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Showing papers by "University of Malaya published in 2017"


Journal ArticleDOI
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.

10,401 citations


Journal ArticleDOI
Bin Zhou1, James Bentham1, Mariachiara Di Cesare2, Honor Bixby1  +787 moreInstitutions (231)
TL;DR: The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries, and the contributions of changes in prevalence versus population growth and ageing to the increase.

1,573 citations


Journal ArticleDOI
TL;DR: The sources and global distribution of microplastics in the environment, the fate and impact on marine biota, especially the food chain are described and the control measures discussed are those mapped out by both national and international environmental organizations for combating the impact from microplastic pollution.

1,487 citations


Journal ArticleDOI
TL;DR: In this work, a 13-layer deep convolutional neural network (CNN) algorithm is implemented to detect normal, preictal, and seizure classes and achieved an accuracy, specificity, and sensitivity of 88.67%, 90.00% and 95.00%, respectively.

1,117 citations


Journal ArticleDOI
TL;DR: A 9-layer deep convolutional neural network (CNN) is developed to automatically identify 5 different categories of heartbeats in ECG signals to serve as a tool for screening of ECG to quickly identify different types and frequency of arrhythmicheartbeats.

938 citations


Journal ArticleDOI
TL;DR: The economic potential assessment of microalgae biorefinery was evaluated and high-value co-products produced through the extraction of a fraction of algae were evaluated to highlight the feasibility of the process.

910 citations


Journal ArticleDOI
Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1, Ece Aşılar1  +2212 moreInstitutions (157)
TL;DR: A fully-fledged particle-flow reconstruction algorithm tuned to the CMS detector was developed and has been consistently used in physics analyses for the first time at a hadron collider as mentioned in this paper.
Abstract: The CMS apparatus was identified, a few years before the start of the LHC operation at CERN, to feature properties well suited to particle-flow (PF) reconstruction: a highly-segmented tracker, a fine-grained electromagnetic calorimeter, a hermetic hadron calorimeter, a strong magnetic field, and an excellent muon spectrometer. A fully-fledged PF reconstruction algorithm tuned to the CMS detector was therefore developed and has been consistently used in physics analyses for the first time at a hadron collider. For each collision, the comprehensive list of final-state particles identified and reconstructed by the algorithm provides a global event description that leads to unprecedented CMS performance for jet and hadronic τ decay reconstruction, missing transverse momentum determination, and electron and muon identification. This approach also allows particles from pileup interactions to be identified and enables efficient pileup mitigation methods. The data collected by CMS at a centre-of-mass energy of 8\TeV show excellent agreement with the simulation and confirm the superior PF performance at least up to an average of 20 pileup interactions.

719 citations


Journal ArticleDOI
TL;DR: A convolutional neural network algorithm is implemented for the automated detection of a normal and MI ECG beats (with noise and without noise) and can accurately detect the unknown ECG signals even with noise.

645 citations



Journal ArticleDOI
TL;DR: This paper reviews several inertia and frequency control techniques proposed for variable speed wind turbines and solar PV generators and includes inertia emulation, fast power reserve, and droop techniques, which are used to release the RESs reserve power at under frequency events.
Abstract: Preservation of the environment has become the main motivation to integrate more renewable energy sources (RESs) in electrical networks. However, several technical issues are prevalent at high level RES penetration. The most important technical issue is the difficulty in achieving the frequency stability of these new systems, as they contain less generation units that provide reserve power. Moreover, new power systems have small inertia constant due to the decoupling of the RESs from the AC grid using power converters. Therefore, the RESs in normal operation cannot participate with other conventional generation sources in frequency regulation. This paper reviews several inertia and frequency control techniques proposed for variable speed wind turbines and solar PV generators. Generally, the inertia and frequency regulation techniques were divided into two main groups. The first group includes the deloading technique, which allow the RESs to keep a certain amount of reserve power, while the second group includes inertia emulation, fast power reserve, and droop techniques, which is used to release the RESs reserve power at under frequency events.

575 citations


Journal ArticleDOI
TL;DR: A convolutional neural network (CNN) technique to automatically detect the different ECG segments and can serve as an adjunct tool to assist clinicians in confirming their diagnosis is presented.

Journal ArticleDOI
25 Apr 2017-JAMA
TL;DR: Among patients undergoing noncardiac surgery, peak postoperative hsTnT during the first 3 days after surgery was significantly associated with 30-day mortality and potential diagnostic criteria for MINS was found.
Abstract: Importance Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). Objective To determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS (ie, myocardial injury due to ischemia associated with 30-day mortality). Design, Setting, and Participants Prospective cohort study of patients aged 45 years or older who underwent inpatient noncardiac surgery and had a postoperative hsTnT measurement. Starting in October 2008, participants were recruited at 23 centers in 13 countries; follow-up finished in December 2013. Exposures Patients had hsTnT measurements 6 to 12 hours after surgery and daily for 3 days; 40.4% had a preoperative hsTnT measurement. Main Outcomes and Measures A modified Mazumdar approach (an iterative process) was used to determine if there were hsTnT thresholds associated with risk of death and had an adjusted hazard ratio (HR) of 3.0 or higher and a risk of 30-day mortality of 3% or higher. To determine potential diagnostic criteria for MINS, regression analyses ascertained if postoperative hsTnT elevations required an ischemic feature (eg, ischemic symptom or electrocardiography finding) to be associated with 30-day mortality. Results Among 21 842 participants, the mean age was 63.1 (SD, 10.7) years and 49.1% were female. Death within 30 days after surgery occurred in 266 patients (1.2%; 95% CI, 1.1%-1.4%). Multivariable analysis demonstrated that compared with the reference group (peak hsTnT Conclusions and Relevance Among patients undergoing noncardiac surgery, peak postoperative hsTnT during the first 3 days after surgery was significantly associated with 30-day mortality. Elevated postoperative hsTnT without an ischemic feature was also associated with 30-day mortality.

Journal ArticleDOI
TL;DR: In this paper, the trigger system consists of two levels designed to select events of potential physics interest from a GHz (MHz) interaction rate of proton-proton (heavy ion) collisions.
Abstract: This paper describes the CMS trigger system and its performance during Run 1 of the LHC. The trigger system consists of two levels designed to select events of potential physics interest from a GHz (MHz) interaction rate of proton-proton (heavy ion) collisions. The first level of the trigger is implemented in hardware, and selects events containing detector signals consistent with an electron, photon, muon, tau lepton, jet, or missing transverse energy. A programmable menu of up to 128 object-based algorithms is used to select events for subsequent processing. The trigger thresholds are adjusted to the LHC instantaneous luminosity during data taking in order to restrict the output rate to 100 kHz, the upper limit imposed by the CMS readout electronics. The second level, implemented in software, further refines the purity of the output stream, selecting an average rate of 400 Hz for offline event storage. The objectives, strategy and performance of the trigger system during the LHC Run 1 are described.

Journal ArticleDOI
TL;DR: In this paper, the authors present an overview on the first and second generation bioethanol production with a particular attention to the potential of various biomass sources, technological approaches, role of microorganisms and factors affecting ethanol production process.
Abstract: Bioethanol is an attractive biofuel having potential for energy security and environmental safety over fossil fuels. To date, numerous biomass resources have been investigated for bioethanol production, which can broadly be classified into sugars, starch and lignocellulosic biomass. However, conversion of biomass into ethanol varies considerably depending on the nature of feedstock, primarily due to the variation in biochemical composition, and so, only a few feedstocks have been exploited commercially. In recent years, the conversion process of biomass has been improved significantly, even though most of these achievements are yet to be implemented in commercial facility. All the major steps in a typical conversion process, particularly fermentation of sugars that is the common step for all biomass, are greatly influenced by microorganisms. A traditional yeast, Saccharomyces cerevisiae, and a bacterial species, Zymomonas mobilis, are widely used in the ethanol fermentation technology. Many factors affect ethanol production process, and the final yield is directly associated with the optimum conditions of these attributes. This review paper presents an overview on the first and second generation bioethanol production with a particular attention to the potential of various biomass sources, technological approaches, role of microorganisms and factors affecting ethanol production process.

Journal ArticleDOI
Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2285 moreInstitutions (147)
TL;DR: In this paper, an improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented.
Abstract: Improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented. The corrections as a function of pseudorapidity η and transverse momentum p_T are extracted from data and simulated events combining several channels and methods. They account successively for the effects of pileup, uniformity of the detector response, and residual data-simulation jet energy scale differences. Further corrections, depending on the jet flavor and distance parameter (jet size) R, are also presented. The jet energy resolution is measured in data and simulated events and is studied as a function of pileup, jet size, and jet flavor. Typical jet energy resolutions at the central rapidities are 15–20% at 30 GeV, about 10% at 100 GeV, and 5% at 1 TeV. The studies exploit events with dijet topology, as well as photon+jet, Z+jet and multijet events. Several new techniques are used to account for the various sources of jet energy scale corrections, and a full set of uncertainties, and their correlations, are provided. The final uncertainties on the jet energy scale are below 3% across the phase space considered by most analyses (p_T > 30 GeV and 0|η| 30 GeV is reached, when excluding the jet flavor uncertainties, which are provided separately for different jet flavors. A new benchmark for jet energy scale determination at hadron colliders is achieved with 0.32% uncertainty for jets with p_T of the order of 165–330 GeV, and |η| < 0.8.

Journal ArticleDOI
TL;DR: In this article, the authors provide a comprehensive survey of state-of-the-art remote sensing deep learning research for remote sensing applications, focusing on theories, tools, and challenges for the remote sensing community.
Abstract: In recent years, deep learning (DL), a rebranding of neural networks (NNs), has risen to the top in numerous areas, namely computer vision (CV), speech recognition, and natural language processing. Whereas remote sensing (RS) possesses a number of unique challenges, primarily related to sensors and applications, inevitably RS draws from many of the same theories as CV, e.g., statistics, fusion, and machine learning, to name a few. This means that the RS community should not only be aware of advancements such as DL, but also be leading researchers in this area. Herein, we provide the most comprehensive survey of state-of-the-art RS DL research. We also review recent new developments in the DL field that can be used in DL for RS. Namely, we focus on theories, tools, and challenges for the RS community. Specifically, we focus on unsolved challenges and opportunities as they relate to (i) inadequate data sets, (ii) human-understandable solutions for modeling physical phenomena, (iii) big data, (iv) nontraditional heterogeneous data sources, (v) DL architectures and learning algorithms for spectral, spatial, and temporal data, (vi) transfer learning, (vii) an improved theoretical understanding of DL systems, (viii) high barriers to entry, and (ix) training and optimizing the DL.

Journal ArticleDOI
TL;DR: A taxonomy is devised to best bring forth a generic overview of the IoT paradigm for smart cities, integrated ICT, network types, possible opportunities and major requirements, and the latest synergies and initiatives worldwide taken to promote IoT in the context of smart cities.
Abstract: The Internet of Things is a novel cutting edge technology that proffers to connect a plethora of digital devices endowed with several sensing, actuation, and computing capabilities with the Internet, thus offering manifold new services in the context of a smart city. The appealing IoT services and big data analytics are enabling smart city initiatives all over the world. These services are transforming cities by improving infrastructure and transportation systems, reducing traffic congestion, providing waste management, and improving the quality of human life. In this article, we devise a taxonomy to best bring forth a generic overview of the IoT paradigm for smart cities, integrated ICT, network types, possible opportunities and major requirements. Moreover, an overview of the up-to-date efforts from standard bodies is presented. Later, we give an overview of existing open source IoT platforms for realizing smart city applications followed by several exemplary case studies. In addition, we summarize the latest synergies and initiatives worldwide taken to promote IoT in the context of smart cities. Finally, we highlight several challenges in order to give future research directions.

Journal ArticleDOI
TL;DR: This paper aims at providing a deep insight into advanced oxidation processes, photocatalysts and their applications in wastewater treatment, doping processes and the effects of operational factors on photoc atalytic degradation.

Journal ArticleDOI
TL;DR: The principle of thermal insulation is by the proper installation of insulation using energy-efficient materials that would reduce the heat loss or heat gain, which leads to reduction of energy cost as the result as mentioned in this paper.
Abstract: In residential sector, air conditioning system takes the biggest portion of overall energy consumption to fulfil the thermal comfort need. In addressing the issue, thermal insulation is one efficient technology to utilize the energy in providing the desired thermal comfort by its environmentally friendly characteristics. The principle of thermal insulation is by the proper installation of insulation using energy-efficient materials that would reduce the heat loss or heat gain, which leads to reduction of energy cost as the result. This paper is aimed to gather most recent developments on the building thermal insulations and also to discuss about the life-cycle analysis and potential emissions reduction by using proper insulation materials.

Journal ArticleDOI
TL;DR: The reality of BIM, its widespread benefits and current level of uptake are discussed, as well as recommendations regarding how future BIM adoption could be developed are also highlighted.
Abstract: Rapid advancement of technology continues to leverage change and innovation in the construction industry. Continued digitization of the industry offers the opportunity to totally reinvent contemporary construction design and delivery practice for future development. Building Information Modelling (BIM) within the context of Architecture, Engineering & Construction (AEC) has been developing since the early 2000s and is considered to be a key technology. Despite major technical advancements in BIM, it has not been fully adopted and its definitive benefits have not been fully capitalized upon by industry stakeholders. The lack of widespread uptake of BIM appears to be linked to the risks and challenges that are potentially impeding its effectiveness. This paper aims to discuss the reality of BIM, its widespread benefits and current level of uptake. The risks and challenges associated with the adoption of BIM, as well as recommendations regarding how future BIM adoption could be developed are also highlighted.

Journal ArticleDOI
12 Apr 2017-Polymers
TL;DR: The role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract is enlightened.
Abstract: Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pKa and pKb values on the ionization, consequent swelling, and targeted drug release are also highlighted.

Journal ArticleDOI
TL;DR: In this paper, a comprehensive evaluation on the magnetic hyperthermia therapy through the determination of magnetic nanoparticles such as surface chemistry, intrinsic and extrinsic magnetic properties are reviewed.

Proceedings ArticleDOI
01 Nov 2017
TL;DR: The Total-Text dataset as discussed by the authors is a large scale scene text dataset with a large number of curve-oriented text orientations, including horizontal and multioriented text, and features curved text.
Abstract: Text in curve orientation, despite being one of the common text orientations in real world environment, has close to zero existence in well received scene text datasets such as ICDAR'13 and MSRA-TD500. The main motivation of Total-Text is to fill this gap and facilitate a new research direction for the scene text community. On top of conventional horizontal and multi-oriented text, it features curved-oriented text. Total-Text is highly diversified in orientations, more than half of its images have a combination of more than two orientations. Recently, a new breed of solutions that casted text detection as a segmentation problem has demonstrated their effectiveness against multi-oriented text. In order to evaluate its robustness against curved text, we fine-tuned DeconvNet and benchmark it on Total-Text. Total-Text with its annotation is available at https://github.com/cs-chan/Total-Text-Dataset.

Journal ArticleDOI
TL;DR: The recommendations provided herein are intended for use by healthcare providers in their management of older adults with frailty in the Asia Pacific region and it is proposed that regional guideline support committees be formed to help provide regular updates to these evidence-based guidelines.

Journal ArticleDOI
TL;DR: A systematic review of the development of green rating systems is presented in this article, where the authors identify the similarity, difference, strength and weakness of green ratings, and examine whether they fully assess the projects in all aspects of sustainability.

Journal ArticleDOI
Morad Aaboud, Alexander Kupco1, Peter Davison2, Samuel Webb3  +2944 moreInstitutions (220)
TL;DR: In this article, a search for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states was conducted using 36 : 1 fb(-1) of proton-proton collision data.
Abstract: A search is conducted for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states. The search uses 36 : 1 fb(-1) of proton-proton collision data, collected at root ...

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the influence of operating parameters on solid fuel production during Hydrothermal carbonization (HTC) by extending existing literature work through experiments that have been performed.
Abstract: The preceding decades witnessed hydrothermal processes being actively utilized all over the world, specifically in the developed zones. Their optimum usage is primarily sought for in terms of conversion of biomass into valuable solid, liquid and gaseous fuels. Indeed, Hydrothermal carbonization (HTC) is an effective and environment friendly technique; it possesses extensive potential towards producing high-energy density solid fuels. However, the production and quality of solid fuels from HTC depends upon several parameters; temperature, feed type, residence time, pressure and catalyst being the eminent ones. This study investigates the influence of operating parameters on solid fuel production during HTC. The biomass quality has also been analyzed in HTC by extending existing literature work through experiments that have been performed. Data including chemical composition, heating value, proximate analysis and ultimate analysis for different types of biomass was consequently collected and analyzed. It was found that reaction temperature, residence time and type of feed material are the primary factors that influence the HTC process. At higher temperatures, lower solid product is obtained; the carbon content increases, whilst the hydrogen and oxygen content decrease. Further, it has been found that higher lignin content in biomass leads to an increased solid fuel production.

Journal ArticleDOI
TL;DR: The aim of this review was to introduce conventional and recently-developed extraction techniques, with emphasis on the use of DESs as potential extractants for various bioactive compounds, such as phenolic acid, flavonoids, tanshinone, keratin, tocols, terpenoids, carrageenans, xanthones, isoflavones, α-mangostin, genistin, apigenin, and others.

Journal ArticleDOI
TL;DR: The purpose of this review was to present the current status of the knowledge and understanding of the involvement of mitochondrial dysfunction in pathogenesis of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) and the importance of mitochondrial biogenesis as a potential novel therapeutic target for their treatment.
Abstract: Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and characterized by the progressive degeneration of the function and structure of the central nervous system (CNS) for reasons that are not yet understood. Neurodegeneration is the umbrella term for the progressive death of nerve cells and loss of brain tissue. Because of their high energy requirements, neurons are especially vulnerable to injury and death from dysfunctional mitochondria. Widespread damage to mitochondria causes cells to die because they can no longer produce enough energy. Several lines of pathological and physiological evidence reveal that impaired mitochondrial function and dynamics play crucial roles in aging and pathogenesis of neurodegenerative diseases. As mitochondria are the major intracellular organelles that regulate both cell survival and death, they are highly considered as a potential target for pharmacological-based therapies. The purpose of this review was to present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the importance of mitochondrial biogenesis as a potential novel therapeutic target for their treatment. Likewise, we highlight a concise overview of the key roles of mitochondrial electron transport chain (ETC.) complexes as well as mitochondrial biogenesis regulators regarding those diseases.

Journal ArticleDOI
TL;DR: In this article, a review of the characteristics of the heterogeneous catalysts (solid base, solid acid, acid base, acid-base and bio-catalyst) is presented.
Abstract: The research on biodiesel production via heterogeneous catalyzed approach is continuously studied by scientist in order to gain a sustainable process for industrial production and to improve its fuel quality The green resource of biodiesel feedstock and catalyst is the major criteria to influence the biodiesel yield and sustainability of the process For the state of the art biodiesel production technology, heterogeneous catalyst received great attention for simple and low cost manufacturing process In terms of easy separation and high reusability The most special characteristic of heterogeneous catalyst is its tuning properties that generate acidic-basicity, surface area and porosity that can highly advance the variety of the feedstock for esterification/transesterification process Different traits of the heterogeneous catalysts (solid base, solid acid, acid-base and bio-catalyst) are studied in this review as each holds a specialty of features to the process Thus, the study of heterogeneous catalyst should continue to be evaluated and taken into account if the catalyst are to be employed in the commercial sector as that remains the pivotal goal of these studies In consideration to the debate of food vs fuel as well as low cost production, non-edible feedstock was further discussed by using heterogeneous catalyzed system