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Institution

University of Malaya

EducationKuala Lumpur, Malaysia
About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.


Papers
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Journal ArticleDOI
TL;DR: No mutation was found in any of the acromegaly and small FIHP families, suggesting that genetic defects other than the MEN1 gene might be involved and that additional such families need to be analyzed.
Abstract: Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disease characterized by neoplasia of the parathyroid glands, the endocrine pancreas, and the anterior pituitary gland. In addition, families with isolated endocrine neoplasia, notably familial isolated hyperparathyroidism (FIHP) and familial acromegaly, have also been reported. However, whether these families constitute MEN 1 variants or separate entities remains speculative as the genetic bases for these diseases are unclear. The gene for MEN 1 has recently been cloned and characterized. Using single strand conformation analysis (SSCA) and sequencing, we performed mutation analysis in: a) a total of 55 MEN 1 families from 7 countries, b) 13 isolated MEN 1 cases without family history of the disease, c) 8 acromegaly families, and d) 4 FIHP families. Mutations were identified in 27 MEN 1 families and 9 isolated cases. The 22 different mutations spread across most of the 9 translated exons and included frameshift (11), nonsense (6), splice (2), missense mutations (2), and in-frame deletions (1). Among the 19 Finnish MEN 1 probands, a 1466del12 mutation was identified in 6 families with identical 11q13 haplotypes and in 2 isolated cases indicating a common founder. One frameshift mutation caused by 359del4 (GTCT) was found in 1 isolated case and 4 kindreds of different origin and haplotypes; this mutation therefore represents a common "warm" spot in the MEN1 gene. By analyzing the DNA of the parents of an isolated case one mutation was confirmed to be de novo. No mutation was found in any of the acromegaly and small FIHP families, suggesting that genetic defects other than the MEN1 gene might be involved and that additional such families need to be analyzed.

180 citations

Journal ArticleDOI
TL;DR: The negative effect of elaidic acid on the lipoprotein profile of humans appears to be unmatched by any other natural fatty acid(s).
Abstract: Although dietary trans fatty acids can affect plasma lipoproteins negatively in humans, no direct comparison with specific saturated fatty acids has been reported, even though trans fatty acids were designed to replace saturates in foods and food processing. In this study, dietary trans 18:1 [elaidic acid at 5.5% energy (en)] was specifically exchanged for cis 18:1, 16:0 or 12:0 + 14:0 in 27 male and female subjects consuming moderate fat (31% en), low cholesterol (<225 mg/d) whole food diets during 4-wk diet periods in a crossover design. The trans-rich fat significantly elevated total cholesterol and LDL cholesterol relative to the 16:0-rich and 18:1-rich fats and uniquely depressed HDL cholesterol relative to all of the fats tested. Trans fatty acids also elevated lipoprotein (a) [Lp(a)] values relative to all dietary treatments. Furthermore, identical effects on lipoproteins were elicited by 16:0 and cis 18:1 in these subjects. The current results suggest that elaidic acid, one of the principal trans isomers produced during industrial hydrogenation of edible oils, adversely affects plasma lipoproteins. Thus, the negative effect of elaidic acid on the lipoprotein profile of humans appears to be unmatched by any other natural fatty acid(s).

180 citations

Journal ArticleDOI
TL;DR: Author(s): Calisher, Charles; Carroll, Dennis; Colwell, Rita; Corley, Ronald B; Drosten, Christian; Enjuanes, Luis; Farrar, Jeremy; Field, Hume; Golding, Josie; Gorbalenya, Alexander; Haagmans, Bart; Hughes, James M; Karesh, William B; Keusch, Gerald T; Lam, Sai Kit; Lubroth, Juan; Mackenzie, John S.

180 citations

Journal ArticleDOI
TL;DR: In this paper, a comprehensive literature review has been carried out on exergy analysis of various solar energy systems, including photovoltaic, solar heating devices, solar water desalination system, solar air conditioning and refrigerators, solar drying process and solar power generation.
Abstract: Solar energy is a clean, abundant and easily available renewable energy. Usage of solar energy in different kinds of systems provides scope for several studies on exergy analysis. In the present work, a comprehensive literature review has been carried out on exergy analysis of various solar energy systems. The systems considered under study are solar photovoltaic, solar heating devices, solar water desalination system, solar air conditioning and refrigerators, solar drying process and solar power generation. The summary of exergy analysis and exergetic efficiencies is presented along with the exergy destruction sources.

180 citations

Journal ArticleDOI
Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1, Federico Ambrogi1  +2319 moreInstitutions (159)
TL;DR: In this article, the performance of missing transverse momentum (Tmiss) reconstruction algorithms for the CMS experiment is presented, using proton-proton collisions at a center of mass energy of 13 TeV, collected at the CERN LHC in 2016.
Abstract: The performance of missing transverse momentum (Tmiss) reconstruction algorithms for the CMS experiment is presented, using proton-proton collisions at a center-of-mass energy of 13 TeV, collected at the CERN LHC in 2016. The data sample corresponds to an integrated luminosity of 35.9 fb-1. The results include measurements of the scale and resolution of Tmiss, and detailed studies of events identified with anomalous Tmiss. The performance is presented of a Tmiss reconstruction algorithm that mitigates the effects of multiple proton-proton interactions, using the "pileup per particle identification" method. The performance is shown of an algorithm used to estimate the compatibility of the reconstructed Tmiss with the hypothesis that it originates from resolution effects.

180 citations


Authors

Showing all 25327 results

NameH-indexPapersCitations
Diederick E. Grobbee1551051122748
Intae Yu134137289870
Ovsat Abdinov12986478489
Jyothsna Rani Komaragiri129109782258
Odette Benary12884474238
Paul M. Vanhoutte12786862177
Irene Vichou12676272520
Ian O. Ellis126105175435
Louisa Degenhardt126798139683
Matthew Jones125116196909
Andrius Juodagalvis118106967138
Martin Ravallion11557055380
R. St. Denis11292165326
Xiao-Ming Chen10859642229
A. Yurkewicz10651451537
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022418
20213,698
20203,646
20193,239
20183,203