University of Malaya

About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.

Direct characterization of Blastocystis from faeces by PCR and evidence of zoonotic potential.

Abstract: In vitro propagation followed by PCR, and a PCR-based method capable of the direct detection of Blastocystis in faeces were utilized to detect Blastocystis from various hosts in Australia, including primates and their handlers from the Perth Zoo. In addition, Blastocystis isolates from dogs and humans living in a localized endemic community in Thailand were also characterized genetically. PCR-based detection directly from faeces was shown to be more sensitive compared with in vitro culture for the detection of Blastocystis. Moreover, phylogenetic analysis of Blastocystis isolates amplified utilizing in vitro techniques prior to PCR revealed that this method favoured the preferential amplification of Blastocystis subtype 5 over subtype 1. This study is the first to provide molecular-based evidence supporting the zoonotic potential of Blastocystis in dogs, possums and primates in a natural setting.

Social Representations of Events and People in World History Across 12 Cultures

Abstract: Social representations of world history were assessed using the open-ended questions, “What are the most important events in world history?” and “Who are the most influential persons in world history in the last 1000 years?” Data from 6 Asian and 6 Western samples showed cross-cultural consensus. Historical representations were (a) focused on the recent past, (b) centered around politics and war, and (c) dominated by the events of the World Wars and (d) the individual Hitler, who was universally perceived as negative. (e) Representations were more Eurocentric than ethnocentric. (f) The importance of economics and science was underrepresented. (g) Most cultures nominated people (more than events) idiosyncratic to their own culture. These data reflect power relations in the world and provide resources and constraints for the conduct of international relations. The degree of cross-cultural consensus suggests that hybridity across Eastern and Western cultures in the representation of knowledge may be underestimated.

Systematic review of qualitative studies exploring parental experiences in the Neonatal Intensive Care Unit.

Abstract: Aims and objectives To determine the feasibility and utility of a thematic analysis approach to synthesising qualitative evidence about parental experiences in the neonatal intensive care unit. Background Admission of infants to the neonatal intensive care unit is usually an unexpected event for parents who can cause them to experience psychosocial difficulties. A qualitative systematic review is the best method for exploring these parents’ experiences regarding this type of admission. Design Systematic review. Methods Qualitative studies in peer-reviewed journals aimed at understanding parental experiences regarding infant neonatal intensive care unit admission were identified in six electronic databases. Three reviewers selected relevant articles and assessed the quality of the methodological studies using the Critical Appraisal Skills Programme. A thematic analysis approach was used to identify the most common themes in the studies describing parental experiences in the neonatal intensive care unit. Results A total of eighty articles were identified; nine studies were included in this review. Four studies used semistructured interviews, three used interviews, one used self-reporting and one used both focus group and interview methodologies. Common themes across parents’ experiences were the stress of hospitalisation, alteration in parenting roles and the impact of infant hospitalisation on psychological health. Conclusion Having an infant hospitalised in the neonatal intensive care unit is a stressful experience for parents. This experience is the result of exposure to different stressors related to the infant's condition, an alteration in parenting roles or the neonatal intensive care unit environment and staffing. These parents suffered negative psychological effects, experienced an interrupted development of a healthy parent–infant attachment and/or felt parental role alteration. Relevance to clinical practice The study's findings are crucial for neonatal intensive care unit nurses to develop intervention strategies and programmes that help parents to decrease the stress of their experience and to support them in facing this stressful situation.

The Microbiome and Irritable Bowel Syndrome - A Review on the Pathophysiology, Current Research and Future Therapy

Abstract: Irritable bowel syndrome (IBS) is a functional disorder which affects a large proportion of the population globally. The precise etiology of IBS is still unknown, although consensus understanding proposes IBS to be of multifactorial origin with yet undefined subtypes. Genetic and epigenetic factors, stress-related nervous and endocrine systems, immune dysregulation and the brain-gut axis seem to be contributing factors that predispose individuals to IBS. In addition to food hypersensitivity, toxins and adverse life events, chronic infections and dysbiotic gut microbiota have been suggested to trigger IBS symptoms in tandem with the predisposing factors. This review will summarize the pathophysiology of IBS and the role of gut microbiota in relation to IBS. Current methodologies for microbiome studies in IBS such as genome sequencing, metagenomics, culturomics and animal models will be discussed. The myriad of therapy options such as immunoglobulins (immune-based therapy), probiotics and prebiotics, dietary modifications including FODMAP restriction diet and gluten-free diet, as well as fecal transplantation will be reviewed. Finally this review will highlight future directions in IBS therapy research, including identification of new molecular targets, application of 3-D gut model, gut-on-a-chip and personalized therapy.