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Showing papers by "University of Malaya published in 2010"


Journal ArticleDOI
TL;DR: The influence of surface modification of activated carbon with gaseous ammonia on adsorption properties toward carbon dioxide (CO2) was reviewed in this paper, where two different methods, heat treatment and ammonia treatment (amination) for producing activated carbon had been compared and amination was found to be suitable modification technique for obtaining efficient CO2 adsorbents.

853 citations


Journal ArticleDOI
TL;DR: In this paper, a review of the development of metal or carbonaceous catalysts for enhanced methane conversion and on the improvement of long-term catalyst stability is presented, where the roles played by various parameters, such as temperature and flow rate, on the rate of hydrogen production and the characteristics of the carbon produced.

730 citations


Journal ArticleDOI
F. D. Aaron1, Halina Abramowicz2, I. Abt3, Leszek Adamczyk4  +538 moreInstitutions (69)
TL;DR: In this article, a combination of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised e(+/-)p scattering at HERA during the period 1994-2000 is presented.
Abstract: A combination is presented of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised e(+/-)p scattering at HERA during the period 1994-2000. The data span six orders of magnitude in negative four-momentum-transfer squared, Q(2), and in Bjorken x. The combination method used takes the correlations of systematic uncertainties into account, resulting in an improved accuracy. The combined data are the sole input in a NLO QCD analysis which determines a new set of parton distributions, HERAPDF1.0, with small experimental uncertainties. This set includes an estimate of the model and parametrisation uncertainties of the fit result.

624 citations


Journal ArticleDOI
TL;DR: Results indicated there were significant cross-regional differences in the ideal female figure and body dissatisfaction, but effect sizes were small across high-socioeconomic-status (SES) sites.
Abstract: This study reports results from the first International Body Project (IBP-I), which surveyed 7,434 individuals in 10 major world regions about body weight ideals and body dissatisfaction. Participants completed the female Contour Drawing Figure Rating Scale (CDFRS) and self-reported their exposure to Western and local media. Results indicated there were significant cross-regional differences in the ideal female figure and body dissatisfaction, but effect sizes were small across high-socioeconomic-status (SES) sites. Within cultures, heavier bodies were preferred in low-SES sites compared to high-SES sites in Malaysia and South Africa (ds = 1.94-2.49) but not in Austria. Participant age, body mass index (BMI), and Western media exposure predicted body weight ideals. BMI and Western media exposure predicted body dissatisfaction among women. Our results show that body dissatisfaction and desire for thinness is commonplace in high-SES settings across world regions, highlighting the need for international attention to this problem.

584 citations


Journal ArticleDOI
TL;DR: In this paper, the authors reviewed the technologies used for the biodiesel separation and purification, biodiesel quality, and its effects on diesel engines and found that the quality of biodiesel fuel is significant for its successful use on compression ignition engines and subsequent replacement of non-renewable fossil fuels.
Abstract: The continuous increasing demand for energy and the diminishing tendency of petroleum resources has led to the search for alternative renewable and sustainable fuel. Biodiesel is best substitute for petro-diesel and also most advantageous over petro-diesel for its environmental friendliness. The quality of biodiesel fuel was found to be significant for its successful use on compression ignition engines and subsequent replacement of non-renewable fossil fuels. Conventional biodiesel separation and purification technologies were noticed to yield lower quality biodiesel fuel with resultant excessive energy and water consumptions. Membrane technology showed more potential for effective and efficient separation and purification of biodiesel. This technology need be explored for the attainment of better quality biodiesel fuels. This paper reviews the technologies used for the biodiesel separation and purification, biodiesel quality, and its effects on diesel engines. Biodiesel biodegradability, lubricity, stability, economic importance, and gaseous emissions have been discussed.

558 citations


Journal ArticleDOI
TL;DR: In this paper, the mass of hydrogen-rich WN5−6 stars within the young star clusters NGC 3603 and R136 were analyzed using archival Hubble Space Telescope and Very Large Telescope spectroscopy, and high spatial resolution near-IR photometry, including MAD imaging of R136.
Abstract: Spectroscopic analyses of hydrogen-rich WN5‐6 stars within the young star clusters NGC 3603 and R136 are presented, using archival Hubble Space Telescope and Very Large Telescope spectroscopy, and high spatial resolution near-IR photometry, including MultiConjugate Adaptive Optics Demonstrator (MAD) imaging of R136. We derive high stellar temperatures for the WN stars in NGC 3603 (T∗ ∼ 42±2 kK) and R136 (T∗ ∼ 53± 3 kK) plus clumping-corrected mass-loss rates of 2 ‐ 5 ×10 −5 M⊙ yr −1 which closely agree with theoretical predictions from Vink et al. These stars make a disproportionate contribution to the global ionizing and mechanical wind power budget of their host clusters. Indeed, R136a1 alone supplies ∼7% of the ionizing flux of the entire 30 Doradus region. Compar isons with stellar models calculated for the main-sequence evolution of 85 ‐ 500 M⊙ accounting for rotation suggest ages of ∼1.5 Myr and initial masses in the range 105 ‐ 170 M⊙ for three systems in NGC 3603, plus 165 ‐ 320 M⊙ for four stars in R136. Our high stellar masses are supported by consistent spectroscopic and dynamical mass determinations for the components of NGC 3603 A1. We consider the predicted X-ray luminosity of the R136 stars if they were close, colliding wind binaries. R136c is consistent with a colliding wind binary system. However, short period, colliding wind systems are excluded for R136a WN stars if mass ratios are of order unity. Widely separated systems would have been expected to harden owing to early dynamical encounters with other massive stars within such a high density environment. From simulated star clusters, whose constituents are randomly sampled from the Kroupa initial mass function, both NGC 3603 and R136 are consistent with an tentative upper mass limit of ∼300 M⊙. The Arches cluster is either too old to be used to diagnose the upper mass limit, exhibits a deficiency of very massive stars, or mo re likely stellar masses have been underestimated ‐ initial masses for the most luminous stars in the Arches cluster approach 200 M⊙ according to contemporary stellar and photometric results. The potential for stars greatly exceeding 150 M⊙ within metal-poor galaxies suggests that such pair-instab ility supernovae could occur within the local universe, as has been claimed for SN 2007bi.

514 citations


Journal ArticleDOI
TL;DR: It has been proposed that the classification of d Dengue disease should be simplified as severe and non-severe dengue, which would make patient management and surveillance easier and permit early intervention to treat patients and prevent or control epidemics.
Abstract: Dengue is an arthropod-borne flavivirus that comprises four distinct serotypes (DEN-1, DEN-2, DEN-3 and DEN-4) that constitute an antigenic complex of the genus flavivirus, family Flaviviridae. Infection by one serotype induces life-long immunity against reinfection by the same serotype, but only transient and partial protection against infection with the other serotypes1,2. Dengue virus infections can result in a range of clinical manifestations from asymp tomatic infection to dengue fever (DF) and the severe disease dengue haemorrhagic fever/dengue shock syndrome (DHF/ DSS). Most dengue infections are asymptomatic or cause mild symptoms, which are characterized by undifferentiated fever with or without rash. Typical DF is characterized by high fever, severe headache, myalgia, arthralgia, retro-orbital pain and maculopapular rash. Some patients show petechiae, bruising or thrombocytopenia. The clinical presentation of acute dengue infection is non-specific but 5–10% of patients progress to severe DHF/DSS, which can result in death if it is not managed appropriately. Plasma extravasation is the main pathophysiological finding of DHF/ DSS, which differentiates it from DF. DHF/ DSS is characterized by high fever, bleeding, thrombocytopenia and haemoconcentration (an increase in the concentration of blood cells as a result of fluid loss). Approximately 3–4 days after the onset of fever, patients can present with petechiae, rash, epistaxis, and gingival and gastrointestinal bleeding. Pleural effusion and ascites are common. Some patients develop circulatory failure (DSS), presenting with a weak and fast pulse, narrowing of pulse pressure or hypotension, cold and moist skin and altered mental state. Although there are no specific antiviral treatments for dengue infection, patients usually recover when the need for fluid management is identified early and electrolytes are administered3. It has been proposed that the classification of dengue disease should be simplified as severe and non-severe dengue. This simplified classification would make patient management and surveillance easier4. There is a need for specific, inexpensive dengue diagnostic tests that can be used for clinical management, surveillance and outbreak investigations and would permit early intervention to treat patients and prevent or control epidemics. Progress is being made in primary prevention, with several candidate dengue vaccines in late phases of development as well as improved vector control measures. Additionally, new techniques for the early detection of severe disease such as the use of biomarkers have the potential to decrease morbidity and

489 citations


Journal ArticleDOI
TL;DR: Multifaceted, interdisciplinary approaches are urgently needed to achieve parity in health outcomes in HIV-infected drug users.

448 citations


Journal ArticleDOI
TL;DR: The HRAP using C. vulgaris offers a good system for the polishing of TW before final discharge and Supplementation of the TW with nutrients of Bold's Basal Medium increased biomass production but did not improve colour removal or reduction of pollutants.

446 citations


Journal ArticleDOI
TL;DR: In this paper, the authors focused on the application of ethylene glycol-based copper nanofluids in an automotive cooling system and found that about 3.8% of heat transfer enhancement could be achieved with the addition of 2% copper particles in a basefluid at the Reynolds number of 6000 and 5000 for air and coolant respectively.

406 citations


Journal ArticleDOI
TL;DR: A comprehensive literature review about electric motor energy analysis is presented in this article, where different types of losses that occur in a motor have been identified and ways to overcome these losses explained and an energy audit that helps to identify motor energy wastages have been discussed extensively.
Abstract: The industrial sector is the largest users of energy around the world. Industrial motor uses a major fraction of total industrial energy uses. This paper describes a comprehensive literature review about electric motor energy analysis. This paper compiles latest literatures in terms of thesis (MS and PhD), journal articles, conference proceedings, web materials, reports, books, handbooks on electrical motor energy use, losses, efficiency, energy savings strategies. Different types of losses that occur in a motor have been identified and ways to overcome these losses explained. An energy audit that helps to identify motor energy wastages have been discussed extensively. As motors are the major energy users, different energy savings strategies such as use of high-efficient motor, variable speed drive (VSD), and capacitor bank to improve the power factor to reduce their energy uses have reviewed. Different policy measures (i.e. regulatory, voluntary and incentives based) to save motor energy use have been reviewed and presented in this paper. In this review, computer tools that can be used to analyze electric motors energy used has been discussed. Cost parameters to carry out economic analysis have been shown as well. Moreover, payback period for different energy savings strategies have been identified.

Journal ArticleDOI
TL;DR: To determine the association between loss of muscle strength, mass, and quality and functional limitation and physical disability in older men, a large number of men aged 60 and over are surveyed.
Abstract: OBJECTIVES: To determine the association between loss of muscle strength, mass, and quality and functional limitation and physical disability in older men. DESIGN: Cross-sectional study of older men participating in the Concord Health and Ageing in Men Project (CHAMP). SETTING: Elderly men living in a defined geographical region in Sydney, Australia. PARTICIPANTS: One thousand seven hundred five community-dwelling men aged 70 and older who participated in the baseline assessments of CHAMP. MEASUREMENTS: Upper and lower extremity strength were measured using dynamometers for grip and quadriceps strength. Appendicular skeletal lean mass was assessed using dual X-ray absorptiometry. Muscle quality was defined as the ratio of strength to mass in upper and lower extremities. For each parameter, subjects in the lowest 20% of the distribution were defined as below normal. Functional limitation was assessed according to self-report and objective lower extremity performance measures. Physical disability was measured according to self-report questionnaire. RESULTS: After adjusting for important confounders, the prevalence ratio (PR) for poor quadriceps strength and self-reported functional limitation was 1.91 (95% confidence interval (CI) 51.10-2.40); for performance-based functional limitation the PR was 1.81 (95% CI = 1.45-2.24). The adjusted PR for poor grip strength and physical disability in instrumental activities of daily living (IADLs) was 1.37 (95% CI = 1.20-1.56). The adjusted PR for low skeletal lean mass (adjusted for fat mass) and physical disability in basic activities of daily living was 2.08 (95% CI = 1.37-3.15). For muscle quality, the PR for lower extremity specific force and functional limitation and physical disability was stronger than upper extremity specific force. CONCLUSION: Muscle strength is the single best measure of age-related muscle change and is associated with physical disability in IADLs and functional limitation. J Am Geriatr Soc 58:2055-2062, 2010.

Journal ArticleDOI
TL;DR: It is suggested that the prevalence of premature ejaculation is considerably lower than previously thought and that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction.

Journal ArticleDOI
TL;DR: In this paper, the authors explored the wind energy industry from the point of view of wind energy policy and found that energy policy could help increasing wind power generation as well as stimulating the energy industry.
Abstract: With the increasing negative effects of fossil fuel combustion on the environment in addition to limited stock of fossil fuel have forced many countries to inquire into and change to environmentally friendly alternatives that are renewable to sustain the increasing energy demand. Energy policy plays a vital role to mitigate the impacts of global warming and crisis of energy availability. This paper explores the wind energy industry from the point of view of the wind energy policy. It is noticed that energy policy could help increasing wind power generation as well as stimulating the energy industry. It may be stated that without specific energy policy, a country would not be able to solve the acute problems like reducing greenhouse gases (GHGs) emission, scarcity of energy, etc. This paper discussed the existing successful energy policies for few selected countries. Based on literatures, it has been found that FIT, RPS, incentives, pricing law and Quota system are the most useful energy policies practiced by many countries around the world. Then, status of wind energy policy for Malaysia was investigated and compared with few selected countries around the world.

Journal ArticleDOI
TL;DR: In this article, a comprehensive literature review about compressed air energy use, savings, and payback period of energy efficient strategies is presented, where various energy-saving measures, such as use of highly efficient motors, VSD, leak prevention, use of outside intake air, reducing pressure drop, recovering waste heat, and use of variable displacement compressor to save compressed-air energy have been reviewed.
Abstract: Compressed-air systems account for about 10% of total industrial-energy use for few selected countries as found in literatures. Compressed air is typically one of the most expensive utilities in an industrial facility. This paper describes a comprehensive literature review about compressed air energy use, savings, and payback period of energy efficient strategies. This paper compiles latest literatures in terms of thesis (MS and PhD), journal articles, conference proceedings, web materials, reports, books, handbooks on compressed air energy use, efficiency, energy savings strategies. Computer tools for compressed air analysis have been reviewed and presented in this paper. Various energy-saving measures, such as use of highly efficient motors, VSD, leak prevention, use of outside intake air, reducing pressure drop, recovering waste heat, use of efficient nozzle, and use of variable displacement compressor to save compressed-air energy have been reviewed. Based on review results, it has been found that for an electric motor used in a compressed-air system, a sizeable amount of electric energy and utility bill can be saved using high efficient motors and applying VSDs in matching speed requirements. Also, significant amounts of energy and emission are reducible through various energy-saving strategies. Payback periods for different energy savings measures have been identified and found to be economically viable in most cases.

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the relationship between electricity consumption and real gross domestic product (GDP) for Malaysia in a bivariate and multivariate framework and found that electricity consumption, real GDP and price share a long-run relationship.

Journal ArticleDOI
TL;DR: In this paper, the properties of rice husk ash (RHA) produced by using a ferro-cement furnace were investigated, and the effect of grinding on the particle size and the surface area was first investigated, then the XRD analysis was conducted to verify the presence of amorphous silica in the ash.
Abstract: This paper investigates the properties of rice husk ash (RHA) produced by using a ferro-cement furnace. The effect of grinding on the particle size and the surface area was first investigated, then the XRD analysis was conducted to verify the presence of amorphous silica in the ash. Furthermore, the effect of RHA average particle size and percentage on concrete workability, fresh density, superplasticizer (SP) content and the compressive strength were also investigated. Although grinding RHA would reduce its average particle size (APS), it was not the main factor controlling the surface area and it is thus resulted from RHA's multilayered, angular and microporous surface. Incorporation of RHA in concrete increased water demand. RHA concrete gave excellent improvement in strength for 10% replacement (30.8% increment compared to the control mix), and up to 20% of cement could be valuably replaced with RHA without adversely affecting the strength. Increasing RHA fineness enhanced the strength of blended concrete compared to coarser RHA and control OPC mixtures.

Journal ArticleDOI
TL;DR: Analysis of this large, prospectively collected data set confirms the response to chelation therapy across various anemias, supporting initial deferasirox doses based on transfusional iron intake, with subsequent dose titration guided by trends in serum ferritin and safety markers.
Abstract: Background Following a clinical evaluation of deferasirox (Exjade®) it was concluded that, in addition to baseline body iron burden, ongoing transfusional iron intake should be considered when selecting doses. The 1-year EPIC study, the largest ever investigation conducted for an iron chelator, is the first to evaluate whether fixed starting doses of deferasirox, based on transfusional iron intake, with dose titration guided by serum ferritin trends and safety markers, provides clinically acceptable chelation in patients (aged ≥2 years) with transfusional hemosiderosis from various types of anemia.Design and Methods The recommended initial dose was 20 mg/kg/day for patients receiving 2–4 packed red blood cell units/month and 10 or 30 mg/kg/day was recommended for patients receiving less or more frequent transfusions, respectively. Dose adjustments were based on 3-month serum ferritin trends and continuous assessment of safety markers. The primary efficacy end-point was change in serum ferritin after 52 weeks compared with baseline.Results The 1744 patients enrolled had the following conditions; thalassemia (n=1115), myelodysplastic syndromes (n=341), aplastic anemia (n=116), sickle cell disease (n=80), rare anemias (n=43) and other transfused anemias (n=49). Overall, there was a significant reduction in serum ferritin from baseline (−264 ng/mL; P5%) adverse events were gastrointestinal disturbances (28%) and skin rash (10%).Conclusions Analysis of this large, prospectively collected data set confirms the response to chelation therapy across various anemias, supporting initial deferasirox doses based on transfusional iron intake, with subsequent dose titration guided by trends in serum ferritin and safety markers (clinicaltrials.gov identifier: NCT00171821).

Journal ArticleDOI
TL;DR: A single-phase multistring five-level photovoltaic (PV) inverter topology for grid-connected PV systems with a novel pulsewidth-modulated (PWM) control scheme that offers much less total harmonic distortion and can operate at near-unity power factor.
Abstract: This paper presents a single-phase multistring five-level photovoltaic (PV) inverter topology for grid-connected PV systems with a novel pulsewidth-modulated (PWM) control scheme. Three PV strings are cascaded together in parallel configuration and connected to a five-level inverter to produce output voltage in five levels: zero, +1/2V dc, V dc, -1/2V dc, and -V dc. Two reference signals that were identical to each other with an offset that was equivalent to the amplitude of the triangular carrier signal were used to generate PWM signals for the switches. DSP TMS320F2812 is used to implement this PWM switching scheme together with a digital proportional-integral current control algorithm. The inverter offers much less total harmonic distortion and can operate at near-unity power factor. The validity of the proposed inverter is verified through simulation and implemented in a prototype. The experimental results are compared with a conventional single-phase multistring three-level grid-connected PWM inverter.

Journal ArticleDOI
TL;DR: In this paper, a quaternary ammonium salt-glycerine-based ionic liquid is proposed as a solvent for extracting glycerine from the transesterification biodiesel product.

Journal ArticleDOI
TL;DR: Honey methanol extract exhibited greater activity in vitro, whereas HME contained a higher concentration of phenolic compounds per 100 g of honey, indicating that these extracts possess different in vitro anti-inflammatory activities.

Journal ArticleDOI
TL;DR: Two quadratic models were developed for yield of activated carbon and adsorption of malachite green oxalate using Design-Expert software and showed an excellent agreement with the amounts predicted by the models.

Journal ArticleDOI
TL;DR: In this paper, the useful concept of energy and exergy utilization is analyzed, and applied to the boiler system, and the energy and energy exergy flows in a boiler have been shown in this paper.

Journal ArticleDOI
TL;DR: In this article, the authors focused on the transport studies of PVA-chitosan blended electrolyte system and application in proton batteries and obtained a 2.07 × 10−5 Sc m−1.

Journal ArticleDOI
TL;DR: This article studied the return predictability of the Dow Jones Industrial Average indices from 1900 to 2009 and found strong evidence that time-varying return prediction is driven by changing market conditions, consistent with the implications of the adaptive markets hypothesis.
Abstract: We study return predictability of the Dow Jones Industrial Average indices from 1900 to 2009. We find strong evidence that time-varying return predictability is driven by changing market conditions, consistent with the implications of the adaptive markets hypothesis. During market crashes, no return predictability is observed, but an extreme degree of uncertainty is associated with return predictability. During fundamental economic or political crises, stock returns have been highly predictable with a moderate degree of uncertainty. During economic bubbles, return predictability and its uncertainty have been smaller than normal times.

Journal ArticleDOI
TL;DR: The effect of geometrical parameters on water flow and heat transfer characteristics in microchannels is numerically investigated for Reynolds number range of 100-1000 in this article, where three different shapes of microchannel heat sinks are investigated.

Proceedings ArticleDOI
28 May 2010
TL;DR: In this paper, the authors present a model design method for the flight control of an autonomous quad rotor, which is an under-actuated aircraft with fixed four pitch angle rotors.
Abstract: This paper presents the modelling of a four rotor vertical take-off and landing (VTOL) unmanned air vehicle known as the quadrotor aircraft. The paper presents a new model design method for the flight control of an autonomous quad rotor. The paper describes the controller architecture for the quadrotor as well. The dynamic model of the quad-rotor, which is an under actuated aircraft with fixed four pitch angle rotors, will be described. The Modeling of a quadrotor vehicle is not an easy task because of its complex structure. The aim is to develop a model of the vehicle as realistic as possible. The model is used to design a stable and accurate controller. This paper explains the developments of a PID (proportionalintegral-derivative) control method to obtain stability in flying the Quad-rotor flying object. The model has four input forces which are basically the thrust provided by each propeller connected to each rotor with fixed angle. Forward (backward) motion is maintained by increasing (decreasing) speed of front (rear) rotor speed while decreasing (increasing) rear (front) rotor speed simultaneously which means changing the pitch angle. Left and right motion is accomplished by changing roll angle by the same way. The front and rear motors rotate counter-clockwise while other motors rotate clockwise so that the yaw command is derived by increasing (decreasing) counter-clockwise motors speed while decreasing (increasing) clockwise motor speeds.

Journal ArticleDOI
TL;DR: In this paper, the spatial patterns of annual and seasonal rainfall trends of Bangladesh over the time period 1958-2007 have been assessed using rainfall data recorded at 17 stations distributed over the country.
Abstract: Spatial patterns of annual and seasonal rainfall trends of Bangladesh over the time period 1958–2007 has been assessed using rainfall data recorded at 17 stations distributed over the country. Mann–Kendall trend test and the Sen's slope method are used to detect the significance and the magnitude of rainfall change, respectively. Historical dry and wet months are identified by using standardised precipitation index method and their trends are analysed to assess the possible change in wet and dry events in Bangladesh. The result shows a significant increase in the average annual and pre-monsoon rainfall of Bangladesh. The number of wet months is found to increase and the dry months to decrease in most parts of the country. Seasonal analysis of wet and dry months shows a significant decrease of dry months in monsoon and pre-monsoon. Copyright © 2009 Royal Meteorological Society

Journal ArticleDOI
TL;DR: The consequences of the evolutionary dynamics of EV-71 for vaccine design and compare its phylodynamic behavior with that of influenza virus are discussed and its phylogenetic and population genetic methods are analyzed.
Abstract: Human enterovirus 71 (EV-71) is one of the major etiologic causes of hand, foot, and mouth disease (HFMD) among young children worldwide, with fatal instances of neurological complications becoming increasingly common. Global VP1 capsid sequences (n 628) sampled over 4 decades were collected and subjected to comprehensive evolutionary analysis using a suite of phylogenetic and population genetic methods. We estimated that the common ancestor of human EV-71 likely emerged around 1941 (95% confidence interval [CI], 1929 to 1952), subsequently diverging into three genogroups: B, C, and the now extinct genogroup A. Genealogical analysis revealed that diverse lineages of genogroup B and C (subgenogroups B1 to B5 and C1 to C5) have each circulated cryptically in the human population for up to 5 years before causing large HFMD outbreaks, indicating the quiescent persistence of EV-71 in human populations. Estimated phylogenies showed a complex pattern of spatial structure within well-sampled subgenogroups, suggesting endemicity with occasional lineage migration among locations, such that past HFMD epidemics are unlikely to be linked to continuous transmission of a single strain of virus. In addition, rises in genetic diversity are correlated with the onset of epidemics, driven in part by the emergence of novel EV-71 subgenogroups. Using subgenogroup C1 as a model, we observe temporal strain replacement through time, and we investigate the evidence for positive selection at VP1 immunogenic sites. We discuss the consequences of the evolutionary dynamics of EV-71 for vaccine design and compare its phylodynamic behavior with that of influenza virus.

Journal ArticleDOI
TL;DR: There is no compelling evidence that testosterone treatment causes prostate cancer or its progression in men without severe testosterone deficiency (TD), and men with erectile dysfunction, hypoactive sexual desire and retarded ejaculation, as well as those with visceral obesity and metabolic diseases, should be screened for TD and treated.