University of Maryland, Baltimore County

About: University of Maryland, Baltimore County is a education organization based out in Baltimore, Maryland, United States. It is known for research contribution in the topics: Population & Aerosol. The organization has 8749 authors who have published 20843 publications receiving 795706 citations. The organization is also known as: UMBC.

Planetary Opportunities: A Social Contract for Global Change Science to Contribute to a Sustainable Future

Abstract: The global change research community needs to renew its social contract with society by moving beyond a focus on biophysical limits and toward solution-oriented research to provide realistic, context-specific pathways to a sustainable future. A focus on planetary opportunities is based on the premise that societies adapt to change and have historically implemented solutions-for example, to protect watersheds, improve food security, and reduce harmful atmospheric emissions. Daunting social and biophysical challenges for achieving a sustainable future demand that the global change research community work to provide underpinnings for workable solutions at multiple scales of governance. Global change research must reorient itself from a focus on biophysically oriented, global-scale analysis of humanity's negative impact on the Earth system to consider the needs of decisionmakers from household to global scales. © 2012 by American Institute of Biological Sciences.

Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template

Abstract: Natural and synthetic biological networks must function reliably in the face of fluctuating stoichiometry of their molecular components. These fluctuations are caused in part by changes in relative expression efficiency and the DNA template amount of the network-coding genes. Gene product levels could potentially be decoupled from these changes via built-in adaptation mechanisms, thereby boosting network reliability. Here, we show that a mechanism based on an incoherent feedforward motif enables adaptive gene expression in mammalian cells. We modeled, synthesized, and tested transcriptional and post-transcriptional incoherent loops and found that in all cases the gene product adapts to changes in DNA template abundance. We also observed that the post-transcriptional form results in superior adaptation behavior, higher absolute expression levels, and lower intrinsic fluctuations. Our results support a previously hypothesized endogenous role in gene dosage compensation for such motifs and suggest that their incorporation in synthetic networks will improve their robustness and reliability.

Improving Simulations of Convective Systems from TRMM LBA: Easterly and Westerly Regimes

Abstract: The 3D Goddard Cumulus Ensemble model is used to simulate two convective events observed during the Tropical Rainfall Measuring Mission Large-Scale Biosphere–Atmosphere (TRMM LBA) experiment in Brazil. These two events epitomized the type of convective systems that formed in two distinctly different environments observed during TRMM LBA. The 26 January 1999 squall line formed within a sheared low-level easterly wind flow. On 23 February 1999, convection developed in weak low-level westerly flow, resulting in weakly organized, less intense convection. Initial simulations captured the basic organization and intensity of each event. However, improvements to the model resolution and microphysics produced better simulations as compared to observations. More realistic diurnal convective growth was achieved by lowering the horizontal grid spacing from 1000 to 250 m. This produced a gradual transition from shallow to deep convection that occurred over a span of hours as opposed to an abrupt appearance of...

Appearance of insulin-like growth factor mRNA in the liver and pyloric ceca of a teleost in response to exogenous growth hormone.

Abstract: Augmentation of vertebrate growth by growth hormone (GH) is primarily due to its regulation of insulin-like growth factor I (IGF I) and IGF II levels. To characterize the effect of GH on the levels of IGF I and IGF II mRNA in a teleost, 10 micrograms of bovine GH (bGH) per g of body weight was administered to juvenile rainbow trout (Oncorhynchus mykiss) through i.p. injection. The levels of IGF I and IGF II mRNA were determined simultaneously, by using RNase protection assays, in the liver, pyloric ceca, kidney, and gill at 0, 1, 3, 6, 12, 24, 48, and 72 hr after injection. In the liver, IGF I mRNA levels were significantly elevated at 6 and 12 hr (approximately 2- to 3-fold, P < or = 0.01), while IGF II mRNA levels were significantly elevated at 3 and 6 hr (approximately 3-fold, P < or = 0.01). In the pyloric ceca, IGF II mRNA levels were significantly elevated at 12, 24, and 48 hr (approximately 3-fold, P < or = 0.01), while IGF I mRNA was below the limits of assay accuracy. GH-dependent IGF mRNA appearance was not detected in the gill and kidney. Serum bGH levels, determined by using a radioimmunoassay, were significantly elevated at 3 and 6 hr (P < 0.005). In primary hepatocyte culture, IGF I and IGF II mRNA levels increased in a bGH dose-dependent fashion, with ED50 values of approximately 45 and approximately 6 ng of bGH per ml, respectively. The GH-dependent appearance of IGF II mRNA in the liver and pyloric ceca suggests important roles for this peptide hormone exclusive of IGF I.