Showing papers by "University of Malaya published in 2009"

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)

Abstract: The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various aspects of ACLF relevant to disease patterns and clinical practice in the Asia-Pacific region. Experts predominantly from the Asia–Pacific region constituted this working party and were requested to identify different issues of ACLF and develop the consensus guidelines. A 2-day meeting of the working party was held on January 22–23, 2008, at New Delhi, India, to discuss and finalize the consensus statements. Only those statements that were unanimously approved by the experts were accepted. These statements were circulated to all the experts and subsequently presented at the Annual Conference of the APASL at Seoul, Korea, in March 2008. The consensus statements along with relevant background information are presented in this review.

Mycophenolate Mofetil versus Cyclophosphamide for Induction Treatment of Lupus Nephritis

Abstract: Recent studies have suggested that mycophenolate mofetil (MMF) may offer advantages over intravenous cyclophosphamide (IVC) for the treatment of lupus nephritis, but these therapies have not been compared in an international randomized, controlled trial. Here, we report the comparison of MMF and IVC as induction treatment for active lupus nephritis in a multinational, two-phase (induction and maintenance) study. We randomly assigned 370 patients with classes III through V lupus nephritis to open-label MMF (target dosage 3 g/d) or IVC (0.5 to 1.0 g/m(2) in monthly pulses) in a 24-wk induction study. Both groups received prednisone, tapered from a maximum starting dosage of 60 mg/d. The primary end point was a prespecified decrease in urine protein/creatinine ratio and stabilization or improvement in serum creatinine. Secondary end points included complete renal remission, systemic disease activity and damage, and safety. Overall, we did not detect a significantly different response rate between the two groups: 104 (56.2%) of 185 patients responded to MMF compared with 98 (53.0%) of 185 to IVC. Secondary end points were also similar between treatment groups. There were nine deaths in the MMF group and five in the IVC group. We did not detect significant differences between the MMF and IVC groups with regard to rates of adverse events, serious adverse events, or infections. Although most patients in both treatment groups experienced clinical improvement, the study did not meet its primary objective of showing that MMF was superior to IVC as induction treatment for lupus nephritis.

Removal of Hexavalent Chromium-Contaminated Water and Wastewater: A Review

Abstract: Cr(VI) is a well-known highly toxic metal, considered a priority pollutant. Industrial sources of Cr(VI) include leather tanning, cooling tower blowdown, plating, electroplating, anodizing baths, rinse waters, etc. This article includes a survey of removal techniques for Cr(VI)-contaminated aqueous solutions. A particular focus is given to adsorption, membrane filtration, ion exchange, and electrochemical treatment methods. The primary objective of this article is to provide recent information about the most widely used techniques for Cr(VI) removal.

Norovirus Illness Is a Global Problem: Emergence and Spread of Norovirus GII.4 Variants, 2001–2007

Abstract: Background Noroviruses (NoVs) are the most common cause of viral gastroenteritis Their high incidence and importance in health care facilities result in a great impact on public health Studies from around the world describing increasing prevalence have been difficult to compare because of differing nomenclatures for variants of the dominant genotype, GII4 We studied the global patterns of GII4 epidemiology in relation to its genetic diversity Methods Data from NoV outbreaks with dates of onset from January 2001 through March 2007 were collected from 15 institutions on 5 continents Partial genome sequences (n = 775) were collected, allowing phylogenetic comparison of data from different countries Results The 15 institutions reported 3098 GII4 outbreaks, 62% of all reported NoV outbreaks Eight GII4 variants were identified Four had a global distribution-the 1996, 2002, 2004, and 2006b variants The 2003Asia and 2006a variants caused epidemics, but they were geographically limited Finally, the 2001 Japan and 2001Henry variants were found across the world but at low frequencies Conclusions NoV epidemics resulted from the global spread of GII4 strains that evolved under the influence of population immunity Lineages show notable (and currently unexplained) differences in geographic prevalence Establishing a global NoV network by which data on strains with the potential to cause pandemics can be rapidly exchanged may lead to improved prevention and intervention strategies

Multilevel Inverter For Grid-Connected PV System Employing Digital PI Controller

Abstract: This paper presents a single-phase five-level photovoltaic (PV) inverter topology for grid-connected PV systems with a novel pulsewidth-modulated (PWM) control scheme. Two reference signals identical to each other with an offset equivalent to the amplitude of the triangular carrier signal were used to generate PWM signals for the switches. A digital proportional-integral current control algorithm is implemented in DSP TMS320F2812 to keep the current injected into the grid sinusoidal and to have high dynamic performance with rapidly changing atmospheric conditions. The inverter offers much less total harmonic distortion and can operate at near-unity power factor. The proposed system is verified through simulation and is implemented in a prototype, and the experimental results are compared with that with the conventional single-phase three-level grid-connected PWM inverter.

Second Asia-Pacific Consensus Guidelines for Helicobacter Pylori Infection

Abstract: The Asia-Pacific Consensus Conference was convened to review and synthesize the most current information on Helicobacter pylori management so as to update the previously published regional guidelines. The group recognized that in addition to long-established indications, such as peptic ulcer disease, early mucosa-associated lymphoid tissue (MALT) type lymphoma and family history of gastric cancer, H. pylori eradication was also indicated for H. pylori infected patients with functional dyspepsia, in those receiving long-term maintenance proton pump inhibitor (PPI) for gastroesophageal reflux disease, and in cases of unexplained iron deficiency anemia or idiopathic thrombocytopenic purpura. In addition, a population 'test and treat' strategy for H. pylori infection in communities with high incidence of gastric cancer was considered to be an effective strategy for gastric cancer prevention. It was recommended that H. pylori infection should be tested for and eradicated prior to long-term aspirin or non-steroidal anti-inflammatory drug therapy in patients at high risk for ulcers and ulcer-related complications. In Asia, the currently recommended first-line therapy for H. pylori infection is PPI-based triple therapy with amoxicillin/metronidazole and clarithromycin for 7 days, while bismuth-based quadruple therapy is an effective alternative. There appears to be an increasing rate of resistance to clarithromycin and metronidazole in parts of Asia, leading to reduced efficacy of PPI-based triple therapy. There are insufficient data to recommend sequential therapy as an alternative first-line therapy in Asia. Salvage therapies that can be used include: (i) standard triple therapy that has not been previously used; (ii) bismuth-based quadruple therapy; (iii) levofloxacin-based triple therapy; and (iv) rifabutin-based triple therapy. Both CYP2C19 genetic polymorphisms and cigarette smoking can influence future H. pylori eradication rates.

Mapping human genetic diversity in Asia

Abstract: Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

The moderating effects of organizational culture on the relationships between leadership behaviour and organizational commitment and between organizational commitment and job satisfaction and performance

Abstract: Purpose – The purpose of this paper is to investigate the moderating effects of organizational culture on the relationships between leadership behaviour and organizational commitment and between organizational commitment and job satisfaction and performance in the Malaysian setting.Design/methodology/approach – Data were gathered from 238 Malaysian UM MBA part‐time students and the researchers' working peers. Data on the respondents' organizational culture and leadership behaviours, and how they affect organizational commitment, job satisfaction and employee performance, were collected using the OCI, leadership behaviour questionnaire, ACS, single global rating for job satisfaction and overall performance questionnaire, respectively. Descriptive statistics were reported, followed by factor analysis, reliability analysis, Pearson correlation and hypotheses testing using hierarchical multiple regression.Findings – Generally, and with a few exceptions, leadership behaviour was found to be significantly relat...

Expression Profile of MicroRNAs in Young Stroke Patients

Abstract: Background The methods currently available for diagnosis and prognosis of cerebral ischaemia still require further improvements. Micro-RNAs (small non-coding RNAs) have been recently reported as useful biomarkers in diseases such as cancer and diabetes. We therefore carried out microRNA (miRNA) profiling from peripheral blood to detect and identify characteristic patterns in ischaemic stroke. Methods/Principal Findings The ischaemic stroke patients aged between 18–49 years, characterized based on World Health Organization clinical criteria were further classified according to TOAST classification, a) Large-vessel atherosclerosis [n = 8] b) Small-vessel disease [n = 3] c) Cardioembolism [n = 5] d) Undetermined cause [n = 3]. The patients' functional status at the time of blood sampling (at the outpatient clinics) was evaluated with the modified Rankin Scale (mRS). Blood samples from normal (n = 5) individuals were used as controls. Total RNA extracted from whole blood was subjected to miroRNA profiling and real-time PCR analysis. miRNAs that are implicated in the endothelial/vascular function, erythropoiesis, angiogenesis and neural function showed differential expression profile as compared to the normal control. Interestingly, miRNAs that are involved in hypoxic conditions have also been found in our miRNA profiles. Conclusion We demonstrate that the peripheral blood miRNAs and their profiles can be developed as biomarkers in diagnosis and prognosis of cerebral ischaemic stroke. The dysregulated miRNAs have been detectable even after several months from the onset of stroke in what is usually regarded as neurologically stable patients.

Islamic tourism and managing tourism development in Islamic societies: the cases of Iran and Saudi Arabia

Abstract: This paper is concerned with the effects of state religion on tourism development in Muslim countries with particular reference to Iran and Saudi Arabia. Aspects of the relationship between Islam and tourism are investigated overall and issues of tourism policies, management and marketing and community involvement within the context of the two cases are discussed. The distinctive circumstances prevailing in Iran and Saudi Arabia are suggested, but more general insights are also presented into the interactions between and management of tourism and Islam. Copyright © 2009 John Wiley & Sons, Ltd.

Virtual Teams: a Literature Review

Abstract: In the competitive market , virtual teams represent a growing response to the need for fasting time-to- market, low-cost and rapid solutions to complex organizational problems. Virtual teams enable organizations to pool the talents and expertise of employees and non-employees by eliminating time and space barriers . Nowadays, companies are heavily investing in virtual team to enhance their performance and competitiveness. Despite virtual teams growing prevalence, relatively little is known about this new form of team. Hence the study offers an extensive literature review with definitions o f virtual teams and a structured analysis of the present body of knowledge of virtual teams. First, we distinguish virtual teams from conventional teams , different types of virtual teams to identify where current knowledge applies. Second, we distinguish what is needed for effective virtual team considering the people, process and technology point of view and underlying characteristics of virtual teams and challenges they entail. Finally, we have identified an d extended 12 key factors that need to be considered, and describes a methodology focused on supporting virtual team working, with a new approach that has not been specifically addressed in the existing literature and some guide line for future research extracted.

Evolution of solid waste management in Malaysia: impacts and implications of the solid waste bill, 2007

Abstract: Solid waste generation and its implications for people and the environment are global issues. The complexity of the waste composition and the ever-increasing percapita waste generation is a challenge for waste managers, particularly in developing countries. Thus, the need to have a clear policy on waste management and legislation to realize that policy is imperative. Malaysia is developing rapidly and problems such as the waste generation associated with development and industrialization are evident. The Solid Waste and Public Cleansing Management Bill, which was approved in August 2007 after a 10-year delay, is envisaged to have serious consequences in waste management practices and implementation in Malaysia. This article explores the main features of this all-encompassing bill and its impacts on the waste management scenario in Malaysia. In addition, a comparative evaluation is also discussed to explore the policies/legislation of selected countries vis-avis the Malaysian bill.

Successful enterprise resource planning implementation: taxonomy of critical factors

Abstract: – The purpose of this paper is to investigate the current literature base of critical success factors (CSFs) of enterprise resource planning (ERP) implementations, provide a systematic compilation of CSFs, and present a new comprehensive taxonomy of CSFs for ERP system implementation., – This paper compiles literature that highlighted possible references to CSFs for ERP implementation projects. Given that the purpose of this paper is to achieve a depth of understanding of the various CSFs already identified by other researchers, “content analysis” is used. Four stages of content analysis are adopted to collect and analyse the literature, i.e. data collection, open coding, axial coding, and selective coding., – By analyzing all CFSs mentioned in literature during the last ten years (1999‐2008), taxonomy of ERP CSFs implementation was formulated. In total 17 CSFs were identified, which is then categorized into five main categories., – Literature is collected from selected databases and journals from 1999 to 2008., – This paper is significant because taxonomy helps us organize the knowledge. Taxonomy can help the researchers to make their search easier by assigning CSFs to a category and defining relationships between those categories., – The output of this paper will help future researchers to increase identification of related studies in the literature review phase of their work.

Soft Skills at the Malaysian Institutes of Higher Learning.

Abstract: This article discusses human capital development through the seven soft skills elements which comprise communication skills, critical thinking and problem solving skills, team work, lifelong learning and information management skills, entrepreneurship skills, ethics, and professional moral and leadership skills. The Ministry of Higher Education, Malaysia recently announced that the said soft skills are to be introduced to undergraduates of Institutes of Higher Learning in Malaysia. Suggestions on how these elements are to be incorporated in the undergraduates program are also put forward.

Ionic conductivity by correlated barrier hopping in NH4I doped chitosan solid electrolyte

Abstract: Chitosan–NH 4 I and chitosan–NH 4 I–EC films have been prepared by solution cast technique. The sample containing 45 wt% ammonium iodide (NH 4 I) exhibited the highest room temperature conductivity of 3.7×10 −7 S cm −1 . The conductivity of the sample increased to 7.6×10 −6 S cm −1 when 40 wt% ethylene carbonate (EC) was added to the 55 wt% chitosan-45 wt% NH 4 I sample. The conductivity–temperature relationship is Arrhenian. From dielectric loss variation with frequency, the power law exponent was obtained. The temperature dependence of the power law exponent for chitosan–NH 4 I system follows the correlated barrier hopping (CBH) model while conduction mechanism of the plasticized system can be represented by the small polaron hopping (SPH) model.

Measurement of D ± and D 0 production in deep inelastic scattering using a lifetime tag at HERA

Abstract: The production of D-+/-- and D-0-mesons has been measured with the ZEUS detector at HERA using an integrated luminosity of 133.6 pb(-1). The measurements cover the kinematic range 5 < Q(2) < 1000 GeV2, 0.02 < y < 0.7, 1.5 < p(T)(D) < 15 GeV and |eta(D)| < 1.6. Combinatorial background to the D-meson signals is reduced by using the ZEUS microvertex detector to reconstruct displaced secondary vertices. Production cross sections are compared with the predictions of next-to-leading-order QCD, which is found to describe the data well. Measurements are extrapolated to the full kinematic phase space in order to obtain the open-charm contribution, F-2(c (c) over bar), to the proton structure function, F-2.

Virtual Teams: a Literature Review

Abstract: In the competitive market , virtual teams represent a growing response to the need for fasting time-to- market, low-cost and rapid solutions to complex organizational problems. Virtual teams enable organizations to pool the talents and expertise of employees and non-employees by eliminating time and space barriers . Nowadays, companies are heavily investing in virtual team to enhance their performance and competitiveness. Despite virtual teams growing prevalence, relatively little is known about this new form of team. Hence the study offers an extensive literature review with definitions o f virtual teams and a structured analysis of the present body of knowledge of virtual teams. First, we distinguish virtual teams from conventional teams , different types of virtual teams to identify where current knowledge applies. Second, we distinguish what is needed for effective virtual team considering the people, process and technology point of view and underlying characteristics of virtual teams and challenges they entail. Finally, we have identified an d extended 12 key factors that need to be considered, and describes a methodology focused on supporting virtual team working, with a new approach that has not been specifically addressed in the existing literature and some guide line for future research extracted.

Knowledge and awareness of cervical cancer and screening among Malaysian women who have never had a Pap smear: a qualitative study.

Abstract: The findings highlight the importance of emphasising accurate information about cervical cancer and the purpose of Pap smear screening when designing interventions aimed at improving cervical cancer screening for Malaysian women.

Optimization of the activity of CaO/Al2O3 catalyst for biodiesel production using response surface methodology

Abstract: In this work the response surface methodology (RSM) in conjunction with the central composite design (CCD) were used to optimize the activity of CaO/Al 2 O 3 solid catalysts for the production of biodiesel. In order to measure the catalyst activity, we used palm oil as a representative raw material for the conversion to biodiesel. The biodiesel production was carried out in a batch laboratory scale reactor. The results showed that both the calcination temperature and the amount of calcium oxide loaded on the support had significant positive effects on the biodiesel yield. The maximum basicity and biodiesel yield obtained were about 194 μmol/g and 94%, respectively. Overall, the catalyst showed high performance at moderate operating conditions and its activity was maintained after two cycles.

Environmental aspects and challenges of oilseed produced biodiesel in Southeast Asia

Abstract: Research on alternative fuel for the vehemently growing number of automotivesis intensified due to environmental reasons rather than turmoil in energy price and supply. From the policy and steps to emphasis the use of biofuel by governments all around the world, this can be comprehended that biofuel have placed itself as a number one substitute for fossil fuels. These phenomena made Southeast Asia a prominent exporter of biodiesel. But thrust in biodiesel production from oilseeds of palm and Jatropha curcas in Malaysia, Indonesia and Thailand is seriously threatening environmental harmony. This paper focuses on this critical issue of biodiesels environmental impacts, policy, standardization of this region as well as on the emission of biodiesel in automotive uses. To draw a bottom line on feasibilities of different feedstock of biodiesel, a critical analysis on oilseed yield rate, land use, engine emissions and oxidation stability is reviewed. Palm oil based biodiesel is clearly ahead in all these aspects of feasibility, except in the case of NOx where it lags from conventional petro diesel.

Effect of micro-powder suspension and ultrasonic vibration of dielectric fluid in micro-EDM processes—Taguchi approach

Abstract: Solutions are needed for increasing the material removal rate without degrading surface quality in micro-electrical discharge machining (μ-EDM). This paper presents a new method that consists of suspending micro-MoS 2 powder in dielectric fluid and using ultrasonic vibration during μ-EDM processes. The Taguchi method is adopted to ascertain the optimal process parameters to increase the material removal rate of dielectric fluid containing micro-powder in μ-EDM using a L 18 orthogonal array. Pareto analysis of variance is employed to analyze the four machining process parameters: ultrasonic vibration of the dielectric fluid, concentration of micro-powder, tool electrode materials, and workpiece materials. The results show that the introduction of MoS 2 micro-powder in dielectric fluid and using ultrasonic vibration significantly increase the material removal rate and improves surface quality by providing a flat surface free of black carbon spots.

A survey of image quality measures

Abstract: Image quality assessment is one of the challenging field of digital image processing system It can be done subjectively or objectively PSNR is the most popular and widely used objective image quality metric but it is not correlate well with the subjective assessment Thus, there are a lot of objective image quality metrics (IQM) developed in the past few decades to replace PSNR This paper provides a literature review of the current subjective and objective image quality measures The purpose of this paper is to collect reported quality metrics and group them according to their strategies and techniques

A survey on wireless security protocols (WEP, WPA and WPA2/802.11i)

Abstract: Wireless technology has been gaining rapid popularity for some years. Adaptation of a standard depends on the ease of use and level of security it provides. In this case, contrast between wireless usage and security standards show that the security is not keeping up with the growth paste of end user's usage. Current wireless technologies in use allow hackers to monitor and even change the integrity of transmitted data. Lack of rigid security standards has caused companies to invest millions on securing their wireless networks. There are three major types of security standards in wireless. In our previous papers which registered in ICFCC 2009 Malaysia and ICCDA 2009 Singapore [1] [2], we explained the structure of WEP and WPA as first and second wireless security protocols and discussed all their versions, problems and improvements. Now, we try to explain WPA2 versions, problems and enhancements that have done solve the WPA major weakness. Finally we make a comparison among WEP and WPA and WPA2 as all wireless security protocols in Wi-Fi technology. In the next phase we hope that we will publish a complete comparison among wireless security techniques by add the WiMax security technique and make a whole comparison among all security protocols in this area.