University of Maribor

About: University of Maribor is a education organization based out in Maribor, Slovenia. It is known for research contribution in the topics: Population & KEKB. The organization has 3987 authors who have published 13077 publications receiving 258339 citations. The organization is also known as: Univerza v Mariboru.

Preparation of multi-membrane alginate aerogels used for drug delivery

Abstract: A significant amount of investigation has already taken place into alginate spherical hydrogels’ attractiveness for application as drug delivery carriers. One of their weaknesses is, however, their short lives within dry air conditions. In this study we used a multi-step sol–gel process for generating dry and stable complex alginate aerogels with multi-membranes. Firstly, the formation was performed of spherical hydrogels within a CaCl2 solution. These cores were further immersed in alginate solution, filtered through a sieve, and dropped into the salt solution again. Different multi-membrane hydrogels were obtained by repeating the above process. They were further converted into aerogels by supercritical drying. The effect of the membranes’ numbers was investigated regarding the model drug nicotinic acid's loading and release. The drug loading increased and the drug release was prolonged by adding more membranes around the core. By increasing the amount of drug inside the multi-membrane spheres, the burst drug release was even further inhibited compared to the lower drug-loaded samples.

Stability and Stabilization in Probability of Probabilistic Boolean Networks

Abstract: This article studies the stability in probability of probabilistic Boolean networks and stabilization in the probability of probabilistic Boolean control networks. To simulate more realistic cellular systems, the probability of stability/stabilization is not required to be a strict one. In this situation, the target state is indefinite to have a probability of transferring to itself. Thus, it is a challenging extension of the traditional probability-one problem, in which the self-transfer probability of the target state must be one. Some necessary and sufficient conditions are proposed via the semitensor product of matrices. Illustrative examples are also given to show the effectiveness of the derived results.