University of Malaya

About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.

The R136 star cluster hosts several stars whose individual masses greatly exceed the accepted 150 M⊙ stellar mass limit

Abstract: Spectroscopic analyses of hydrogen-rich WN5‐6 stars within the young star clusters NGC 3603 and R136 are presented, using archival Hubble Space Telescope and Very Large Telescope spectroscopy, and high spatial resolution near-IR photometry, including MultiConjugate Adaptive Optics Demonstrator (MAD) imaging of R136. We derive high stellar temperatures for the WN stars in NGC 3603 (T∗ ∼ 42±2 kK) and R136 (T∗ ∼ 53± 3 kK) plus clumping-corrected mass-loss rates of 2 ‐ 5 ×10 −5 M⊙ yr −1 which closely agree with theoretical predictions from Vink et al. These stars make a disproportionate contribution to the global ionizing and mechanical wind power budget of their host clusters. Indeed, R136a1 alone supplies ∼7% of the ionizing flux of the entire 30 Doradus region. Compar isons with stellar models calculated for the main-sequence evolution of 85 ‐ 500 M⊙ accounting for rotation suggest ages of ∼1.5 Myr and initial masses in the range 105 ‐ 170 M⊙ for three systems in NGC 3603, plus 165 ‐ 320 M⊙ for four stars in R136. Our high stellar masses are supported by consistent spectroscopic and dynamical mass determinations for the components of NGC 3603 A1. We consider the predicted X-ray luminosity of the R136 stars if they were close, colliding wind binaries. R136c is consistent with a colliding wind binary system. However, short period, colliding wind systems are excluded for R136a WN stars if mass ratios are of order unity. Widely separated systems would have been expected to harden owing to early dynamical encounters with other massive stars within such a high density environment. From simulated star clusters, whose constituents are randomly sampled from the Kroupa initial mass function, both NGC 3603 and R136 are consistent with an tentative upper mass limit of ∼300 M⊙. The Arches cluster is either too old to be used to diagnose the upper mass limit, exhibits a deficiency of very massive stars, or mo re likely stellar masses have been underestimated ‐ initial masses for the most luminous stars in the Arches cluster approach 200 M⊙ according to contemporary stellar and photometric results. The potential for stars greatly exceeding 150 M⊙ within metal-poor galaxies suggests that such pair-instab ility supernovae could occur within the local universe, as has been claimed for SN 2007bi.

Measurement of the properties of a Higgs boson in the four-lepton final state

Abstract: Austrian Federal Ministry of Science and Research and the Austrian Science Fund; the Belgian Fonds de la Recherche Scientifique and Fonds voor Wetenschappelijk Onderzoek; the Brazilian Funding Agencies (CNPq, CAPES, FAPERJ, and FAPESP); the Bulgarian Ministry of Education and Science; CERN; the Chinese Academy of Sciences, Ministry of Science and Technology, and National Natural Science Foundation of China; the Colombian Funding Agency (COLCIENCIAS); the Croatian Ministry of Science, Education and Sport, and the Croatian Science Foundation; the Research Promotion Foundation, Cyprus; the Ministry of Education and Research, Recurrent Financing Contract No. SF0690030s09 and European Regional Development Fund, Estonia; the Academy of Finland, Finnish Ministry of Education and Culture, and Helsinki Institute of Physics; the Institut National de Physique Nucleaire et de Physique des Particules/CNRS and Commissariat a l’Energie Atomique et aux Energies Alternatives/CEA, France; the Bundesministerium fur Bildung und Forschung, Deutsche Forschungsgemeinschaft, and Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany; the General Secretariat for Research and Technology, Greece; the National Scientific Research Foundation and National Innovation Office, Hungary; the Department of Atomic Energy and the Department of Science and Technology, India; the Institute for Studies in Theoretical Physics and Mathematics, Iran; the Science Foundation, Ireland; the Istituto Nazionale di Fisica Nucleare, Italy; the Korean Ministry of Education, Science and Technology and the World Class University program of NRF, Republic of Korea; the Lithuanian Academy of Sciences; the Mexican Funding Agencies (CINVESTAV, CONACYT, SEP, and UASLP-FAI); the Ministry of Business, Innovation and Employment, New Zealand; the Pakistan Atomic Energy Commission; the Ministry of Science and Higher Education and the National Science Centre, Poland; the Fundacao para a Ciencia e a Tecnologia, Portugal; JINR, Dubna, the Ministry of Education and Science of the Russian Federation, the Federal Agency of Atomic Energy of the Russian Federation, Russian Academy of Sciences, and the Russian Foundation for Basic Research; the Ministry of Education, Science and Technological Development of Serbia; the Secretaria de Estado de Investigacion, Desarrollo e Innovacion and Programa Consolider-Ingenio 2010, Spain; the Swiss Funding Agencies (ETH Board, ETH Zurich, PSI, SNF, UniZH, Canton Zurich, and SER); the National Science Council, Taipei; the Thailand Center of Excellence in Physics, the Institute for the Promotion of Teaching Science and Technology of Thailand, Special Task Force for Activating Research and the National Science and Technology Development Agency of Thailand; the Scientific and Technical Research Council of Turkey and the Turkish Atomic Energy Authority; the Science and Technology Facilities Council, United Kingdom; the U.S. Department of Energy and the U.S. National Science Foundation.Individuals have received support from the Marie-Curie program and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A. P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation a la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Council of Science and Industrial Research, India; the Compagnia di San Paolo (Torino); the HOMING PLUS programme of Foundation for Polish Science, cofinanced by EU, Regional Development Fund; and the Thalis and Aristeia programmes cofinanced by EU-ESF and the Greek NSRF.

An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

Abstract: Epithelial-mesenchymal transition (EMT) is a form of cellular plasticity that is critical for embryonic development and tumor metastasis. A double-negative feedback loop involving the miR-200 family and ZEB (zinc finger E-box-binding homeobox) transcription factors has been postulated to control the balance between epithelial and mesenchymal states. Here we demonstrate using the epithelial Madin Darby canine kidney cell line model that, although manipulation of the ZEB/miR-200 balance is able to repeatedly switch cells between epithelial and mesenchymal states, the induction and maintenance of a stable mesenchymal phenotype requires the establishment of autocrine transforming growth factor-β (TGF-β) signaling to drive sustained ZEB expression. Furthermore, we show that prolonged autocrine TGF-β signaling induced reversible DNA methylation of the miR-200 loci with corresponding changes in miR-200 levels. Collectively, these findings demonstrate the existence of an autocrine TGF-β/ZEB/miR-200 signaling network that regulates plasticity between epithelial and mesenchymal states. We find a strong correlation between ZEBs and TGF-β and negative correlations between miR-200 and TGF-β and between miR-200 and ZEBs, in invasive ductal carcinomas, consistent with an autocrine TGF-β/ZEB/miR-200 signaling network being active in breast cancers.

Sustainable supplier selection: A ranking model based on fuzzy inference system

Abstract: In these days, considering the growth of knowledge about sustainability in enterprise, the sustainable supplier selection would be the central component in the management of a sustainable supply chain. In this paper the sustainable supplier selection criteria and sub-criteria are determined and based on those criteria and sub-criteria a methodology is proposed onto evaluation and ranking of a given set of suppliers. In the evaluation process, decision makers' opinions on the importance of deciding the criteria and sub-criteria, in addition to their preference of the suppliers' performance with respect to sub-criteria are considered in linguistic terms. To handle the subjectivity of decision makers' assessments, fuzzy logic has been applied and a new ranking method on the basis of fuzzy inference system (FIS) is proposed for supplier selection problem. Finally, an illustrative example is utilized to show the feasibility of the proposed method.

Jet energy scale and resolution in the CMS experiment in pp collisions at 8 TeV

Abstract: Improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented. The corrections as a function of pseudorapidity η and transverse momentum p_T are extracted from data and simulated events combining several channels and methods. They account successively for the effects of pileup, uniformity of the detector response, and residual data-simulation jet energy scale differences. Further corrections, depending on the jet flavor and distance parameter (jet size) R, are also presented. The jet energy resolution is measured in data and simulated events and is studied as a function of pileup, jet size, and jet flavor. Typical jet energy resolutions at the central rapidities are 15–20% at 30 GeV, about 10% at 100 GeV, and 5% at 1 TeV. The studies exploit events with dijet topology, as well as photon+jet, Z+jet and multijet events. Several new techniques are used to account for the various sources of jet energy scale corrections, and a full set of uncertainties, and their correlations, are provided. The final uncertainties on the jet energy scale are below 3% across the phase space considered by most analyses (p_T > 30 GeV and 0|η| 30 GeV is reached, when excluding the jet flavor uncertainties, which are provided separately for different jet flavors. A new benchmark for jet energy scale determination at hadron colliders is achieved with 0.32% uncertainty for jets with p_T of the order of 165–330 GeV, and |η| < 0.8.