Institution
University of Marburg
Education•Marburg, Germany•
About: University of Marburg is a education organization based out in Marburg, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 23195 authors who have published 42907 publications receiving 1506069 citations. The organization is also known as: Philipps University of Marburg & Philipps-Universität.
Topics: Population, Gene, Crystal structure, Laser, Catalysis
Papers published on a yearly basis
Papers
More filters
TL;DR: The results indicate that 15q13.3 microdeletions constitute the most prevalent risk factor for common epilepsies identified to date.
Abstract: We identified 15q13.3 microdeletions encompassing the CHRNA7 gene in 12 of 1,223 individuals with idiopathic generalized epilepsy (IGE), which were not detected in 3,699 controls (joint P = 5.32 x 10(-8)). Most deletion carriers showed common IGE syndromes without other features previously associated with 15q13.3 microdeletions, such as intellectual disability, autism or schizophrenia. Our results indicate that 15q13.3 microdeletions constitute the most prevalent risk factor for common epilepsies identified to date.
533 citations
TL;DR: The results indicated that the CF penetration was inversely related to the size of the liposomes, which was confirmed by the data of the confocal laser scanning microscopy studies.
533 citations
TL;DR: This work shows that deep sleep, light sleep, and rapid eye movement (REM) sleep can be characterized and distinguished by correlations of heart rates separated by n beats, and finds that long-range correlations reminiscent to the wake phase are present only in the REM phase.
Abstract: Healthy sleep consists of several stages: deep sleep, light sleep, and rapid eye movement (REM) sleep. Here we show that these sleep stages can be characterized and distinguished by correlations of heart rates separated by $n$ beats. Using the detrended fluctuation analysis (DFA) up to fourth order we find that long-range correlations reminiscent to the wake phase are present only in the REM phase. In the non-REM phases, the heart rates are uncorrelated above the typical breathing cycle time, pointing to a random regulation of the heartbeat during non-REM sleep.
525 citations
TL;DR: Denosumab showed significantly larger gains in BMD and greater reduction in bone turnover markers compared with alendronate and the overall safety profile was similar for both treatments.
Abstract: Denosumab is a fully human monoclonal antibody that inhibits bone resorption by neutralizing RANKL, a key mediator of osteoclast formation, function, and survival. This phase 3, multicenter, doubleblind study compared the efficacy and safety of denosumab with alendronate in postmenopausal women with low bone mass. One thousand one hundred eighty-nine postmenopausal women with a T-score
524 citations
CEU San Pablo University1, University of Marburg2, National and Kapodistrian University of Athens3, Rush University Medical Center4, University of Toronto5, Toronto Western Hospital6, University of Pennsylvania7, Newcastle University8, University of New South Wales9, University of Sydney10, Peking Union Medical College11, Centre national de la recherche scientifique12, Columbia University13, University of Paris14, Aarhus University15, UCL Institute of Neurology16, National Institutes of Health17, Emory University18, San Francisco VA Medical Center19, University of California, San Francisco20, Veterans Health Administration21, Erasmus University Medical Center22, Baylor College of Medicine23, University of Kiel24, Hebrew University of Jerusalem25, University of Barcelona26, Columbia University Medical Center27, McGill University28, University of Alabama at Birmingham29, Northwestern University30, Icahn School of Medicine at Mount Sinai31, University of Perugia32, University of British Columbia33, Vancouver Coastal Health34
TL;DR: This multiple‐author article provides a historical state‐of‐the‐art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.
Abstract: This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society.
523 citations
Authors
Showing all 23488 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John C. Morris | 183 | 1441 | 168413 |
| Russel J. Reiter | 169 | 1646 | 121010 |
| Martin J. Blaser | 147 | 820 | 104104 |
| Christopher T. Walsh | 139 | 819 | 74314 |
| Markus Cristinziani | 131 | 1140 | 84538 |
| James C. Paulson | 126 | 443 | 52152 |
| Markus F. Neurath | 124 | 934 | 62376 |
| Nicholas W. Wood | 123 | 614 | 66270 |
| Florian Lang | 116 | 1421 | 66496 |
| Howard I. Maibach | 116 | 1821 | 60765 |
| Thomas G. Ksiazek | 113 | 398 | 46108 |
| Frank Glorius | 113 | 663 | 49305 |
| Eberhard Ritz | 111 | 1109 | 61530 |
| Manfred T. Reetz | 110 | 959 | 42941 |
| Wolfgang H. Oertel | 110 | 653 | 51147 |