Institution
University of Marburg
Education•Marburg, Germany•
About: University of Marburg is a education organization based out in Marburg, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 23195 authors who have published 42907 publications receiving 1506069 citations. The organization is also known as: Philipps University of Marburg & Philipps-Universität.
Topics: Population, Gene, Crystal structure, Laser, Catalysis
Papers published on a yearly basis
Papers
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National Institutes of Health1, University of Marburg2, University of Texas Medical Branch3, University of New Mexico4, University of Wisconsin-Madison5, Columbia University Medical Center6, Carlos III Health Institute7, Novosibirsk State University8, Centers for Disease Control and Prevention9, École normale supérieure de Lyon10
TL;DR: The etymological derivation of individual names, their pronunciation, and their correct use are explained, and demarcation criteria for each taxon and virus are elaborate.
Abstract: The taxonomy of the family Filoviridae (marburgviruses and ebolaviruses) has changed several times since the discovery of its members, resulting in a plethora of species and virus names and abbreviations. The current taxonomy has only been partially accepted by most laboratory virologists. Confusion likely arose for several reasons: species names that consist of several words or which (should) contain diacritical marks, the current orthographic identity of species and virus names, and the similar pronunciation of several virus abbreviations in the absence of guidance for the correct use of vernacular names. To rectify this problem, we suggest (1) to retain the current species names Reston ebolavirus, Sudan ebolavirus, and Zaire ebolavirus, but to replace the name Cote d'Ivoire ebolavirus [sic] with Tai Forest ebolavirus and Lake Victoria marburgvirus with Marburg marburgvirus; (2) to revert the virus names of the type marburgviruses and ebolaviruses to those used for decades in the field (Marburg virus instead of Lake Victoria marburgvirus and Ebola virus instead of Zaire ebolavirus); (3) to introduce names for the remaining viruses reminiscent of jargon used by laboratory virologists but nevertheless different from species names (Reston virus, Sudan virus, Tai Forest virus), and (4) to introduce distinct abbreviations for the individual viruses (RESTV for Reston virus, SUDV for Sudan virus, and TAFV for Tai Forest virus), while retaining that for Marburg virus (MARV) and reintroducing that used over decades for Ebola virus (EBOV). Paying tribute to developments in the field, we propose (a) to create a new ebolavirus species (Bundibugyo ebolavirus) for one member virus (Bundibugyo virus, BDBV); (b) to assign a second virus to the species Marburg marburgvirus (Ravn virus, RAVV) for better reflection of now available high-resolution phylogeny; and (c) to create a new tentative genus (Cuevavirus) with one tentative species (Lloviu cuevavirus) for the recently discovered Lloviu virus (LLOV). Furthermore, we explain the etymological derivation of individual names, their pronunciation, and their correct use, and we elaborate on demarcation criteria for each taxon and virus.
417 citations
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TL;DR: In this paper, the wetting of porous templates with polymer melts and solutions or polymer-containing mixtures is a simple and versatile method for the preparation of tubular structures with diameters ranging from a few tens of nanometers to micrometers.
Abstract: The wetting of porous templates with polymer melts and solutions or polymer-containing mixtures is a simple and versatile method for the preparation of tubular structures with diameters ranging from a few tens of nanometers to micrometers. The tube walls can be made of a multitude of materials, some of which have thus far been altogether impossible to use or very limited in their ability to be incorporated into nanostuctures. Template wetting also makes it possible to modify the nanotubes in a variety of ways, for example through the controlled generation of pores or the embedding of nanoparticles into the walls. This method offers a promising approach to functionalized nanotube-template hybrid systems and free-standing nanotubes.
416 citations
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TL;DR: A survey of geographical knowledge spillovers and regional growth can be found in this article, where Doring et al. provide a survey of theoretical and empirical findings highlighting the question of how geographically limited knowledge diffusion can help to explain clusters of regions with persistently different levels of growth.
Abstract: Doring T. and Schnellenbach J. (2006) What do we know about geographical knowledge spillovers and regional growth?: a survey of the literature, Regional Studies 40, 375–395. Modern (endogenous) growth theory tells us that knowledge is crucial for the sustained growth of high-income economies. Against this background, the paper provides a survey of theoretical and empirical findings highlighting the question of how geographically limited knowledge diffusion can help to explain clusters of regions with persistently different levels of growth. It discusses this topic in two steps. First, the theoretical concept of knowledge spillovers is outlined by discussing the different types of knowledge, the spatial dimension of knowledge spillovers, and the geographical mechanisms and structural conditions of knowledge diffusion. Second, it analyses the empirical evidence concerning the theoretical propositions. Doring T. and Schnellenbach J. (2006) What do we know about geographical knowledge spillovers and regional ...
415 citations
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Virginia Tech1, United States Department of Agriculture2, University of Maryland, College Park3, Wageningen University and Research Centre4, European Bioinformatics Institute5, Roche Applied Science6, University of Edinburgh7, Virginia Bioinformatics Institute8, Utah State University9, National Institutes of Health10, University of California, Davis11, Michigan State University12, Texas A&M University13, Leipzig University14, Children's Hospital Oakland Research Institute15, Institute for Animal Health16, Seoul National University17, University of Marburg18, Wellcome Trust Sanger Institute19, University of Delaware20, University of Vienna21, University of Minnesota22
TL;DR: The combined application of next-generation sequencing platforms has provided an economical approach to unlocking the potential of the turkey genome.
Abstract: A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (Meleagris gallopavo). Heterozygosity of the sequenced source genome allowed discovery of more than 600,000 high quality single nucleotide variants. Despite this heterozygosity, the current genome assembly (∼1.1 Gb) includes 917 Mb of sequence assigned to specific turkey chromosomes. Annotation identified nearly 16,000 genes, with 15,093 recognized as protein coding and 611 as non-coding RNA genes. Comparative analysis of the turkey, chicken, and zebra finch genomes, and comparing avian to mammalian species, supports the characteristic stability of avian genomes and identifies genes unique to the avian lineage. Clear differences are seen in number and variety of genes of the avian immune system where expansions and novel genes are less frequent than examples of gene loss. The turkey genome sequence provides resources to further understand the evolution of vertebrate genomes and genetic variation underlying economically important quantitative traits in poultry. This integrated approach may be a model for providing both gene and chromosome level assemblies of other species with agricultural, ecological, and evolutionary interest.
415 citations
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Goethe University Frankfurt1, Charité2, Kyung Hee University3, Lille University of Science and Technology4, University of Paris5, Charles University in Prague6, University of Western Brittany7, Inje University8, Erasmus University Rotterdam9, Harvard University10, University of Turku11, Newcastle University12, University of Hong Kong13, Comenius University in Bratislava14, University of Granada15, University of Nantes16, University of Rennes17, Pierre-and-Marie-Curie University18, French Institute of Health and Medical Research19, University of Milan20, University of Marburg21, Yonsei University22, Instituto Português de Oncologia Francisco Gentil23, Seoul National University24, Hannover Medical School25, University of Padua26, University of Zurich27, University of Hamburg28, University of New South Wales29, Sheba Medical Center30, Tel Aviv University31, University of Copenhagen32, Southmead Hospital33, University of Porto34, University of Catania35, University of Kiel36, University of Silesia in Katowice37, Medical University of Vienna38
TL;DR: Long-distance inverse-polymerase chain reaction was used to characterize the chromosomal rearrangement of individual acute leukemia patients and revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level.
Abstract: Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (∼90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.
414 citations
Authors
Showing all 23488 results
Name | H-index | Papers | Citations |
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John C. Morris | 183 | 1441 | 168413 |
Russel J. Reiter | 169 | 1646 | 121010 |
Martin J. Blaser | 147 | 820 | 104104 |
Christopher T. Walsh | 139 | 819 | 74314 |
Markus Cristinziani | 131 | 1140 | 84538 |
James C. Paulson | 126 | 443 | 52152 |
Markus F. Neurath | 124 | 934 | 62376 |
Nicholas W. Wood | 123 | 614 | 66270 |
Florian Lang | 116 | 1421 | 66496 |
Howard I. Maibach | 116 | 1821 | 60765 |
Thomas G. Ksiazek | 113 | 398 | 46108 |
Frank Glorius | 113 | 663 | 49305 |
Eberhard Ritz | 111 | 1109 | 61530 |
Manfred T. Reetz | 110 | 959 | 42941 |
Wolfgang H. Oertel | 110 | 653 | 51147 |