Institution
University of Malaya
Education•Kuala Lumpur, Malaysia•
About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.
Topics: Population, Fiber laser, Laser, Ring (chemistry), Catalysis
Papers published on a yearly basis
Papers
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TL;DR: A literature review of the effect of various additives on biodiesel properties, engine performance and exhaust emission characteristics and the corresponding effect factors were surveyed and analyzed in detail as mentioned in this paper, concluding that the use of additive in biodiesel fuel is inalienable both for improving properties and for better engine performance.
192 citations
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TL;DR: It seems that c-Kit mutations alone are not sufficient for tumorogenesis, but do play a crucial role in cancer occurrence, and it is unlikely that Kit inhibitors alone can lead to cure.
Abstract: c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the concept that inhibiting c-Kit kinase activity can be a target for cancer therapy. The promising results of inhibition of c-Kit for treatment of cancers have been observed in some cancers such as gastrointestinal stromal tumor, acute myeloid leukemia, melanoma, and other tumors, and these results have encouraged attempts toward improvement of using c-Kit as a capable target for cancer therapy. This paper presents the findings of previous studies regarding c-Kit as a receptor tyrosine kinase and an oncogene, as well as its gene targets and signaling pathways in normal and cancer cells. The c-Kit gene location, protein structure, and the role of c-Kit in normal cell have been discussed. Comprehending the molecular mechanism underlying c-Kit-mediated tumorogenesis is consequently essential and may lead to the identification of future novel drug targets. The potential mechanisms by which c-Kit induces cellular transformation have been described. This study aims to elucidate the function of c-Kit for future cancer therapy. In addition, it has c-Kit inhibitor drug properties and their functions have been listed in tables and demonstrated in schematic pictures. This review also has collected previous studies that targeted c-Kit as a novel strategy for cancer therapy. This paper further emphasizes the advantages of this approach, as well as the limitations that must be addressed in the future. Finally, although c-Kit is an attractive target for cancer therapy, based on the outcomes of treatment of patients with c-Kit inhibitors, it is unlikely that Kit inhibitors alone can lead to cure. It seems that c-Kit mutations alone are not sufficient for tumorogenesis, but do play a crucial role in cancer occurrence.
192 citations
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Stellenbosch University1, Instituto Superior de Agronomia2, National and Kapodistrian University of Athens3, University of Malaya4, Sapienza University of Rome5, University of California, Davis6, Jerusalem Institute for Israel Studies7, ETH Zurich8, Monash University9, University of Cape Town10, United States Geological Survey11, University of Coimbra12, Escola Superior Agrária de Coimbra13, University of Melbourne14, Royal Botanic Gardens15, CABI16, University of Tennessee17
TL;DR: Global efforts to minimize the risk and limit the impact of invasions in this widely used plant group are reviewed.
Abstract: Aim Many Australian Acacia species have been planted around the world, some are highly valued, some are invasive, and some are both highly valued and invasive. We review global efforts to minimize the risk and limit the impact of invasions in this widely used plant group.
192 citations
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International AIDS Society1, University of Cape Town2, Pan American Health Organization3, Johns Hopkins University4, University of California, San Diego5, New York City Department of Health and Mental Hygiene6, Georgetown University7, United Nations Development Programme8, Bill & Melinda Gates Foundation9, College of Health Sciences, Bahrain10, University of California, San Francisco11, University of Malaya12, Graduate Institute of International and Development Studies13, McGill University Health Centre14, University of Melbourne15, UNICEF16, Harvard University17, University of London18, University Hospital Bonn19, Aix-Marseille University20, World Health Organization21, Guttmacher Institute22, Istituto Superiore di Sanità23, Federal University of Rio de Janeiro24, University of Bristol25
TL;DR: Author(s): Bekker, Linda-Gail; Alleyne, George; Baral, Stefan; Cepeda, Javier; Daskalakis, Demetre; Dowdy, David; Kilonzo, Nduku; Klag, Michael; Klein, Marina; Lewin, Sharon R; Stars, Ann; Strathdee, Steffanie A; Thomson, Nicholas; Schechter, Mauro; Vickerman, Peter; Weir, Brian
192 citations
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TL;DR: In this paper, the authors consider the role of the formal leader within distributed leadership and outline some of the challenges and tensions associated with distributed leadership practice and highlight what we know about the relationship between formal leadership and organizational performance.
Abstract: Distributed leadership is now widely known and variously enacted in schools and school systems. Distributed leadership implies a fundamental re-conceptualisation of leadership as practice and challenges conventional wisdom about the relationship between formal leadership and organisational performance. There has been much debate, speculation and discussion about its positive and negative aspects. This article considers the evidence. It examines the facts concerning distributed leadership. It does not claim to be a systematic review of the literature but rather draws upon the available empirical evidence to highlight what we know. The article considers the implications, arising from the evidence for those in formal leadership positions. It concludes by reflecting upon the role of the formal leader within distributed leadership and outlines some of the challenges and tensions associated with distributed leadership practice.
192 citations
Authors
Showing all 25327 results
Name | H-index | Papers | Citations |
---|---|---|---|
Diederick E. Grobbee | 155 | 1051 | 122748 |
Intae Yu | 134 | 1372 | 89870 |
Ovsat Abdinov | 129 | 864 | 78489 |
Jyothsna Rani Komaragiri | 129 | 1097 | 82258 |
Odette Benary | 128 | 844 | 74238 |
Paul M. Vanhoutte | 127 | 868 | 62177 |
Irene Vichou | 126 | 762 | 72520 |
Ian O. Ellis | 126 | 1051 | 75435 |
Louisa Degenhardt | 126 | 798 | 139683 |
Matthew Jones | 125 | 1161 | 96909 |
Andrius Juodagalvis | 118 | 1069 | 67138 |
Martin Ravallion | 115 | 570 | 55380 |
R. St. Denis | 112 | 921 | 65326 |
Xiao-Ming Chen | 108 | 596 | 42229 |
A. Yurkewicz | 106 | 514 | 51537 |