Institution
University of Malaya
Education•Kuala Lumpur, Malaysia•
About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.
Topics: Population, Fiber laser, Laser, Ring (chemistry), Electrolyte
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that biallelic PALB2 mutations cause a new subtype of Fanconi anemia, FA-N, and, similar to bIALlelic BRCA2 mutations, confer a high risk of childhood cancer.
Abstract: PALB2 was recently identified as a nuclear binding partner of BRCA2. Biallelic BRCA2 mutations cause Fanconi anemia subtype FA-D1 and predispose to childhood malignancies. We identified pathogenic mutations in PALB2 (also known as FANCN) in seven families affected with Fanconi anemia and cancer in early childhood, demonstrating that biallelic PALB2 mutations cause a new subtype of Fanconi anemia, FA-N, and, similar to biallelic BRCA2 mutations, confer a high risk of childhood cancer.
609 citations
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University of Washington1, University of Southern California2, University of Michigan3, Harvard University4, Max Planck Society5, University of Groningen6, University of Maryland, Baltimore7, Icahn School of Medicine at Mount Sinai8, Xi'an Jiaotong University9, University of Texas MD Anderson Cancer Center10, University of North Carolina at Charlotte11, Broad Institute12, European Bioinformatics Institute13, Yale University14, University of California, Davis15, University of Utah16, Pacific Biosciences17, University of California, San Diego18, Illumina19, Ludwig Institute for Cancer Research20, Ewha Womans University21, Drexel University22, University of Texas Health Science Center at Houston23, Washington University in St. Louis24, University of Malaya25, University of California, San Francisco26, University of British Columbia27, BC Cancer Agency28
TL;DR: A suite of long-read, short- read, strand-specific sequencing technologies, optical mapping, and variant discovery algorithms are applied to comprehensively analyze three trios to define the full spectrum of human genetic variation in a haplotype-resolved manner.
Abstract: The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies of human genetic diversity and disease association. Here, we apply a suite of long-read, short-read, strand-specific sequencing technologies, optical mapping, and variant discovery algorithms to comprehensively analyze three trios to define the full spectrum of human genetic variation in a haplotype-resolved manner. We identify 818,054 indel variants (<50 bp) and 27,622 SVs (≥50 bp) per genome. We also discover 156 inversions per genome and 58 of the inversions intersect with the critical regions of recurrent microdeletion and microduplication syndromes. Taken together, our SV callsets represent a three to sevenfold increase in SV detection compared to most standard high-throughput sequencing studies, including those from the 1000 Genomes Project. The methods and the dataset presented serve as a gold standard for the scientific community allowing us to make recommendations for maximizing structural variation sensitivity for future genome sequencing studies.
606 citations
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TL;DR: In this paper, the authors reviewed the co-pyrolysis process through several points of view, including the process mechanism, feedstock, exploration on co- pyrolyisation studies, co-PyROlysis phenomena, characteristics of byproducts, and economic assessment.
605 citations
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TL;DR: In this article, the authors explored the influences of the active metal, support, promoter, preparation methods, calcination temperature, reducing environment, particle size and reactor choice on catalytic activity and carbon deposition for the dry reforming of methane.
Abstract: This review will explore the influences of the active metal, support, promoter, preparation methods, calcination temperature, reducing environment, particle size and reactor choice on catalytic activity and carbon deposition for the dry reforming of methane Bimetallic (Ni−Pt, Ni−Rh, Ni−Ce, Ni−Mo, Ni−Co) and monometallic (Ni) catalysts are preferred for dry reforming compared to noble metals (Rh, Ru and Pt) due to their low-cost Investigation of support materials indicated that ceria−zirconia mixtures, ZrO2 with alkali metals (Mg2+, Ca2+, Y2+) addition, MgO, SBA-15, ZSM-5, CeO2, BaTiO3 and Ca08Sr02TiO3 showed improved catalytic activities and decreased carbon deposition The modifying effects of cerium (Ce), magnesium (Mg) and yttrium (Y) were significant for dry reforming of methane MgO, CeO2 and La2O3 promoters for metal catalysts supported on mesoporous materials had the highest catalyst stability among all the other promoters Preparation methods played an important role in the synthesis of smaller particle size and higher dispersion of active metals Calcination temperature and treatment duration imparted significant changes to the morphology of catalysts as evident by XRD, TPR and XPS Catalyst reduction in different environments (H2, He, H2/He, O2/He, H2−N2 and CH4/O2) indicated that probably the mixture of reducing agents will lead to enhanced catalytic activities Smaller particle size (
593 citations
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TL;DR: This paper defines MCC, explains its major challenges, discusses heterogeneity in convergent computing and networking, and divides it into two dimensions, namely vertical and horizontal.
Abstract: The unabated flurry of research activities to augment various mobile devices by leveraging heterogeneous cloud resources has created a new research domain called Mobile Cloud Computing (MCC). In the core of such a non-uniform environment, facilitating interoperability, portability, and integration among heterogeneous platforms is nontrivial. Building such facilitators in MCC requires investigations to understand heterogeneity and its challenges over the roots. Although there are many research studies in mobile computing and cloud computing, convergence of these two areas grants further academic efforts towards flourishing MCC. In this paper, we define MCC, explain its major challenges, discuss heterogeneity in convergent computing (i.e. mobile computing and cloud computing) and networking (wired and wireless networks), and divide it into two dimensions, namely vertical and horizontal. Heterogeneity roots are analyzed and taxonomized as hardware, platform, feature, API, and network. Multidimensional heterogeneity in MCC results in application and code fragmentation problems that impede development of cross-platform mobile applications which is mathematically described. The impacts of heterogeneity in MCC are investigated, related opportunities and challenges are identified, and predominant heterogeneity handling approaches like virtualization, middleware, and service oriented architecture (SOA) are discussed. We outline open issues that help in identifying new research directions in MCC.
589 citations
Authors
Showing all 25327 results
Name | H-index | Papers | Citations |
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Diederick E. Grobbee | 155 | 1051 | 122748 |
Intae Yu | 134 | 1372 | 89870 |
Ovsat Abdinov | 129 | 864 | 78489 |
Jyothsna Rani Komaragiri | 129 | 1097 | 82258 |
Odette Benary | 128 | 844 | 74238 |
Paul M. Vanhoutte | 127 | 868 | 62177 |
Irene Vichou | 126 | 762 | 72520 |
Ian O. Ellis | 126 | 1051 | 75435 |
Louisa Degenhardt | 126 | 798 | 139683 |
Matthew Jones | 125 | 1161 | 96909 |
Andrius Juodagalvis | 118 | 1069 | 67138 |
Martin Ravallion | 115 | 570 | 55380 |
R. St. Denis | 112 | 921 | 65326 |
Xiao-Ming Chen | 108 | 596 | 42229 |
A. Yurkewicz | 106 | 514 | 51537 |