University of Maryland, Baltimore County

About: University of Maryland, Baltimore County is a education organization based out in Baltimore, Maryland, United States. It is known for research contribution in the topics: Population & Aerosol. The organization has 8749 authors who have published 20843 publications receiving 795706 citations. The organization is also known as: UMBC.

MODIS leaf area index products: from validation to algorithm improvement

Abstract: Global products of vegetation green Leaf Area Index (LAI) and Fraction of Photosynthetically Active Radiation absorbed by vegetation (FPAR) are being operationally produced from Terra and Aqua Moderate Resolution Imaging Spectroradiometers (MODIS) at 1-km resolution and eight-day frequency. This paper summarizes the experience of several collaborating investigators on validation of MODIS LAI products and demonstrates the close connection between product validation and algorithm refinement activities. The validation of moderate resolution LAI products includes three steps: 1) field sampling representative of LAI spatial distribution and dynamic range within each major land cover type at the validation site; 2) development of a transfer function between field LAI measurements and high resolution satellite data to generate a reference LAI map over an extended area; and 3) comparison of MODIS LAI with aggregated reference LAI map at patch (multipixel) scale in view of geo-location and pixel shift uncertainties. The MODIS LAI validation experiences, summarized here, suggest three key factors that influence the accuracy of LAI retrievals: 1) uncertainties in input land cover data, 2) uncertainties in input surface reflectances, and 3) uncertainties from the model used to build the look-up tables accompanying the algorithm. This strategy of validation efforts guiding algorithm refinements has led to progressively more accurate LAI products from the MODIS sensors aboard NASA's Terra and Aqua platforms

The Design and Fabrication of Three‐Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

Abstract: Whole animal testing is an essential part in evaluating the toxicological and pharmacological profiles of chemicals and pharmaceuticals, but these experiments are expensive and cumbersome. A cell culture analog (CCA) system, when used in conjunction with a physiologically based pharmacokinetic (PBPK) model, provides an in vitro supplement to animal studies and the possibility of a human surrogate for predicting human response in clinical trials. A PBPK model mathematically simulates animal metabolism by modeling the absorption, distribution, metabolism, and elimination kinetics of a chemical in interconnected tissue compartments. A CCA uses mammalian cells cultured in interconnected chambers to physically represent the corresponding PBPK. These compartments are connected by recirculating tissue culture medium that acts as a blood surrogate. The purpose of this article is to describe the design and basic operation of the microscale manifestation of such a system. Microscale CCAs offer the potential for inexpensive, relatively high throughput evaluation of chemicals while minimizing demand for reagents and cells. Using microfabrication technology, a three-chamber ("lung"-"liver"-"other") microscale cell culture analog (microCCA) device was fabricated on a 1 in. (2.54 cm) square silicon chip. With a design flow rate of 1.76 microL/min, this microCCA device achieves approximate physiological liquid-to-cell ratio and hydrodynamic shear stress while replicating the liquid residence time parameters in the PBPK model. A dissolved oxygen sensor based on collision quenching of a fluorescent ruthenium complex by oxygen molecules was integrated into the system, demonstrating the potential to integrate real-time sensors into such devices.