Institution
University of Malaya
Education•Kuala Lumpur, Malaysia•
About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.
Topics: Population, Fiber laser, Laser, Ring (chemistry), Electrolyte
Papers published on a yearly basis
Papers
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TL;DR: By suppressing expression of TRAF6 and IRAK1, miR-146a regulates NF-κB activation in T cells through a negative feedback loop and controls the resolution of T cell responses in mice.
Abstract: T cell responses in mammals must be tightly regulated to both provide effective immune protection and avoid inflammation-induced pathology. NF-κB activation is a key signaling event induced by T cell receptor (TCR) stimulation. Dysregulation of NF-κB is associated with T cell–mediated inflammatory diseases and malignancies, highlighting the importance of negative feedback control of TCR-induced NF-κB activity. In this study we show that in mice, T cells lacking miR-146a are hyperactive in both acute antigenic responses and chronic inflammatory autoimmune responses. TCR-driven NF-κB activation up-regulates the expression of miR-146a, which in turn down-regulates NF-κB activity, at least partly through repressing the NF-κB signaling transducers TRAF6 and IRAK1. Thus, our results identify miR-146a as an important new member of the negative feedback loop that controls TCR signaling to NF-κB. Our findings also add microRNA to the list of regulators that control the resolution of T cell responses.
271 citations
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TL;DR: In this article, a new algorithm for distributed generator placement and sizing for distribution systems based on a novel index is proposed, which is developed considering stable node voltages referred as power stability index (PSI), a new analytical approach is adopted to visualize the impact of DG on system losses, voltage profile and voltage stability.
271 citations
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TL;DR: In this paper, the novelty of using waste cooking oil (WCO), which is frequently found as a polluting waste material in landfills and rivers from the food industry, to rejuvenate the bituminous binder was investigated.
271 citations
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TL;DR: In 1998, an outbreak of acute encephalitis with high mortality rates among pig handlers in Malaysia led to the discovery of a novel paramyxovirus named Nipah virus as mentioned in this paper.
Abstract: In 1998, an outbreak of acute encephalitis with high mortality rates among pig handlers in Malaysia led to the discovery of a novel paramyxovirus named Nipah virus. A multidisciplinary investigation that included epidemiology, microbiology, molecular biology, and pathology was pivotal in the discovery of this new human infection. Clinical and autopsy findings were derived from a series of 32 fatal human cases of Nipah virus infection. Diagnosis was established in all cases by a combination of immunohistochemistry (IHC) and serology. Routine histological stains, IHC, and electron microscopy were used to examine autopsy tissues. The main histopathological findings included a systemic vasculitis with extensive thrombosis and parenchymal necrosis, particularly in the central nervous system. Endothelial cell damage, necrosis, and syncytial giant cell formation were seen in affected vessels. Characteristic viral inclusions were seen by light and electron microscopy. IHC analysis showed widespread presence of Nipah virus antigens in endothelial and smooth muscle cells of blood vessels. Abundant viral antigens were also seen in various parenchymal cells, particularly in neurons. Infection of endothelial cells and neurons as well as vasculitis and thrombosis seem to be critical to the pathogenesis of this new human disease.
270 citations
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TL;DR: Eight bacterial strains were isolated from mangrove sediment in Peninsular Malaysia to mitigate the environmental impact of microplastics and develop a clean-up option and the designated isolates degraded the microplastic material and exhibited potential for remediation ofmicroplastic-contaminated environment.
270 citations
Authors
Showing all 25327 results
Name | H-index | Papers | Citations |
---|---|---|---|
Diederick E. Grobbee | 155 | 1051 | 122748 |
Intae Yu | 134 | 1372 | 89870 |
Ovsat Abdinov | 129 | 864 | 78489 |
Jyothsna Rani Komaragiri | 129 | 1097 | 82258 |
Odette Benary | 128 | 844 | 74238 |
Paul M. Vanhoutte | 127 | 868 | 62177 |
Irene Vichou | 126 | 762 | 72520 |
Ian O. Ellis | 126 | 1051 | 75435 |
Louisa Degenhardt | 126 | 798 | 139683 |
Matthew Jones | 125 | 1161 | 96909 |
Andrius Juodagalvis | 118 | 1069 | 67138 |
Martin Ravallion | 115 | 570 | 55380 |
R. St. Denis | 112 | 921 | 65326 |
Xiao-Ming Chen | 108 | 596 | 42229 |
A. Yurkewicz | 106 | 514 | 51537 |