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Showing papers by "University of Maryland, College Park published in 2021"


Journal ArticleDOI
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

1,129 citations


Journal ArticleDOI
TL;DR: A broad-scope overview provides an integrative approach for considering the implications of COVID-19 for work, workers, and organizations while also identifying issues for future research and insights to inform solutions.
Abstract: The impacts of COVID-19 on workers and workplaces across the globe have been dramatic. This broad review of prior research rooted in work and organizational psychology, and related fields, is intended to make sense of the implications for employees, teams, and work organizations. This review and preview of relevant literatures focuses on (a) emergent changes in work practices (e.g., working from home, virtual teamwork) and (b) emergent changes for workers (e.g., social distancing, stress, and unemployment). In addition, potential moderating factors (demographic characteristics, individual differences, and organizational norms) are examined given the likelihood that COVID-19 will generate disparate effects. This broad-scope overview provides an integrative approach for considering the implications of COVID-19 for work, workers, and organizations while also identifying issues for future research and insights to inform solutions. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

654 citations


Journal ArticleDOI
Arang Rhie1, Shane A. McCarthy2, Shane A. McCarthy3, Olivier Fedrigo4, Joana Damas5, Giulio Formenti4, Sergey Koren1, Marcela Uliano-Silva6, William Chow3, Arkarachai Fungtammasan, J. H. Kim7, Chul Hee Lee7, Byung June Ko7, Mark Chaisson8, Gregory Gedman4, Lindsey J. Cantin4, Françoise Thibaud-Nissen1, Leanne Haggerty9, Iliana Bista2, Iliana Bista3, Michelle Smith3, Bettina Haase4, Jacquelyn Mountcastle4, Sylke Winkler10, Sylke Winkler11, Sadye Paez4, Jason T. Howard, Sonja C. Vernes12, Sonja C. Vernes13, Sonja C. Vernes11, Tanya M. Lama14, Frank Grützner15, Wesley C. Warren16, Christopher N. Balakrishnan17, Dave W Burt18, Jimin George19, Matthew T. Biegler4, David Iorns, Andrew Digby, Daryl Eason, Bruce C. Robertson20, Taylor Edwards21, Mark Wilkinson22, George F. Turner23, Axel Meyer24, Andreas F. Kautt25, Andreas F. Kautt24, Paolo Franchini24, H. William Detrich26, Hannes Svardal27, Hannes Svardal28, Maximilian Wagner29, Gavin J. P. Naylor30, Martin Pippel11, Milan Malinsky31, Milan Malinsky3, Mark Mooney, Maria Simbirsky, Brett T. Hannigan, Trevor Pesout32, Marlys L. Houck33, Ann C Misuraca33, Sarah B. Kingan34, Richard Hall34, Zev N. Kronenberg34, Ivan Sović34, Christopher Dunn34, Zemin Ning3, Alex Hastie, Joyce V. Lee, Siddarth Selvaraj, Richard E. Green32, Nicholas H. Putnam, Ivo Gut35, Jay Ghurye36, Erik Garrison32, Ying Sims3, Joanna Collins3, Sarah Pelan3, James Torrance3, Alan Tracey3, Jonathan Wood3, Robel E. Dagnew8, Dengfeng Guan37, Dengfeng Guan2, Sarah E. London38, David F. Clayton19, Claudio V. Mello39, Samantha R. Friedrich39, Peter V. Lovell39, Ekaterina Osipova11, Farooq O. Al-Ajli40, Farooq O. Al-Ajli41, Simona Secomandi42, Heebal Kim7, Constantina Theofanopoulou4, Michael Hiller43, Yang Zhou, Robert S. Harris44, Kateryna D. Makova44, Paul Medvedev44, Jinna Hoffman1, Patrick Masterson1, Karen Clark1, Fergal J. Martin9, Kevin L. Howe9, Paul Flicek9, Brian P. Walenz1, Woori Kwak, Hiram Clawson32, Mark Diekhans32, Luis R Nassar32, Benedict Paten32, Robert H. S. Kraus11, Robert H. S. Kraus24, Andrew J. Crawford45, M. Thomas P. Gilbert46, M. Thomas P. Gilbert47, Guojie Zhang, Byrappa Venkatesh48, Robert W. Murphy49, Klaus-Peter Koepfli50, Beth Shapiro32, Beth Shapiro51, Warren E. Johnson52, Warren E. Johnson50, Federica Di Palma53, Tomas Marques-Bonet, Emma C. Teeling54, Tandy Warnow55, Jennifer A. Marshall Graves56, Oliver A. Ryder57, Oliver A. Ryder33, David Haussler32, Stephen J. O'Brien58, Jonas Korlach34, Harris A. Lewin5, Kerstin Howe3, Eugene W. Myers11, Eugene W. Myers10, Richard Durbin2, Richard Durbin3, Adam M. Phillippy1, Erich D. Jarvis4, Erich D. Jarvis51 
National Institutes of Health1, University of Cambridge2, Wellcome Trust Sanger Institute3, Rockefeller University4, University of California, Davis5, Leibniz Association6, Seoul National University7, University of Southern California8, European Bioinformatics Institute9, Dresden University of Technology10, Max Planck Society11, University of St Andrews12, Radboud University Nijmegen13, University of Massachusetts Amherst14, University of Adelaide15, University of Missouri16, East Carolina University17, University of Queensland18, Clemson University19, University of Otago20, University of Arizona21, Natural History Museum22, Bangor University23, University of Konstanz24, Harvard University25, Northeastern University26, National Museum of Natural History27, University of Antwerp28, University of Graz29, University of Florida30, University of Basel31, University of California, Santa Cruz32, Zoological Society of San Diego33, Pacific Biosciences34, Pompeu Fabra University35, University of Maryland, College Park36, Harbin Institute of Technology37, University of Chicago38, Oregon Health & Science University39, Qatar Airways40, Monash University Malaysia Campus41, University of Milan42, Goethe University Frankfurt43, Pennsylvania State University44, University of Los Andes45, Norwegian University of Science and Technology46, University of Copenhagen47, Agency for Science, Technology and Research48, Royal Ontario Museum49, Smithsonian Institution50, Howard Hughes Medical Institute51, Walter Reed Army Institute of Research52, University of East Anglia53, University College Dublin54, University of Illinois at Urbana–Champaign55, La Trobe University56, University of California, San Diego57, Nova Southeastern University58
28 Apr 2021-Nature
TL;DR: The Vertebrate Genomes Project (VGP) as mentioned in this paper is an international effort to generate high quality, complete reference genomes for all of the roughly 70,000 extant vertebrate species and to help to enable a new era of discovery across the life sciences.
Abstract: High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such assemblies are available for only a few non-microbial species1-4. To address this issue, the international Genome 10K (G10K) consortium5,6 has worked over a five-year period to evaluate and develop cost-effective methods for assembling highly accurate and nearly complete reference genomes. Here we present lessons learned from generating assemblies for 16 species that represent six major vertebrate lineages. We confirm that long-read sequencing technologies are essential for maximizing genome quality, and that unresolved complex repeats and haplotype heterozygosity are major sources of assembly error when not handled correctly. Our assemblies correct substantial errors, add missing sequence in some of the best historical reference genomes, and reveal biological discoveries. These include the identification of many false gene duplications, increases in gene sizes, chromosome rearrangements that are specific to lineages, a repeated independent chromosome breakpoint in bat genomes, and a canonical GC-rich pattern in protein-coding genes and their regulatory regions. Adopting these lessons, we have embarked on the Vertebrate Genomes Project (VGP), an international effort to generate high-quality, complete reference genomes for all of the roughly 70,000 extant vertebrate species and to help to enable a new era of discovery across the life sciences.

647 citations


Journal ArticleDOI
03 Feb 2021-Nature
TL;DR: This work explores the use of fibrillated cellulose in the fabrication of materials ranging from composites and macrofibres, to thin films, porous membranes and gels, and discusses research directions for the practical exploitation of these structures.
Abstract: Cellulose is the most abundant biopolymer on Earth, found in trees, waste from agricultural crops and other biomass The fibres that comprise cellulose can be broken down into building blocks, known as fibrillated cellulose, of varying, controllable dimensions that extend to the nanoscale Fibrillated cellulose is harvested from renewable resources, so its sustainability potential combined with its other functional properties (mechanical, optical, thermal and fluidic, for example) gives this nanomaterial unique technological appeal Here we explore the use of fibrillated cellulose in the fabrication of materials ranging from composites and macrofibres, to thin films, porous membranes and gels We discuss research directions for the practical exploitation of these structures and the remaining challenges to overcome before fibrillated cellulose materials can reach their full potential Finally, we highlight some key issues towards successful manufacturing scale-up of this family of materials

517 citations


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1428 moreInstitutions (155)
TL;DR: In this article, the population of 47 compact binary mergers detected with a false-alarm rate of 0.614 were dynamically assembled, and the authors found that the BBH rate likely increases with redshift, but not faster than the star formation rate.
Abstract: We report on the population of 47 compact binary mergers detected with a false-alarm rate of 0.01 are dynamically assembled. Third, we estimate merger rates, finding RBBH = 23.9-+8.614.3 Gpc-3 yr-1 for BBHs and RBNS = 320-+240490 Gpc-3 yr-1 for binary neutron stars. We find that the BBH rate likely increases with redshift (85% credibility) but not faster than the star formation rate (86% credibility). Additionally, we examine recent exceptional events in the context of our population models, finding that the asymmetric masses of GW190412 and the high component masses of GW190521 are consistent with our models, but the low secondary mass of GW190814 makes it an outlier.

468 citations


Journal ArticleDOI
TL;DR: Monroe et al. as discussed by the authors used a laser-cooled and trapped atomic ions for the simulation of interacting quantum spin models, where effective spins are represented by appropriate internal energy levels within each ion, and the spins can be measured with near-perfect efficiency using state-dependent fluorescence techniques.
Abstract: Author(s): Monroe, C; Campbell, WC; Duan, LM; Gong, ZX; Gorshkov, AV; Hess, PW; Islam, R; Kim, K; Linke, NM; Pagano, G; Richerme, P; Senko, C; Yao, NY | Abstract: Laser-cooled and trapped atomic ions form an ideal standard for the simulation of interacting quantum spin models. Effective spins are represented by appropriate internal energy levels within each ion, and the spins can be measured with near-perfect efficiency using state-dependent fluorescence techniques. By applying optical fields that exert optical dipole forces on the ions, their Coulomb interaction can be modulated to produce long-range and tunable spin-spin interactions that can be reconfigured by shaping the spectrum and pattern of the laser fields in a prototypical example of a quantum simulator. Here the theoretical mapping of atomic ions to interacting spin systems, the preparation of complex equilibrium states, and the study of dynamical processes in these many-body interacting quantum systems are reviewed, and the use of this platform for optimization and other tasks is discussed. The use of such quantum simulators for studying spin models may inform our understanding of exotic quantum materials and shed light on the behavior of interacting quantum systems that cannot be modeled with conventional computers.

413 citations


Journal ArticleDOI
TL;DR: In this paper, the molecular mechanisms underlying the responses of plants to abiotic stresses emphasizes their multilevel nature; multiple processes are involved, including sensing, signalling, transcription, transcript processing, translation and post-translational protein modifications.
Abstract: Plants cannot move, so they must endure abiotic stresses such as drought, salinity and extreme temperatures. These stressors greatly limit the distribution of plants, alter their growth and development, and reduce crop productivity. Recent progress in our understanding of the molecular mechanisms underlying the responses of plants to abiotic stresses emphasizes their multilevel nature; multiple processes are involved, including sensing, signalling, transcription, transcript processing, translation and post-translational protein modifications. This improved knowledge can be used to boost crop productivity and agricultural sustainability through genetic, chemical and microbial approaches.

397 citations


Journal ArticleDOI
01 Jan 2021-Science
TL;DR: In this paper, a zinc-O2/zinc peroxide (ZnO2) chemistry was proposed, which enables highly reversible redox reactions in zinc-air batteries.
Abstract: Rechargeable alkaline zinc-air batteries promise high energy density and safety but suffer from the sluggish 4 electron (e-)/oxygen (O2) chemistry that requires participation of water and from the electrochemical irreversibility originating from parasitic reactions caused by caustic electrolytes and atmospheric carbon dioxide. Here, we report a zinc-O2/zinc peroxide (ZnO2) chemistry that proceeds through a 2e-/O2 process in nonalkaline aqueous electrolytes, which enables highly reversible redox reactions in zinc-air batteries. This ZnO2 chemistry was made possible by a water-poor and zinc ion (Zn2+)-rich inner Helmholtz layer on the air cathode caused by the hydrophobic trifluoromethanesulfonate anions. The nonalkaline zinc-air battery thus constructed not only tolerates stable operations in ambient air but also exhibits substantially better reversibility than its alkaline counterpart.

377 citations


Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1692 moreInstitutions (195)
TL;DR: In this article, the authors reported the observation of gravitational waves from two compact binary coalescences in LIGO's and Virgo's third observing run with properties consistent with neutron star-black hole (NSBH) binaries.
Abstract: We report the observation of gravitational waves from two compact binary coalescences in LIGO’s and Virgo’s third observing run with properties consistent with neutron star–black hole (NSBH) binaries. The two events are named GW200105_162426 and GW200115_042309, abbreviated as GW200105 and GW200115; the first was observed by LIGO Livingston and Virgo and the second by all three LIGO–Virgo detectors. The source of GW200105 has component masses 8.9−1.5+1.2 and 1.9−0.2+0.3M⊙ , whereas the source of GW200115 has component masses 5.7−2.1+1.8 and 1.5−0.3+0.7M⊙ (all measurements quoted at the 90% credible level). The probability that the secondary’s mass is below the maximal mass of a neutron star is 89%–96% and 87%–98%, respectively, for GW200105 and GW200115, with the ranges arising from different astrophysical assumptions. The source luminosity distances are 280−110+110 and 300−100+150Mpc , respectively. The magnitude of the primary spin of GW200105 is less than 0.23 at the 90% credible level, and its orientation is unconstrained. For GW200115, the primary spin has a negative spin projection onto the orbital angular momentum at 88% probability. We are unable to constrain the spin or tidal deformation of the secondary component for either event. We infer an NSBH merger rate density of 45−33+75Gpc−3yr−1 when assuming that GW200105 and GW200115 are representative of the NSBH population or 130−69+112Gpc−3yr−1 under the assumption of a broader distribution of component masses.

374 citations


Journal ArticleDOI
TL;DR: MaAsLin 2 (Microbiome Multivariable Associations with Linear Models) as mentioned in this paper uses generalized linear and mixed models to accommodate a wide variety of modern epidemiological studies, including cross-sectional and longitudinal designs, as well as a variety of data types with or without covariates and repeated measurements.
Abstract: It is challenging to associate features such as human health outcomes, diet, environmental conditions, or other metadata to microbial community measurements, due in part to their quantitative properties. Microbiome multi-omics are typically noisy, sparse (zero-inflated), high-dimensional, extremely non-normal, and often in the form of count or compositional measurements. Here we introduce an optimized combination of novel and established methodology to assess multivariable association of microbial community features with complex metadata in population-scale observational studies. Our approach, MaAsLin 2 (Microbiome Multivariable Associations with Linear Models), uses generalized linear and mixed models to accommodate a wide variety of modern epidemiological studies, including cross-sectional and longitudinal designs, as well as a variety of data types (e.g., counts and relative abundances) with or without covariates and repeated measurements. To construct this method, we conducted a large-scale evaluation of a broad range of scenarios under which straightforward identification of meta-omics associations can be challenging. These simulation studies reveal that MaAsLin 2's linear model preserves statistical power in the presence of repeated measures and multiple covariates, while accounting for the nuances of meta-omics features and controlling false discovery. We also applied MaAsLin 2 to a microbial multi-omics dataset from the Integrative Human Microbiome (HMP2) project which, in addition to reproducing established results, revealed a unique, integrated landscape of inflammatory bowel diseases (IBD) across multiple time points and omics profiles.

369 citations


Journal ArticleDOI
TL;DR: In this article, the authors reported a radius measurement based on fits of rotating hot spot patterns to Neutron Star Interior Composition Explorer (NICER) and X-ray Multi-Mirror (XMM-Newton) observations.
Abstract: PSR J0740$+$6620 has a gravitational mass of $2.08\pm 0.07~M_\odot$, which is the highest reliably determined mass of any neutron star. As a result, a measurement of its radius will provide unique insight into the properties of neutron star core matter at high densities. Here we report a radius measurement based on fits of rotating hot spot patterns to Neutron Star Interior Composition Explorer (NICER) and X-ray Multi-Mirror (XMM-Newton) X-ray observations. We find that the equatorial circumferential radius of PSR J0740$+$6620 is $13.7^{+2.6}_{-1.5}$ km (68%). We apply our measurement, combined with the previous NICER mass and radius measurement of PSR J0030$+$0451, the masses of two other $\sim 2~M_\odot$ pulsars, and the tidal deformability constraints from two gravitational wave events, to three different frameworks for equation of state modeling, and find consistent results at $\sim 1.5-3$ times nuclear saturation density. For a given framework, when all measurements are included the radius of a $1.4~M_\odot$ neutron star is known to $\pm 4$% (68% credibility) and the radius of a $2.08~M_\odot$ neutron star is known to $\pm 5$%. The full radius range that spans the $\pm 1\sigma$ credible intervals of all the radius estimates in the three frameworks is $12.45\pm 0.65$ km for a $1.4~M_\odot$ neutron star and $12.35\pm 0.75$ km for a $2.08~M_\odot$ neutron star.

Journal ArticleDOI
TL;DR: In this paper, an anode-free aqueous zinc battery with an alkylammonium salt additive has been developed, which enables the formation of a robust, Zn2+conducting and waterproof SEI.
Abstract: Metallic zinc is an ideal anode due to its high theoretical capacity (820 mAh g−1), low redox potential (−0.762 V versus the standard hydrogen electrode), high abundance and low toxicity. When used in aqueous electrolyte, it also brings intrinsic safety, but suffers from severe irreversibility. This is best exemplified by low coulombic efficiency, dendrite growth and water consumption. This is thought to be due to severe hydrogen evolution during zinc plating and stripping, hitherto making the in-situ formation of a solid–electrolyte interphase (SEI) impossible. Here, we report an aqueous zinc battery in which a dilute and acidic aqueous electrolyte with an alkylammonium salt additive assists the formation of a robust, Zn2+-conducting and waterproof SEI. The presence of this SEI enables excellent performance: dendrite-free zinc plating/stripping at 99.9% coulombic efficiency in a Ti||Zn asymmetric cell for 1,000 cycles; steady charge–discharge in a Zn||Zn symmetric cell for 6,000 cycles (6,000 h); and high energy densities (136 Wh kg−1 in a Zn||VOPO4 full battery with 88.7% retention for >6,000 cycles, 325 Wh kg−1 in a Zn||O2 full battery for >300 cycles and 218 Wh kg−1 in a Zn||MnO2 full battery with 88.5% retention for 1,000 cycles) using limited zinc. The SEI-forming electrolyte also allows the reversible operation of an anode-free pouch cell of Ti||ZnxVOPO4 at 100% depth of discharge for 100 cycles, thus establishing aqueous zinc batteries as viable cell systems for practical applications. A solid–electrolyte interphase that is permeable to Zn(ii) ions but waterproof is formed using an aqueous electrolyte composition. Cycling performances in an anode-free aqueous pouch cell show promise for intrinsically safe energy storage applications.

Journal ArticleDOI
TL;DR: In this article, the authors estimate the radius, mass, and hot surface regions of the massive millisecond pulsar PSR J0740$+$6620, conditional on pulse profile modeling of Neutron Star Interior Composition Explorer X-ray Timing Instrument (NICER XTI) event data.
Abstract: We report on Bayesian estimation of the radius, mass, and hot surface regions of the massive millisecond pulsar PSR J0740$+$6620, conditional on pulse-profile modeling of Neutron Star Interior Composition Explorer X-ray Timing Instrument (NICER XTI) event data. We condition on informative pulsar mass, distance, and orbital inclination priors derived from the joint NANOGrav and CHIME/Pulsar wideband radio timing measurements of arXiv:2104.00880. We use XMM European Photon Imaging Camera spectroscopic event data to inform our X-ray likelihood function. The prior support of the pulsar radius is truncated at 16 km to ensure coverage of current dense matter models. We assume conservative priors on instrument calibration uncertainty. We constrain the equatorial radius and mass of PSR J0740$+$6620 to be $12.39_{-0.98}^{+1.30}$ km and $2.072_{-0.066}^{+0.067}$ M$_{\odot}$ respectively, each reported as the posterior credible interval bounded by the 16% and 84% quantiles, conditional on surface hot regions that are non-overlapping spherical caps of fully-ionized hydrogen atmosphere with uniform effective temperature; a posteriori, the temperature is $\log_{10}(T$ [K]$)=5.99_{-0.06}^{+0.05}$ for each hot region. All software for the X-ray modeling framework is open-source and all data, model, and sample information is publicly available, including analysis notebooks and model modules in the Python language. Our marginal likelihood function of mass and equatorial radius is proportional to the marginal joint posterior density of those parameters (within the prior support) and can thus be computed from the posterior samples.

Journal ArticleDOI
TL;DR: In this paper, the Global Ecosystem Dynamics Investigation (GEDI) lidar instrument onboard the International Space Station has been collecting unique data on vegetation structure since April 2019, and the authors employed global Landsat analysis-ready data to extrapolate GEDI footprint-level forest canopy height measurements.

Journal ArticleDOI
TL;DR: The SecureBoost framework is shown to be as accurate as other nonfederated gradient tree-boosting algorithms that require centralized data, and thus, it is highly scalable and practical for industrial applications such as credit risk analysis.
Abstract: The protection of user privacy is an important concern in machine learning, as evidenced by the rolling out of the General Data Protection Regulation (GDPR) in the European Union (EU) in May 2018 The GDPR is designed to give users more control over their personal data, which motivates us to explore machine learning frameworks for data sharing that do not violate user privacy To meet this goal, in this paper, we propose a novel lossless privacy-preserving tree-boosting system known as SecureBoost in the setting of federated learning This federated-learning system allows the learning process to be jointly conducted over multiple parties with partially common user samples but different feature sets, which corresponds to a vertically partitioned data set An advantage of SecureBoost is that it provides the same level of accuracy as the non privacy-preserving approach while at the same time, reveals no information of each private data provider We formally prove that the SecureBoost framework is as accurate as other non-federated gradient tree-boosting algorithms that concentrate data in one place In addition, we describe information leakage during the protocol execution and propose ways to provably reduce it

Journal ArticleDOI
Richard J. Abbott1, T. D. Abbott2, Sheelu Abraham3, Fausto Acernese4  +1335 moreInstitutions (144)
TL;DR: The data recorded by these instruments during their first and second observing runs are described, including the gravitational-wave strain arrays, released as time series sampled at 16384 Hz.

Journal ArticleDOI
TL;DR: Li et al. as mentioned in this paper proposed a Space-Time Extra-Trees (STET) model to capture the spatiotemporal variations of PM2.5 at different spatial scales.

Journal ArticleDOI
TL;DR: The mRNA-1273 vaccine showed 94.1% efficacy in preventing coronavirus disease 2019 (Covid-... as discussed by the authors ) in a phase 3, observer-blinded, placebo-controlled clinical trial.
Abstract: Background At interim analysis in a phase 3, observer-blinded, placebo-controlled clinical trial, the mRNA-1273 vaccine showed 94.1% efficacy in preventing coronavirus disease 2019 (Covid-...

Journal ArticleDOI
TL;DR: The required properties of the sulfide electrolytes, such as the electrochemical stabilities of the electrolytes and the compatible electrode/electrolyte interfaces are highlighted, and the opportunities for sulfide-based ASSLBs are discussed.
Abstract: All-solid-state lithium batteries (ASSLBs) are considered as the next generation electrochemical energy storage devices because of their high safety and energy density, simple packaging, and wide operable temperature range. The critical component in ASSLBs is the solid-state electrolyte. Among all solid-state electrolytes, the sulfide electrolytes have the highest ionic conductivity and favorable interface compatibility with sulfur-based cathodes. The ionic conductivity of sulfide electrolytes is comparable with or even higher than that of the commercial organic liquid electrolytes. However, several critical challenges for sulfide electrolytes still remain to be solved, including their narrow electrochemical stability window, the unstable interface between the electrolyte and the electrodes, as well as lithium dendrite formation in the electrolytes. Herein, the emerging sulfide electrolytes and preparation methods are reviewed. In particular, the required properties of the sulfide electrolytes, such as the electrochemical stabilities of the electrolytes and the compatible electrode/electrolyte interfaces are highlighted. The opportunities for sulfide-based ASSLBs are also discussed.

Journal ArticleDOI
TL;DR: In this paper, the authors present estimates of greenhouse gas emissions trends by sector from 1990 to 2018, describing the major sources of emissions growth, stability and decline across ten global regions.
Abstract: Global greenhouse gas emissions can be traced to five economic sectors: energy, industry, buildings, transport and AFOLU (agriculture, forestry and other land uses). In this topical review we synthesize the literature to explain recent trends in global and regional emissions in each of these sectors. To contextualise our review, we present estimates of greenhouse gas emissions trends by sector from 1990 to 2018, describing the major sources of emissions growth, stability and decline across ten global regions. Both the literature and data emphasize limited progress towards reducing greenhouse gas emissions. The prominent global pattern is a continuation of underlying drivers with few signs of emerging limits to demand, nor of a deep shift towards the delivery of low and zero carbon services across sectors. We observe a moderate decarbonisation of energy systems in Europe and North America, driven by fuel switching and the increasing penetration of renewables. By contrast, in rapidly industrialising regions, fossil-based energy systems have continuously expanded, only very recently slowing down in their growth. Strong demand for materials, floor area, energy services and travel have driven emissions growth in the industry, buildings and transport sectors, particularly in Eastern Asia, Southern Asia and South-East Asia. An expansion of agriculture into carbon-dense tropical forest areas has driven recent increases in AFOLU emissions in Latin America, South-East Asia and Africa. Identifying, understanding, and tackling the most persistent and climate-damaging trends across sectors is a fundamental concern for research and policy as humanity treads deeper into the Anthropocene.

Journal ArticleDOI
TL;DR: In this paper, the authors integrated ground and Earth observation data to map annual forest-related greenhouse gas emissions and removals globally at a spatial resolution of 30'm over the years 2001-2019.
Abstract: Managing forests for climate change mitigation requires action by diverse stakeholders undertaking different activities with overlapping objectives and spatial impacts. To date, several forest carbon monitoring systems have been developed for different regions using various data, methods and assumptions, making it difficult to evaluate mitigation performance consistently across scales. Here, we integrate ground and Earth observation data to map annual forest-related greenhouse gas emissions and removals globally at a spatial resolution of 30 m over the years 2001–2019. We estimate that global forests were a net carbon sink of −7.6 ± 49 GtCO2e yr−1, reflecting a balance between gross carbon removals (−15.6 ± 49 GtCO2e yr−1) and gross emissions from deforestation and other disturbances (8.1 ± 2.5 GtCO2e yr−1). The geospatial monitoring framework introduced here supports climate policy development by promoting alignment and transparency in setting priorities and tracking collective progress towards forest-specific climate mitigation goals with both local detail and global consistency.

Journal ArticleDOI
TL;DR: This framework lays out guidelines of how to use different AIs to engage customers based on considerations of nature of service task, service offering, service strategy, and service process, providing managerial guidelines for service providers to leverage the advantages of AI.
Abstract: This article develops a strategic framework for using artificial intelligence (AI) to engage customers for different service benefits. This framework lays out guidelines of how to use different AIs...

Journal ArticleDOI
TL;DR: In this paper, the authors propose a standardized process for documenting datasets, which can lead to severe consequences in high-stakes domains, such as data privacy and data transparency, and encourage the machine learning community to prioritize transparency and accountability.
Abstract: The machine learning community currently has no standardized process for documenting datasets, which can lead to severe consequences in high-stakes domains. To address this gap, we propose datasheets for datasets. In the electronics industry, every component, no matter how simple or complex, is accompanied with a datasheet that describes its operating characteristics, test results, recommended uses, and other information. By analogy, we propose that every dataset be accompanied with a datasheet that documents its motivation, composition, collection process, recommended uses, and so on. Datasheets for datasets will facilitate better communication between dataset creators and dataset consumers, and encourage the machine learning community to prioritize transparency and accountability.

Journal ArticleDOI
TL;DR: A three-stage framework for strategic marketing planning, incorporating multiple artificial intelligence (AI) benefits: mechanical AI for automating repetitive marketing functions and activities, thinking AI for processing data to arrive at decisions, and feeling AI for analyzing interactions and human emotions is developed.
Abstract: The authors develop a three-stage framework for strategic marketing planning, incorporating multiple artificial intelligence (AI) benefits: mechanical AI for automating repetitive marketing functions and activities, thinking AI for processing data to arrive at decisions, and feeling AI for analyzing interactions and human emotions. This framework lays out the ways that AI can be used for marketing research, strategy (segmentation, targeting, and positioning, STP), and actions. At the marketing research stage, mechanical AI can be used for data collection, thinking AI for market analysis, and feeling AI for customer understanding. At the marketing strategy (STP) stage, mechanical AI can be used for segmentation (segment recognition), thinking AI for targeting (segment recommendation), and feeling AI for positioning (segment resonance). At the marketing action stage, mechanical AI can be used for standardization, thinking AI for personalization, and feeling AI for relationalization. We apply this framework to various areas of marketing, organized by marketing 4Ps/4Cs, to illustrate the strategic use of AI.

Journal ArticleDOI
TL;DR: A new theory quantifying product formulas' errors puts these algorithms on a rigorous foundation, showcasing their superiority over other methods.
Abstract: Product formulas offer a powerful, simple approach to quantum simulation. A new theory quantifying their errors puts these algorithms on a rigorous foundation, showcasing their superiority over other methods.

Journal ArticleDOI
TL;DR: In this article, the authors present a comprehensive and in-depth overview on the recent advances, fundamental mechanisms, scientific challenges, and design strategies for the novel high-voltage electrolyte systems, especially focused on stability issues of the electrolytes, the compatibility and interactions between electrolytes and the electrodes, and reaction mechanisms.
Abstract: Since the advent of the Li ion batteries (LIBs), the energy density has been tripled, mainly attributed to the increase of the electrode capacities. Now, the capacity of transition metal oxide cathodes is approaching the limit due to the stability limitation of the electrolytes. To further promote the energy density of LIBs, the most promising strategies are to enhance the cut-off voltage of the prevailing cathodes or explore novel high-capacity and high-voltage cathode materials, and also replacing the graphite anode with Si/Si-C or Li metal. However, the commercial ethylene carbonate (EC)-based electrolytes with relatively low anodic stability of ∼4.3 V vs. Li+/Li cannot sustain high-voltage cathodes. The bottleneck restricting the electrochemical performance in Li batteries has veered towards new electrolyte compositions catering for aggressive next-generation cathodes and Si/Si-C or Li metal anodes, since the oxidation-resistance of the electrolytes and the in situ formed cathode electrolyte interphase (CEI) layers at the high-voltage cathodes and solid electrolyte interphase (SEI) layers on anodes critically control the electrochemical performance of these high-voltage Li batteries. In this review, we present a comprehensive and in-depth overview on the recent advances, fundamental mechanisms, scientific challenges, and design strategies for the novel high-voltage electrolyte systems, especially focused on stability issues of the electrolytes, the compatibility and interactions between the electrolytes and the electrodes, and reaction mechanisms. Finally, novel insights, promising directions and potential solutions for high voltage electrolytes associated with effective SEI/CEI layers are proposed to motivate revolutionary next-generation high-voltage Li battery chemistries.

Journal ArticleDOI
TL;DR: The concentrated additive strategy presented here provides a drop-in practical solution to further optimize carbonate electrolytes for beyond Li-ion batteries.
Abstract: In carbonate electrolytes, the organic-inorganic solid electrolyte interphase (SEI) formed on the Li-metal anode surface is strongly bonded to Li and experiences the same volume change as Li, thus it undergoes continuous cracking/reformation during plating/stripping cycles. Here, an inorganic-rich SEI is designed on a Li-metal surface to reduce its bonding energy with Li metal by dissolving 4m concentrated LiNO3 in dimethyl sulfoxide (DMSO) as an additive for a fluoroethylene-carbonate (FEC)-based electrolyte. Due to the aggregate structure of NO3 - ions and their participation in the primary Li+ solvation sheath, abundant Li2 O, Li3 N, and LiNx Oy grains are formed in the resulting SEI, in addition to the uniform LiF distribution from the reduction of PF6 - ions. The weak bonding of the SEI (high interface energy) to Li can effectively promote Li diffusion along the SEI/Li interface and prevent Li dendrite penetration into the SEI. As a result, our designed carbonate electrolyte enables a Li anode to achieve a high Li plating/stripping Coulombic efficiency of 99.55 % (1 mA cm-2 , 1.0 mAh cm-2 ) and the electrolyte also enables a Li||LiNi0.8 Co0.1 Mn0.1 O2 (NMC811) full cell (2.5 mAh cm-2 ) to retain 75 % of its initial capacity after 200 cycles with an outstanding CE of 99.83 %.

Journal ArticleDOI
TL;DR: In this article, the authors examined the relationship between cultural tightness and COVID-19 case and mortality rates as of Oct 16, 2020, using an ordinary least squares regression.

Journal ArticleDOI
TL;DR: The pivotal phase 2 results of ZUMA-3, an international, multicentre, single-arm, open-label study evaluating the efficacy and safety of the autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy KTE-X19 in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia remain poor, underlining the need for more effective therapies.

Journal ArticleDOI
Trygve E. Bakken1, Nikolas L. Jorstad1, Qiwen Hu2, Blue B. Lake3, Wei Tian4, Brian E. Kalmbach1, Brian E. Kalmbach5, Megan Crow6, Rebecca D. Hodge1, Fenna M. Krienen2, Staci A. Sorensen1, Jeroen Eggermont7, Zizhen Yao1, Brian D. Aevermann8, Andrew Aldridge4, Anna Bartlett4, Darren Bertagnolli1, Tamara Casper1, Rosa Castanon4, Kirsten Crichton1, Tanya L. Daigle1, Rachel A. Dalley1, Nick Dee1, Nikolai C. Dembrow9, Nikolai C. Dembrow5, Dinh Diep3, Songlin Ding1, Weixiu Dong3, Rongxin Fang3, Stephan Fischer6, Melissa Goldman2, Jeff Goldy1, Lucas T. Graybuck1, Brian R. Herb10, Xiaomeng Hou3, Jayaram Kancherla11, Matthew Kroll1, Kanan Lathia1, Baldur van Lew7, Yang Eric Li12, Yang Eric Li3, Christine S. Liu3, Christine S. Liu13, Hanqing Liu4, Jacinta Lucero4, Anup Mahurkar10, Delissa McMillen1, Jeremy A. Miller1, Marmar Moussa14, Joseph R. Nery4, Philip R. Nicovich1, Sheng-Yong Niu4, Sheng-Yong Niu3, Joshua Orvis10, Julia K. Osteen4, Scott F. Owen1, C. Palmer13, C. Palmer3, Thanh Pham1, Nongluk Plongthongkum3, Olivier Poirion3, Nora Reed2, Christine Rimorin1, Angeline Rivkin4, William J. Romanow13, Adriana E. Sedeno-Cortes1, Kimberly Siletti15, Saroja Somasundaram1, Josef Sulc1, Michael Tieu1, Amy Torkelson1, Herman Tung1, Xinxin Wang16, Fangming Xie3, Anna Marie Yanny1, Renee Zhang8, Seth A. Ament10, M. Margarita Behrens4, Héctor Corrada Bravo11, Jerold Chun13, Alexander Dobin6, Jesse Gillis6, Ronna Hertzano10, Patrick R. Hof17, Thomas Höllt18, Gregory D. Horwitz5, C. Dirk Keene5, Peter V. Kharchenko2, Andrew L. Ko19, Andrew L. Ko5, Boudewijn P. F. Lelieveldt18, Boudewijn P. F. Lelieveldt7, Chongyuan Luo20, Eran A. Mukamel3, Antonio Pinto-Duarte4, Sebastian Preissl3, Aviv Regev21, Bing Ren3, Bing Ren12, Richard H. Scheuermann3, Richard H. Scheuermann22, Richard H. Scheuermann8, Kimberly A. Smith1, William J. Spain9, William J. Spain5, Owen White10, Christof Koch1, Michael Hawrylycz1, Bosiljka Tasic1, Evan Z. Macosko21, Steven A. McCarroll21, Steven A. McCarroll2, Jonathan T. Ting5, Jonathan T. Ting1, Hongkui Zeng1, Kun Zhang3, Guoping Feng23, Guoping Feng21, Guoping Feng24, Joseph R. Ecker4, Sten Linnarsson15, Ed S. Lein1 
01 Oct 2021-Nature
TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.
Abstract: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals1. Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities that mirror evolutionary distance and are consistent between the transcriptome and epigenome. The core conserved molecular identities of neuronal and non-neuronal cell types allow us to generate a cross-species consensus classification of cell types, and to infer conserved properties of cell types across species. Despite the overall conservation, however, many species-dependent specializations are apparent, including differences in cell-type proportions, gene expression, DNA methylation and chromatin state. Few cell-type marker genes are conserved across species, revealing a short list of candidate genes and regulatory mechanisms that are responsible for conserved features of homologous cell types, such as the GABAergic chandelier cells. This consensus transcriptomic classification allows us to use patch-seq (a combination of whole-cell patch-clamp recordings, RNA sequencing and morphological characterization) to identify corticospinal Betz cells from layer 5 in non-human primates and humans, and to characterize their highly specialized physiology and anatomy. These findings highlight the robust molecular underpinnings of cell-type diversity in M1 across mammals, and point to the genes and regulatory pathways responsible for the functional identity of cell types and their species-specific adaptations.