Institution
University of Marburg
Education•Marburg, Germany•
About: University of Marburg is a education organization based out in Marburg, Germany. It is known for research contribution in the topics: Population & Virus. The organization has 23195 authors who have published 42907 publications receiving 1506069 citations. The organization is also known as: Philipps University of Marburg & Philipps-Universität.
Topics: Population, Virus, Gene, Exciton, Photoluminescence
Papers published on a yearly basis
Papers
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TL;DR: Fredoxin reduction with NADH in cell extracts from Clostridium kluyveri is catalyzed by the butyryl-CoA dehydrogenase/Etf complex and the implications of this finding for the energy metabolism of butyrate-forming anaerobes are discussed in the accompanying paper.
Abstract: Cell extracts of butyrate-forming clostridia have been shown to catalyze acetyl-coenzyme A (acetyl-CoA)- and ferredoxin-dependent formation of H2 from NADH. It has been proposed that these bacteria contain an NADH:ferredoxin oxidoreductase which is allosterically regulated by acetyl-CoA. We report here that ferredoxin reduction with NADH in cell extracts from Clostridium kluyveri is catalyzed by the butyryl-CoA dehydrogenase/Etf complex and that the acetyl-CoA dependence previously observed is due to the fact that the cell extracts catalyze the reduction of acetyl-CoA with NADH via crotonyl-CoA to butyryl-CoA. The cytoplasmic butyryl-CoA dehydrogenase complex was purified and is shown to couple the endergonic reduction of ferredoxin (E0' = -410 mV) with NADH (E0' = -320 mV) to the exergonic reduction of crotonyl-CoA to butyryl-CoA (E0' = -10 mV) with NADH. The stoichiometry of the fully coupled reaction is extrapolated to be as follows: 2 NADH + 1 oxidized ferredoxin + 1 crotonyl-CoA = 2 NAD+ + 1 ferredoxin reduced by two electrons + 1 butyryl-CoA. The implications of this finding for the energy metabolism of butyrate-forming anaerobes are discussed in the accompanying paper.
390 citations
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TL;DR: A mouse model of kidney injury is developed using the Six2-Cre-LoxP technology to selectively activate expression of the simian diphtheria toxin receptor in renal epithelia derived from the metanephric mesenchyme, substantiating a direct role for damaged tubule epithelium in the pathogenesis of CKD.
390 citations
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12 Nov 2015
TL;DR: An electrically pumped polariton laser based on a microcavity containing multiple quantum wells is presented, which can be extended to room-temperature operation using wide-bandgap materials and proves polariton Laser emission unambiguously.
Abstract: Exciton-polaritons are bosonic quasi-particles originating in the strong coupling regime. They can undergo a condensation process leading to coherent emission. We show a realisation of electrically driven polariton condensates using a p-i-n doped microcavity.
390 citations
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TL;DR: A neurocognitive model of online comprehension that accounts for cross-linguistic unity and diversity in the processing of core constituents (verbs and arguments) and can derive the appearance of similar neurophysiological and neuroanatomical processing correlates in seemingly disparate structures in different languages.
Abstract: Real-time language comprehension is a principal cognitive ability and thereby relates to central properties of the human cognitive architecture. Yet how do the presumably universal cognitive and neural substrates of language processing relate to the astounding diversity of human languages (over 5,000)? The authors present a neurocognitive model of online comprehension, the extended argument dependency model (eADM), that accounts for cross-linguistic unity and diversity in the processing of core constituents (verbs and arguments). The eADM postulates that core constituent processing proceeds in three hierarchically organized phases: (1) constituent structure building without relational interpretation, (2) argument role assignment via a restricted set of cross-linguistically motivated information types (e.g., case, animacy), and (3) completion of argument interpretation using information from further domains (e.g., discourse context, plausibility). This basic architecture is assumed to be universal, with cross-linguistic variation deriving primarily from the information types applied in Phase 2 of comprehension. This conception can derive the appearance of similar neurophysiological and neuroanatomical processing correlates in seemingly disparate structures in different languages and, conversely, of cross-linguistic differences in the processing of similar sentence structures.
389 citations
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TL;DR: It is shown that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics in bacteria.
Abstract: Host protection from infection relies on the recognition of pathogens by innate pattern-recognition receptors such as Toll-like receptors (TLRs). Here, we show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably, 23S rRNA from clinical isolates of erythromycin-resistant Staphylococcus aureus and synthetic oligoribonucleotides carrying methylated adenosine or a guanosine mimicking a MLS resistance-causing modification failed to stimulate TLR13. Thus, our results reveal both a natural TLR13 ligand and specific mechanisms of antibiotic resistance as potent bacterial immune evasion strategy, avoiding recognition via TLR13.
389 citations
Authors
Showing all 23488 results
Name | H-index | Papers | Citations |
---|---|---|---|
John C. Morris | 183 | 1441 | 168413 |
Russel J. Reiter | 169 | 1646 | 121010 |
Martin J. Blaser | 147 | 820 | 104104 |
Christopher T. Walsh | 139 | 819 | 74314 |
Markus Cristinziani | 131 | 1140 | 84538 |
James C. Paulson | 126 | 443 | 52152 |
Markus F. Neurath | 124 | 934 | 62376 |
Nicholas W. Wood | 123 | 614 | 66270 |
Florian Lang | 116 | 1421 | 66496 |
Howard I. Maibach | 116 | 1821 | 60765 |
Thomas G. Ksiazek | 113 | 398 | 46108 |
Frank Glorius | 113 | 663 | 49305 |
Eberhard Ritz | 111 | 1109 | 61530 |
Manfred T. Reetz | 110 | 959 | 42941 |
Wolfgang H. Oertel | 110 | 653 | 51147 |