University of Marburg

About: University of Marburg is a education organization based out in Marburg, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 23195 authors who have published 42907 publications receiving 1506069 citations. The organization is also known as: Philipps University of Marburg & Philipps-Universität.

Transcriptional control by nuclear receptors.

Abstract: Gene regulation by steroid hormones is accomplished by a variety of different mechanisms leading to induction or repression of particular genes. These mechanisms are all mediated by a single class of intracellular hormone receptors, which in the unliganded state are maintained in an inactive form by association with other cellular proteins, including hsp90. Induction of the mouse mammary tumor virus (MMTV) requires binding of the hormone receptor to a hormone-responsive element (HRE) that is precisely organized in a phased nucleosome. After receptor binding, changes in chromatin structure are detected that correlate with binding of transcription factors, including nuclear factor I, to the MMTV promoter. However, although nuclear factor I acts as a basal transcription factor on the MMTV promoter it does not cooperate with the hormone receptors in terms of binding to free DNA, and mutation of the nuclear factor I binding site does not eliminate hormonal stimulation. This residual induction is mediated by oc...

The relation of formal education to ethnic prejudice: Its reliability, validity and explanation

Abstract: This paper examines three issues concerning the frequently documented negative correlation between formal education and ethnic prejudice, namely its reliability, its validity and the manner in which it is mediated. Reliability is demonstrated across three indices of ethnic attitudes in seven representative samples drawn from four European countries (West Germany, Netherlands, France, Great Britain; total N=3788). The hypothesis that this correlation reflects only the tendency of more highly educated respondents to give more socially desirable answers and not true attitude differences was inconsistent with the finding from the survey data that educational level also correlated negatively with responses to an index of subtle prejudice. Results from an experiment employing the bogus pipeline procedure similarly refute this hypothesis, indicating that significant education-related differences in expressed prejudice remain under conditions in which the tendency to give socially desirable responses is reduced. Finally, path analysis based on the survey data show that part but not all of the association between low education and ethnic prejudice is mediated by social psychological variables, particularly group relative deprivation, perceived belief incongruency, political conservatism, and acceptance of inter-ethnic contact.

Molecular mechanisms of liver fibrogenesis--a homage to the role of activated fat-storing cells.

Abstract: During the last few years, considerable progress has been made in the dissection of cellular and molecular mechanisms of hepatic fibrogenesis. The disease, initiated by hepatocellular damage and perpe