University of Malaya

About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.

Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease.

Abstract: Noncoding repeat expansions cause various neuromuscular diseases, including myotonic dystrophies, fragile X tremor/ataxia syndrome, some spinocerebellar ataxias, amyotrophic lateral sclerosis and benign adult familial myoclonic epilepsies. Inspired by the striking similarities in the clinical and neuroimaging findings between neuronal intranuclear inclusion disease (NIID) and fragile X tremor/ataxia syndrome caused by noncoding CGG repeat expansions in FMR1, we directly searched for repeat expansion mutations and identified noncoding CGG repeat expansions in NBPF19 (NOTCH2NLC) as the causative mutations for NIID. Further prompted by the similarities in the clinical and neuroimaging findings with NIID, we identified similar noncoding CGG repeat expansions in two other diseases: oculopharyngeal myopathy with leukoencephalopathy and oculopharyngodistal myopathy, in LOC642361/NUTM2B-AS1 and LRP12, respectively. These findings expand our knowledge of the clinical spectra of diseases caused by expansions of the same repeat motif, and further highlight how directly searching for expanded repeats can help identify mutations underlying diseases.

Wireless Powering by Magnetic Resonant Coupling: Recent Trends in Wireless Power Transfer System and its Applications

Abstract: Wireless power transfer (WPT) concept offers users the freedom from annoying wires, and allowing seamless powering and charging of portable devices in an unburdened mode. Since Nikola Tesla׳s early experiment, the WPT technology has observed the remarkable technological advancement on transmission methods which previously deemed unfeasible. This review paper outlines recent research activities on wireless power technology covering the history, the basic principle of magnetic resonant coupling, and early works on resonant coupled WPT. The two fundamental concepts of power transmission, the maximum power transfer and maximum energy efficiency principles, are summarized in terms of their energy efficiency and transmission distance capabilities. This paper also reviews the comparative study between coupled-mode theory (CMT) and reflected load theory (RLT) in case of analyzing the power transmission model of conventional 2-coil resonant coupled WPT with frequency splitting modes. The study shows that circuit-based RLT provides accurate results as CMT while predicting the average power transmission efficiency in steady-state analysis and is more convenient. This paper explains the effectiveness of advance 4-coil resonant coupled system adopting maximum power transfer principle in extending the operating range of WPT with better power transmission. Various efficiency enhancement techniques for resonant coupled WPT including system with multiple receivers are demonstrated in this paper. The review implies that the adaptive impedance matching using LC circuits is more prolific in practical terms to improve the efficiency of coupled coils. Moreover, the benefits of resonant coupled WPT, its implementation in both consumer and non-consumer applications, and the commercial journey of WPT along with the safety consideration to human exposure issues are also addressed in this paper.

Green Gas to Replace SF6 in Electrical Grids

Abstract: Environmental considerations are increasingly taking a front seat in all arenas of our daily livesmpolitical, industrial and societal. Not least among the major concerns are global warming and the greenhouse gases that contribute to it, as their concentration in the air reaches new heights. Hence the power industryas focus on sulfur hexafluoride (SF6) and the need to find a suitable alternative for it in industrial applications. Grid Solutions, a GE and Alstom joint venture, has identified a fluoronitrile based gas mixture dubbed lg3ngreen gas for gridr that is such a alternative.

Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis

Abstract: Purpose This study aims to determine if continuous infusion (CI) is associated with better clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent bolus (IB) dosing in critically ill patients with severe sepsis.