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Institution

University of Marburg

EducationMarburg, Germany
About: University of Marburg is a education organization based out in Marburg, Germany. It is known for research contribution in the topics: Population & Virus. The organization has 23195 authors who have published 42907 publications receiving 1506069 citations. The organization is also known as: Philipps University of Marburg & Philipps-Universität.
Topics: Population, Virus, Gene, Exciton, Photoluminescence


Papers
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Journal ArticleDOI
TL;DR: The balance of evidence suggests that dopaminergic neurones are involved in the light/dark adaptation process in the mammalian retina, and are likely to become model modes of neurochemical action in the nervous system.

262 citations

Journal ArticleDOI
TL;DR: It is demonstrated that N-glycans flanking the receptor-binding site of the HA molecule are potent regulators of influenza virus growth, with the glycan at Asn149 being dominant and that at AsN123 being less effective.
Abstract: The hemagglutinin (HA) of fowl plague virus A/FPV/Rostock/34 (H7N1) carries two N-linked oligosaccharides attached to Asn123 and Asn149 in close vicinity to the receptor-binding pocket. In previous studies in which HA mutants lacking either one (mutants G1 and G2) or both (mutant G1,2) glycosylation sites had been expressed from a simian virus 40 vector, we showed that these glycans regulate receptor binding affinity (M. Ohuchi, R. Ohuchi, A. Feldmann, and H. D. Klenk, J. Virol. 71:8377–8384, 1997). We have now investigated the effect of these mutations on virus growth using recombinant viruses generated by an RNA polymerase I-based reverse genetics system. Two reassortants of influenza virus strain A/WSN/33 were used as helper viruses to obtain two series of HA mutant viruses differing only in the neuraminidase (NA). Studies using N1 NA viruses revealed that loss of the oligosaccharide from Asn149 (mutant G2) or loss of both oligosaccharides (mutant G1,2) has a pronounced effect on virus growth in MDCK cells. Growth of virus lacking both oligosaccharides from infected cells was retarded, and virus yields in the medium were decreased about 20-fold. Likewise, there was a reduction in plaque size that was distinct with G1,2 and less pronounced with G2. These effects could be attributed to a highly impaired release of mutant progeny viruses from host cells. In contrast, with recombinant viruses containing N2 NA, these restrictions were much less apparent. N1 recombinants showed lower neuraminidase activity than N2 recombinants, indicating that N2 NA is able to partly overrule the high-affinity binding of mutant HA to the receptor. These results demonstrate that N-glycans flanking the receptor-binding site of the HA molecule are potent regulators of influenza virus growth, with the glycan at Asn149 being dominant and that at Asn123 being less effective. In addition, we show here that HA and NA activities need to be highly balanced in order to allow productive influenza virus infection.

262 citations

Journal ArticleDOI
TL;DR: It is shown for the first time that patients with schizophrenia can learn volitional brain regulation by rtfMRI feedback training leading to changes in the perception of emotions and modulations of the brain network connectivity.
Abstract: Real-time functional magnetic resonance imaging (rtfMRI) is a novel technique that has allowed subjects to achieve self-regulation of circumscribed brain regions. Despite its anticipated therapeutic benefits, there is no report on successful application of this technique in psychiatric pop- ulations. The objectives of the present study were to train schizophrenia patients to achieve volitional control of bilateral anterior insula cortex on multiple days, and to explore the effect of learned self- regulation on face emotion recognition (an extensively studied deficit in schizophrenia) and on brain network connectivity. Nine patients with schizophrenia were trained to regulate the hemodynamic response in bilateral anterior insula with contingent rtfMRI neurofeedback, through a 2-weeks train- ing. At the end of the training stage, patients performed a face emotion recognition task to explore behavioral effects of learned self-regulation. A learning effect in self-regulation was found for bilat- eral anterior insula, which persisted through the training. Following successful self-regulation, patients recognized disgust faces more accurately and happy faces less accurately. Improvements in disgust recognition were correlated with levels of self-activation of right insula. RtfMRI training led to an increase in the number of the incoming and outgoing effective connections of the anterior insula. This study shows for the first time that patients with schizophrenia can learn volitional brain regulation by rtfMRI feedback training leading to changes in the perception of emotions and modu- lations of the brain network connectivity. These findings open the door for further studies of rtfMRI

262 citations

Journal ArticleDOI
TL;DR: In this 1-day point-prevalence study conducted across Germany, only 24% of all mechanically ventilated patients and only 8% of patients with an endotracheal tube were mobilized out of bed as part of routine care.
Abstract: Objectives:There is growing evidence to support early mobilization of adult mechanically ventilated patients in ICUs. However, there is little knowledge regarding early mobilization in routine ICU practice. Hence, the interdisciplinary German ICU Network for Early Mobilization undertook a 1-day poin

261 citations

Journal ArticleDOI
TL;DR: In this article, a meta-analysis integrates research from 1,015 studies on associations of parenting dimensions and styles with internalizing symptoms in children and adolescents, including parent warmth, behavio...
Abstract: The present meta-analysis integrates research from 1,015 studies on associations of parenting dimensions and styles with internalizing symptoms in children and adolescents. Parental warmth, behavio...

260 citations


Authors

Showing all 23488 results

NameH-indexPapersCitations
John C. Morris1831441168413
Russel J. Reiter1691646121010
Martin J. Blaser147820104104
Christopher T. Walsh13981974314
Markus Cristinziani131114084538
James C. Paulson12644352152
Markus F. Neurath12493462376
Nicholas W. Wood12361466270
Florian Lang116142166496
Howard I. Maibach116182160765
Thomas G. Ksiazek11339846108
Frank Glorius11366349305
Eberhard Ritz111110961530
Manfred T. Reetz11095942941
Wolfgang H. Oertel11065351147
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023142
2022412
20212,103
20201,918
20191,749
20181,592