University of Malaya

About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.

In Vitro and In Vivo toxicity profiling of ammonium-based deep eutectic solvents.

Abstract: The cytotoxic potential of ammonium-based deep eutectic solvents (DESs) with four hydrogen bond donors, namely glycerine (Gl), ethylene glycol (EG), triethylene glycol (TEG) and urea (U) were investigated. The toxicity of DESs was examined using In Vitro cell lines and In Vivo animal model. IC50 and selectivity index were determined for the DESs, their individual components and their combinations as aqueous solutions for comparison purposes. The cytotoxicity effect of DESs varied depending on cell lines. The IC50 for the GlDES, EGDES, UDES and TEGDES followed the sequence of TEGDES< GlDES< EGDES< UDES for OKF6, MCF-7, A375, HT29 and H413, respectively. GlDES was selective against MCF-7 and A375, EGDES was selective against MCF-7, PC3, HepG2 and HT29, UDES was selective against MCF-7, PC3, HepG2 and HT29, and TEGDES was selective against MCF-7 and A375. However, acute toxicity studies using ICR mice showed that these DESs were relatively toxic in comparison to their individual components. DES did not cause DNA damage, but it could enhance ROS production and induce apoptosis in treated cancer cells as evidenced by marked LDH release. Furthermore, the examined DESs showed less cytotoxicity compared with ionic liquids. To the best of our knowledge, this is the first time that combined In Vitro and In Vivo toxicity profiles of DESs were being demonstrated, raising the toxicity issue of these neoteric mixtures and their potential applicability to be used for therapeutic purposes.

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.

Abstract: Colorectal cancer (CRC) remains the third most common cancer worldwide, with a growing incidence among young adults. Multiple studies have presented associations between the gut microbiome and CRC, suggesting a link with cancer risk. Although CRC microbiome studies continue to profile larger patient cohorts with increasingly economical and rapid DNA sequencing platforms, few common associations with CRC have been identified, in part due to limitations in taxonomic resolution and differences in analysis methodologies. Complementing these taxonomic studies is the newly recognized phenomenon that bacterial organization into biofilm structures in the mucus layer of the gut is a consistent feature of right-sided (proximal), but not left-sided (distal) colorectal cancer. In the present study, we performed 16S rRNA gene amplicon sequencing and biofilm quantification in a new cohort of patients from Malaysia, followed by a meta-analysis of eleven additional publicly available data sets on stool and tissue-based CRC microbiota using Resphera Insight, a high-resolution analytical tool for species-level characterization. Results from the Malaysian cohort and the expanded meta-analysis confirm that CRC tissues are enriched for invasive biofilms (particularly on right-sided tumors), a symbiont with capacity for tumorigenesis (Bacteroides fragilis), and oral pathogens including Fusobacterium nucleatum, Parvimonas micra, and Peptostreptococcus stomatis. Considered in aggregate, species from the Human Oral Microbiome Database are highly enriched in CRC. Although no detected microbial feature was universally present, their substantial overlap and combined prevalence supports a role for the gut microbiota in a significant percentage (>80%) of CRC cases.

Decentralized Consensus for Edge-Centric Internet of Things: A Review, Taxonomy, and Research Issues

Abstract: With the exponential rise in the number of devices, the Internet of Things (IoT) is geared toward edge-centric computing to offer high bandwidth, low latency, and improved connectivity. In contrast, legacy cloud-centric platforms offer deteriorated bandwidth and connectivity that affect the quality of service. Edge-centric Internet of Things-based technologies, such as fog and mist computing, offer distributed and decentralized solutions to resolve the drawbacks of cloud-centric models. However, to foster distributed edge-centric models, a decentralized consensus system is necessary to incentivize all participants to share their edge resources. This paper is motivated by the shortage of comprehensive reviews on decentralized consensus systems for edge-centric Internet of Things that elucidates myriad of consensus facets, such as data structure, scalable consensus ledgers, and transaction models. Decentralized consensus systems adopt either blockchain or blockchainless directed acyclic graph technologies, which serve as immutable public ledgers for transactions. This paper scrutinizes the pros and cons of state-of-the-art decentralized consensus systems. With an extensive literature review and categorization based on existing decentralized consensus systems, we propose a thematic taxonomy. The pivotal features and characteristics associated with existing decentralized consensus systems are analyzed via a comprehensive qualitative investigation. The commonalities and variances among these systems are analyzed using key criteria derived from the presented literature. Finally, several open research issues on decentralized consensus for edge-centric IoT are presented, which should be highlighted regarding centralization risk and deficiencies in blockchain/blockchainless solutions.

Searches for Higgs boson pair production in the hh →bbττ, γγWW∗, γγbb, bbbb channels with the ATLAS detector

Abstract: Searches for both resonant and nonresonant Higgs boson pair production are performed in the hh -> bb tau tau, gamma gamma WW* final states using 20.3 fb(-1) of pp collision data at a center-of-m ...