissues (thymus and spleen) and SOD, GPx and corticosterone level in plasma were estimated. Cell-mediated immune response namely foot pad thickness (FPT) and leukocyte migration inhibition (LMI) test were performed only in immunized groups. Results showed that noise-stress significantly increased the lipid peroxidation and corticosterone level with concomitant depletion of antioxidants in plasma and tissues of both non-immunized and immunized rats. Noise-stress significantly suppressed the cell-mediated immune response by decreased FPT with an enhanced LMI test. The supplementation with Triphala prevents the noise-stress induced changes in the antioxidant as well as cell-mediated immune response in rats. This study concludes that Triphala restores the noise-stress induced changes may be due to its antioxidant properties.