Showing papers by "University of Malaya published in 2016"

Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.

Abstract: Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous APASL guidelines for management of HBV infection were published in 2012. The objective of this manuscript is to update the recommendations for the optimal management of chronic HBV infection. The 2015 guidelines were developed by a panel of Asian experts chosen by the APASL. The clinical practice guidelines are based on evidence from existing publications or, if evidence was unavailable, on the experts' personal experience and opinion after deliberations. Manuscripts and abstracts of important meetings published through January 2015 have been evaluated. This guideline covers the full spectrum of care of patients infected with hepatitis B, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of the stage of liver disease, the indications, timing, choice and duration of single or combination of antiviral drugs, screening for HCC, management in special situations like childhood, pregnancy, coinfections, renal impairment and pre- and post-liver transplant, and policy guidelines. However, areas of uncertainty still exist, and clinicians, patients, and public health authorities must therefore continue to make choices on the basis of the evolving evidence. The final clinical practice guidelines and recommendations are presented here, along with the relevant background information.

A century of trends in adult human height

Abstract: Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3–19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8–144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Abstract: Collagen and elastin networks make up the majority of the extracellular matrix in many organs, such as the skin. The mechanisms which are involved in the maintenance of homeostatic equilibrium of these networks are numerous, involving the regulation of genetic expression, growth factor secretion, signalling pathways, secondary messaging systems, and ion channel activity. However, many factors are capable of disrupting these pathways, which leads to an imbalance of homeostatic equilibrium. Ultimately, this leads to changes in the physical nature of skin, both functionally and cosmetically. Although various factors have been identified, including carcinogenesis, ultraviolet exposure, and mechanical stretching of skin, it was discovered that many of them affect similar components of regulatory pathways, such as fibroblasts, lysyl oxidase, and fibronectin. Additionally, it was discovered that the various regulatory pathways intersect with each other at various stages instead of working independently of each other. This review paper proposes a model which elucidates how these molecular pathways intersect with one another, and how various internal and external factors can disrupt these pathways, ultimately leading to a disruption in collagen and elastin networks.

Effect of process parameters on production of biochar from biomass waste through pyrolysis: A review

Abstract: Biomass is considered to have potential to be used as an alternative energy source. High carbon content present in biomass converts it into high energy biochar on thermochemical treatment. Among few well established thermochemical technologies for the treatment of biomass and biogenic waste to produce high energy char along with oil and gaseous yield, pyrolysis is the most studied and discussed technique in the recent past. A comparison between the existing techniques is established in the present work. Production of char from the biomass and biogenic wastes is reviewed and it was found that yield of the biochar depends upon the biomass composition like moisture content and presence of cellulose or lignin. Pyrolysis product distribution and their quality strongly depend upon the process parameters. Different biomasses which can be used as raw material in pyrolysis are also reviewed and categorized depending upon their source. Pyrolysis process parameters such as temperature, heating rate, residence time etc. also influence the biochar yield. This study discusses the effect of these process parameters on the production of biochar through pyrolysis of biomass.

Role of Plant Growth Promoting Rhizobacteria in Agricultural Sustainability-A Review.

Abstract: Plant growth promoting rhizobacteria (PGPR) shows an important role in the sustainable agriculture industry. The increasing demand for crop production with a significant reduction of synthetic chemical fertilizers and pesticides use is a big challenge nowadays. The use of PGPR has been proven to be an environmentally sound way of increasing crop yields by facilitating plant growth through either a direct or indirect mechanism. The mechanisms of PGPR include regulating hormonal and nutritional balance, inducing resistance against plant pathogens, and solubilizing nutrients for easy uptake by plants. In addition, PGPR show synergistic and antagonistic interactions with microorganisms within the rhizosphere and beyond in bulk soil, which indirectly boosts plant growth rate. There are many bacteria species that act as PGPR, described in the literature as successful for improving plant growth. However, there is a gap between the mode of action (mechanism) of the PGPR for plant growth and the role of the PGPR as biofertilizer—thus the importance of nano-encapsulation technology in improving the efficacy of PGPR. Hence, this review bridges the gap mentioned and summarizes the mechanism of PGPR as a biofertilizer for agricultural sustainability.

Event generator tunes obtained from underlying event and multiparton scattering measurements

Abstract: New sets of parameters ("tunes") for the underlying-event (UE) modeling of the PYTHIA8, PYTHIA6 and HERWIG++ Monte Carlo event generators are constructed using different parton distribution functions. Combined fits to CMS UE data at sqrt(s) = 7 TeV and to UE data from the CDF experiment at lower sqrt(s), are used to study the UE models and constrain their parameters, providing thereby improved predictions for proton-proton collisions at 13 TeV. In addition, it is investigated whether the values of the parameters obtained from fits to UE observables are consistent with the values determined from fitting observables sensitive to double-parton scattering processes. Finally, comparisons of the UE tunes to "minimum bias" (MB) events, multijet, and Drell-Yan (q q-bar to Z / gamma* to lepton-antilepton + jets) observables at 7 and 8 TeV are presented, as well as predictions of MB and UE observables at 13 TeV.

Power loss due to soiling on solar panel: A review

Abstract: The power output delivered from a photovoltaic module highly depends on the amount of irradiance, which reaches the solar cells. Many factors determine the ideal output or optimum yield in a photovoltaic module. However, the environment is one of the contributing parameters which directly affect the photovoltaic performance. The authors review and evaluate key contributions to the understanding, performance effects, and mitigation of power loss due to soiling on a solar panel. Electrical characteristics of PV (Voltage and current) are discussed with respect to shading due to soiling. Shading due to soiling is divided in two categories, namely, soft shading such as air pollution, and hard shading which occurs when a solid such as accumulated dust blocks the sunlight. The result shows that soft shading affects the current provided by the PV module, but the voltage remains the same. In hard shading, the performance of the PV module depends on whether some cells are shaded or all cells of the PV module are shaded. If some cells are shaded, then as long as the unshaded cells receive solar irradiance, there will be some output although there will be a decrease in the voltage output of the PV module. This study also present a few cleaning method to prevent from dust accumulation on the surface of solar arrays.

Macroalgae and microalgae as a potential source for commercial applications along with biofuels production: A biorefinery approach

Abstract: Due to diminishing petroleum reserves and deleterious environmental consequences of exhaust gases from fossil-based fuels, research on renewable and environment friendly fuels has received a lot of impetus in the recent years. However, the availability of the non-edible crops serve as the sources for biofuel production are limited and economically not feasible. Algae are a promising alternative source to the conventional feedstocks for the third generation biofuel production. There has been a considerable discussion in the recent years about the potential of microalgae for the production of biofuels, but there may be other more readily exploitable commercial opportunities for macroalgae and microalgae. This review, briefly describes the biofuels conversion technologies for both macroalgae and microalgae. The gasification process produces combustible gases such as H2, CH4, CO2 and ammonia, whereas, the product of pyrolysis is bio-oil. The fermentation product of algae is ethanol, that can be used as a direct fuel or as a gasohol. Hydrogen can be obtained from the photobiological process of algal biomass. In transesterification process, algae oil is converted into biodiesel, which is quite similar to those of conventional diesel and it can be blended with the petroleum diesel. This study, also reviewed the production of high value byproducts from macroalgae and microalgae and their commercial applications. Algae as a potential renewable resource is not only used for biofuels but also for human health, animal and aquatic nutrition, environmental applications such as CO2 mitigation, wastewater treatment, biofertilizer, high-value compounds, synthesis of pigments and stable isotope biochemicals. This review is mainly an attempt, to investigate the biorefinery concept applied on the algal technology, for the synthesis of novel bioproducts to improve the algal biofuels as even more diversified and economically competitive. The employment of a high-value, co-product strategy through the integrated biorefinery approach is expected to significantly enhance the overall commercial implementation of the biofuel from the algal technology.

Fuel ethanol production from lignocellulosic biomass: an overview on feedstocks and technological approaches.

Abstract: Bioethanol is one of the most promising and eco-friendly alternatives to fossil fuels, which is produced from renewable sources. Although almost all the current fuel ethanol is generated from edible sources (sugars and starch), lignocellulosic biomass (LCB) has drawn much attention in recent times. However, the conversion efficiency as well as ethanol yield of the biomass differs greatly with respect to the source and nature of LCB, primarily due to the variation in lignocellulosic content. Two major polysaccharides in LCB, namely, cellulose and hemicellulose firmly link to lignin and form a complex lignocellulosic network, which is highly robust and recalcitrant to depolymerization. For this reason, generation of ethanol from LCB requires a complicated conversion process that has made it commercially non-competitive. As attempts to exploit LCBs into commercial ethanol production, recent research efforts have been devoted to the techno-economic improvements of the overall conversion process, in addition to screen out promising feedstocks. This review paper presents an overview on the diversity of biomass, technological approaches and microbial contribution to the conversion of LCB into ethanol.

A survey on mobile edge computing

Abstract: Mobile Edge Computing is an emerging technology that provides cloud and IT services within the close proximity of mobile subscribers. Traditional telecom network operators perform traffic control flow (forwarding and filtering of packets), but in Mobile Edge Computing, cloud servers are also deployed in each base station. Therefore, network operator has a great responsibility in serving mobile subscribers. Mobile Edge Computing platform reduces network latency by enabling computation and storage capacity at the edge network. It also enables application developers and content providers to serve context-aware services (such as collaborative computing) by using real time radio access network information. Mobile and Internet of Things devices perform computation offloading for compute intensive applications, such as image processing, mobile gaming, to leverage the Mobile Edge Computing services. In this paper, some of the promising real time Mobile Edge Computing application scenarios are discussed. Later on, a state-of-the-art research efforts on Mobile Edge Computing domain is presented. The paper also presents taxonomy of Mobile Edge Computing, describing key attributes. Finally, open research challenges in successful deployment of Mobile Edge Computing are identified and discussed.

Epstein-Barr virus: more than 50 years old and still providing surprises

Abstract: It is more than 50 years since the Epstein-Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV has revealed fundamental mechanisms of more general relevance to the oncogenic process. This Timeline article highlights key milestones in the 50-year history of EBV and discusses how this virus provides a paradigm for exploiting insights at the molecular level in the diagnosis, treatment and prevention of cancer.

Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line

Abstract: Periodontal disease represents a group of oral inflammatory infections initiated by oral pathogens which exist as a complex biofilms on the tooth surface and cause destruction to tooth supporting tissues. The severity of this disease ranges from mild and reversible inflammation of the gingiva (gingivitis) to chronic destruction of connective tissues, the formation of periodontal pocket and ultimately result in loss of teeth. While human subgingival plaque harbors more than 500 bacterial species, considerable research has shown that Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is the major etiologic agent which contributes to chronic periodontitis. This black-pigmented bacterium produces a myriad of virulence factors that causes destruction to periodontal tissue either directly or indirectly by modulating the host inflammatory response. Here, this review provides an overview of P. gingivalis and how its virulence factors contribute to the pathogenesis with other microbiome consortium in oral cavity.

Flexible Graphene-Based Supercapacitors: A Review

Abstract: The recent rapid growth in graphene-based supercapacitors has reached the point where there is a need for solid-state devices with physical flexibility, which will be a crucial advantage in modern electronic devices. Herein, we summarize recent developments toward an all solid-state graphene-based flexible supercapacitor. The routes to produce graphene-based electrode materials, along with the typical fabrication techniques for flexible devices, are thoroughly discussed. Furthermore, the structural morphology of the electrode materials is closely related to the electrochemical performance, and the influence of the electrode components on the mechanical flexibility of the fabricated devices is examined. Lastly, a summary of the overall electrochemical properties and current development of the reported devices is presented progressively to predict the future trends toward the realization of an ultimate-performance graphene-based flexible supercapacitor.

Second generation bioethanol production: A critical review

Abstract: It is a popular fact that the world's dependency on fossil fuel has caused unfavourable effects, including lessening crude oil reserve, decreasing air quality, rising global temperature, unpredictable weather change, and so on. As the effort to promote sustainability and independency from fossil fuel, bioethanol is now favoured as the blend or fossil petrol substitute. However, the feedstock functionality of first generation bioethanol production is restricted due to its edibleness since it would clash the feeding purpose. Second generation bioethanol production fulfils the impractical gap of first generation since it employs non-edible feedstock sourced from agriculture and forestry wastes. Lignocellulosic and starchy materials in them are convertible to fermentable sugars that are able to be further processed, resulting anhydrous bioethanol as the end product. This paper critically reviews the existing variance of second generation bioethanol production methodologies, namely pre-treatment, hydrolysis, fermentation and distillation, as well as the worth of second generation production for future reference. The discussions in this paper are also fit as the fundamental for feasible planning of second generation bioethanol production plant.

A review of polymer electrolytes: fundamental, approaches and applications

Abstract: In this paper, we review different types of polymer electrolytes, recent approaches and technological applications of polymer electrolytes. The report first discusses the characteristics, advantages and applications for three types of polymer electrolytes: gel polymer electrolytes, solid polymer electrolytes and composite polymer electrolytes. Next, we discuss the features and performance of different polymer hosts based on some important and recently published literature. Recent progress of some approaches used in improving the performance of the polymer electrolytes is highlighted. The last part of the review includes the technological applications of some electrical energy storing/converting devices: electrochemical capacitors, batteries, fuel cells and dye-sensitized solar cells. It is also stressed that the technological advancement in the polymer electrolytes plays a pivotal role in the development of energy storing/converting systems.

Microalgae biofuels as an alternative to fossil fuel for power generation

Abstract: Biofuels productions from microalgae received wide attention recently and have high potential to replace fossil fuels. This paper served as a platform to critically review current production technologies of microalgae, ranging from cultivation, harvesting, extraction and several biofuels conversion processes. In addition, due to the high photosynthetic efficiency of microalgae, mass cultivation of microalgae is believed to be able to efficiently reduce the carbon dioxide emission to atmosphere and thus, reducing the impact of global warming. This is because microalgae have high growth rate and is able to develop maximum of 70% of lipid content within their cells depending on species. Apart from that, microalgae have the ability to survive under harsh condition and occupied smaller cultivation land area than other land crops. The harvested microalgae biomass can be used for electrical generation, while its crude lipid can be used as transportation fuel as it has 80% average energy content of petroleum. In the present paper, a detailed discussion to produce biodiesel, fuel gas, bio-oil, methane, hydrogen and alcohol from microalgae biomass are also included. Besides, updated research, challenges and the way forward of microalgae biofuels are also presented. In future, biofuels production from microalgae can be economical viable at some scale, which is then profitable in terms of economics and also environment.

Energy management strategies in hybrid renewable energy systems: A review

Abstract: Variability and intermittency are some of the main features that characterize renewable energy sources. Intermittency usually includes both predictable and unpredictable variations. The many drawbacks of intermittency of renewable sources can be overcome by considering some special design considerations. Integrating more than one renewable energy source and including backup sources and storage systems are among the few measures to overcome these drawbacks. These additional design considerations usually increase the overall cost of the renewable system. Furthermore, the presence of more than one energy supply/storage system requires the control of energy flow among the various sources. Therefore, optimizing the size of the components and adopting an energy management strategy (EMS) are essential to decreasing the cost of the system and limiting its negative effects. The energy management strategy is commonly integrated with optimization to ensure the continuity of load supply and to decrease the cost of energy production. Therefore, energy management is a term that collects all the systematic procedures to control and minimize the quantity and the cost of energy used to provide a certain application with its requirements. The energy management strategy usually depends on the type of energy system and its components. Various approaches and techniques have been used to develop a successful energy management strategy. In this paper, a comprehensive review of the approaches proposed and used by authors of many papers is conducted. These approaches include both the standalone hybrid renewable energy systems and the grid-connected hybrid renewable systems. More attention is focused on popularly used techniques to address the features of each system. The selected papers in this review cover the various configurations of the hybrid renewable energy systems for electric power generation only.

Preliminary assessment of heavy metals in water and sediment of Karnaphuli River, Bangladesh

Abstract: Contamination of heavy metals in sediment is regarded as a global crisis with a large share in developing countries like Bangladesh. Four heavy metals such as arsenic (As), chromium (Cr), cadmium (Cd) and lead (Pb) in sediments and water were investigated from Karnaphuli River in Bangladesh. The decreasing trend of metals were observed in water as Cr > As > Pb > Cd and in sediment Cr > Pb > As > Cd. The ranges of heavy metals in water were 13.31–53.87, 46.09–112.43, 2.54–18.34 and 5.29–27.45 μg/L and in sediments were 11.56–35.48, 37.23–160.32, 0.63–3.56 and 21.98–73.42 mg/kg for As, Cr, Cd and Pb. The level of studied metals in water samples exceeded the safe limits of drinking water, indicated that water from this river is not safe for drinking and/or cooking. Contamination factor (CF) confirmed that the sediment samples were moderate to high contamination by As, Cd and Pb. The pollution load index (PLI) values were above one (>1) indicates advanced decline of the sediment quality. This study recommended that continuous monitoring of As, Cd and Pb in water; sediment and other aquatic biota of Karnaphuli River should be directed to assess the risk of these vital metals to safe the ecology in the vicinity of this river.

A Survey of Mobile Device Virtualization: Taxonomy and State of the Art

Abstract: Recent growth in the processing and memory resources of mobile devices has fueled research within the field of mobile virtualization. Mobile virtualization enables multiple persona on a single mobile device by hosting heterogeneous operating systems (OSs) concurrently. However, adding a virtualization layer to resource-constrained mobile devices with real-time requirements can lead to intolerable performance overheads. Hardware virtualization extensions that support efficient virtualization have been incorporated in recent mobile processors. Prior to hardware virtualization extensions, virtualization techniques that are enabled by performance prohibitive and resource consuming software were adopted for mobile devices. Moreover, mobile virtualization solutions lack standard procedures for device component sharing and interfacing between multiple OSSs. The objective of this article is to survey software- and hardware-based mobile virtualization techniques in light of the recent advancements fueled by the hardware support for mobile virtualization. Challenges and issues faced in virtualization of CPU, memory, I/O, interrupt, and network interfaces are highlighted. Moreover, various performance parameters are presented in a detailed comparative analysis to quantify the efficiency of mobile virtualization techniques and solutions.

Photovoltaic penetration issues and impacts in distribution network - A review

Abstract: The solar energy generation has grown significantly in the past years. The importance of PV penetration in power system as a major element of renewable energy source has seen it being widely used on a global scale. Despite its promising success, PV penetration presents various issues and its impact on the distribution system has to address for seamless integration in the power system. In this paper, a comprehensive overview on important issues affecting the distribution system as a result of PV penetration is presented. Pertinent issues such as voltage fluctuation, voltage rise, voltage balance, and harmonics and their effect on the system are discussed in details. The islanding issues, which are of critical importance to the stability and integrity of the system, are also thoroughly reviewed. Details on different islanding techniques – remote and local techniques and their advantage and disadvantages are shown. Therefore, this paper can provide useful information and serve as a reference for researchers and utility engineers on issues to be considered with regards to PV penetration.

Solar cell parameters extraction based on single and double-diode models: A review

Abstract: This paper comprehensively describes and discusses the extraction of the DC parameters of solar cells by mathematical techniques based on single-diode and double-diode models. The main parameters of interest are the photocurrent, Iph, the reverse diode saturation current, Io, the ideality factor of diode, n, the series resistance, RS, and the shunt resistance, RSh. This paper reviews the foremost issues of the condition of the methodologies of the extraction of PV solar cell parameters. This paper classifies the reviewed models on the basis of the number of extracted parameters and provides specific comments for each model. Five parameters from different models that have identical attributes are characterized with respect to irradiance and temperature to demonstrate the behavior and characteristics of these parameters. In addition, this article implements two real models, single-diode and double-diode models, and examines the performance of the PV parameters for each model and its effect on the current–voltage (I–V) and power–voltage (P–V) characteristics. Furthermore, to assess the accuracy of each model with respect to the data provided by the manufacturer, this paper compares the I–V and P–V curves at standard test condition (STC) and for different parameters for a generic PV panel.

The Long-Term Public Health Benefits of Breastfeeding.

Abstract: Breastfeeding has many health benefits, both in the short term and the longer term, to infants and their mothers. There is an increasing number of studies that report on associations between breastfeeding and long-term protection against chronic disease. Recent research evidence is reviewed in this study, building on previous authoritative reviews. The recent World Health Organization reviews of the short- and long-term benefits of breastfeeding concluded that there was strong evidence for many public health benefits of breastfeeding. Cognitive development is improved by breastfeeding, and infants who are breastfed and mothers who breastfeed have lower rates of obesity. Other chronic diseases that are reduced by breastfeeding include diabetes (both type 1 and type 2), obesity, hypertension, cardiovascular disease, hyperlipidemia, and some types of cancer.

A comprehensive review on properties of edible and non-edible vegetable oil-based biodiesel: Composition, specifications and prediction models

Abstract: In recent decades, the concern over depletion of the world׳s petroleum reserves and environmental pollution has increased the demand to develop a renewable and environmental friendly fuel. Biodiesel, which mainly consists of Fatty Acid Methyl Esters (FAME) is one of the best substitutes for diesel fuel. Currently, vegetable oils, edible or non-edible, are the main resources of biodiesel. This review aims at providing comprehensive information and analyzes on biodiesel produced from edible and non-edible vegetable oils, their composition and specifications. Accordingly, the Fatty Acid (FA) profiles of 28 edible vegetable oils and 40 non-edible vegetable oils were collected. Their main specifications including sulfur content, density, viscosity, flash point, cloud point, pour point, cold filter plugging point, cetane number, iodine number, heating value, acid value and carbon residual before and after transesterification (vegetable oil and biodiesel, respectively) were analyzed in detail. Many researchers have developed prediction models to quantify biodiesel specifications to optimize its manufacturing and obtain biodiesel with the best specifications. Three factors that are especially influential are the fatty acids profiles, the degree of unsaturation within the FA structures and molecular weight. Accordingly, many models have been constructed on these features. There are also models that quantify the relationship between the biodiesel specifications and its thermodynamic properties or other specifications. Accordingly, the second part of this work was conducted on the existing prediction models. All the models were discussed along with their deviation in prediction.

Performance of $b$-Jet Identification in the ATLAS Experiment

Abstract: The identification of jets containing b hadrons is important for the physics programme of the ATLAS experiment at the Large Hadron Collider. Several algorithms to identify jets containing b hadrons are described, ranging from those based on the reconstruction of an inclusive secondary vertex or the presence of tracks with large impact parameters to combined tagging algorithms making use of multi-variate discriminants. An independent b-tagging algorithm based on the reconstruction of muons inside jets as well as the b-tagging algorithm used in the online trigger are also presented. The b-jet tagging efficiency, the c-jet tagging efficiency and the mistag rate for light flavour jets in data have been measured with a number of complementary methods. The calibration results are presented as scale factors defined as the ratio of the efficiency (or mistag rate) in data to that in simulation. In the case of b jets, where more than one calibration method exists, the results from the various analyses have been combined taking into account the statistical correlation as well as the correlation of the sources of systematic uncertainty.