Showing papers by "University of Massachusetts Amherst published in 2000"

A flat Universe from high-resolution maps of the cosmic microwave background radiation

Abstract: The blackbody radiation left over from the Big Bang has been transformed by the expansion of the Universe into the nearly isotropic 2.73 K cosmic microwave background. Tiny inhomogeneities in the early Universe left their imprint on the microwave background in the form of small anisotropies in its temperature. These anisotropies contain information about basic cosmological parameters, particularly the total energy density and curvature of the Universe. Here we report the first images of resolved structure in the microwave background anisotropies over a significant part of the sky. Maps at four frequencies clearly distinguish the microwave background from foreground emission. We compute the angular power spectrum of the microwave background, and find a peak at Legendre multipole l_(peak) = (197 ± 6), with an amplitude ΔT_(200) = (69 ± 8) µK. This is consistent with that expected for cold dark matter models in a flat (euclidean) Universe, as favoured by standard inflationary models.

Ultrahigh-Density Nanowire Arrays Grown in Self-Assembled Diblock Copolymer Templates

Abstract: We show a simple, robust, chemical route to the fabrication of ultrahigh-density arrays of nanopores with high aspect ratios using the equilibrium self-assembled morphology of asymmetric diblock copolymers. The dimensions and lateral density of the array are determined by segmental interactions and the copolymer molecular weight. Through direct current electrodeposition, we fabricated vertical arrays of nanowires with densities in excess of 1.9 x 10(11) wires per square centimeter. We found markedly enhanced coercivities with ferromagnetic cobalt nanowires that point toward a route to ultrahigh-density storage media. The copolymer approach described is practical, parallel, compatible with current lithographic processes, and amenable to multilayered device fabrication.

Ultrahydrophobic surfaces. Effects of topography length scales on wettability

Abstract: We discuss dynamic hydrophobicity from the perspective of the force required to move a water droplet on a surface and argue that the structure of the three-phase contact line is important. We studied the wettability of a series of silicon surfaces that were prepared by photolithography and hydrophobized using silanization reagents. Hydrocarbon, siloxane, and fluorocarbon surfaces were prepared. The surfaces contain posts of different sizes, shapes, and separations. Surfaces containing square posts with X−Y dimensions of 32 μm and less exhibited ultrahydrophobic behavior with high advancing and receding water contact angles. Water droplets moved very easily on these surfaces and rolled off of slightly tilted surfaces. Contact angles were independent of the post height from 20 to 140 μm and independent of surface chemistry. Water droplets were pinned on surfaces containing square posts with larger dimensions. Increasing the distance between posts and changing the shape of the posts from square to staggered ...

Attitudes and the Attitude-Behavior Relation: Reasoned and Automatic Processes

Abstract: The chapter re-examines, in light of recent developments, the reasoned action perspective inherent in the expectancy-value model of attitude and in the theory of planned behavior. According to this perspective, people's attitudes follow spontaneously and consistently from beliefs accessible in memory and then guide corresponding behavior. The number and types of beliefs that are accessible vary with motivation and ability to process attitude-relevant information and with the context. Based on these considerations, it is shown that the reasoned action perspective is compatible with evidence for automatic processes in the activation of attitudes and behavior, and with the finding that attitudes can vary with the context in which they are expressed. Implications for the attitude-behavior relation and for the role of habit in human behavior are discussed.

Fluid-based analysis of a network of AQM routers supporting TCP flows with an application to RED

Abstract: In this paper we use jump process driven Stochastic Differential Equations to model the interactions of a set of TCP flows and Active Queue Management routers in a network setting. We show how the SDEs can be transformed into a set of Ordinary Differential Equations which can be easily solved numerically. Our solution methodology scales well to a large number of flows. As an application, we model and solve a system where RED is the AQM policy. Our results show excellent agreement with those of similar networks simulated using the well known ns simulator. Our model enables us to get an in-depth understanding of the RED algorithm. Using the tools developed in this paper, we present a critical analysis of the RED algorithm. We explain the role played by the RED configuration parameters on the behavior of the algorithm in a network. We point out a flaw in the RED averaging mechanism which we believe is a cause of tuning problems for RED. We believe this modeling/solution methodology has a great potential in analyzing and understanding various network congestion control algorithms.

Lipid Oxidation in Oil-in-Water Emulsions: Impact of Molecular Environment on Chemical Reactions in Heterogeneous Food Systems

Abstract: The susceptibility of lipids to oxidation is a major cause of quality deterioration in food emulsions. The reaction mechanism and factors that influence oxidation are appreciably different for emulsified lipids than for bulk lipids. This article reviews the current understanding of the lipid oxidation mechanism in oil-in-water emulsions. It also discusses the major factors that influence the rate of lipid oxidation in emulsions, such as antioxidants, chelating agents, ingredient purity, ingredient partitioning, interfacial characteristics, droplet characteristics, and ingredient interactions. This knowledge is then used to define effective strategies for controlling lipid oxidation in food emulsions.

Modeling TCP Reno performance: a simple model and its empirical validation

Abstract: The steady-state performance of a bulk transfer TCP flow (i.e., a flow with a large amount of data to send, such as FTP transfers) may be characterized by the send rate, which is the amount of data sent by the sender in unit time. In this paper we develop a simple analytic characterization of the steady-state send rate as a function of loss rate and round trip time (RTT) for a bulk transfer TCP flow. Unlike the models of Lakshman and Madhow (see IEE/ACM Trans. Networking, vol.5, p.336-50, 1997), Mahdavi and Floyd (1997), Mathis, Semke, Mahdavi and Ott (see Comput. Commun. Rev., vol.27, no.3, 1997) and by by Ott et al., our model captures not only the behavior of the fast retransmit mechanism but also the effect of the time-out mechanism. Our measurements suggest that this latter behavior is important from a modeling perspective, as almost all of our TCP traces contained more time-out events than fast retransmit events. Our measurements demonstrate that our model is able to more accurately predict TCP send rate and is accurate over a wider range of loss rates. We also present a simple extension of our model to compute the throughput of a bulk transfer TCP flow, which is defined as the amount of data received by the receiver in unit time.

The complexity of decentralized control of Markov decision processes

Abstract: Planning for distributed agents with partial state information is considered from a decisiontheoretic perspective. We describe generalizations of both the MDP and POMDP models that allow for decentralized control. For even a small number of agents, the finite-horizon problems corresponding to both of our models are complete for nondeterministic exponential time. These complexity results illustrate a fundamental difference between centralized and decentralized control of Markov processes. In contrast to the MDP and POMDP problems, the problems we consider provably do not admit polynomialtime algorithms and most likely require doubly exponential time to solve in the worst case. We have thus provided mathematical evidence corresponding to the intuition that decentralized planning problems cannot easily be reduced to centralized problems and solved exactly using established techniques.

Self-assembly of nanoparticles into structured spherical and network aggregates

Abstract: Multi-scale ordering of materials is central for the application of molecular systems in macroscopic devices. Self-assembly based on selective control of non-covalent interactions provides a powerful tool for the creation of structured systems at a molecular level, and application of this methodology to macromolecular systems provides a means for extending such structures to macroscopic length scale. Monolayer-functionalized nanoparticles can be made with a wide variety of metallic and non-metallic cores, providing a versatile building block for such approaches. Here we present a polymer-mediated 'bricks and mortar' strategy for the ordering of nanoparticles into structured assemblies. This methodology allows monolayer-protected gold particles to self-assemble into structured aggregates while thermally controlling their size and morphology. Using 2-nm gold particles as building blocks, we show that spherical aggregates of size 97 +/- 17 nm can be produced at 23 degrees C, and that 0.5-1 microm spherical assemblies with (5-40) x 10(5) individual subunits form at -20 degrees C. Intriguingly, extended networks of approximately 50-nm subunits are formed at 10 degrees C, illustrating the potential of our approach for the formation of diverse structural motifs such as wires and rods. These findings demonstrate that the assembly process provides control over the resulting aggregates, while the modularity of the 'bricks and mortar' approach allows combinatorial control over the constituents, providing a versatile route to new materials systems.

The importance of repairing stalled replication forks

Abstract: The bacterial SOS response to unusual levels of DNA damage has been recognized and studied for several decades. Pathways for re-establishing inactivated replication forks under normal growth conditions have received far less attention. In bacteria growing aerobically in the absence of SOS-inducing conditions, many replication forks encounter DNA damage, leading to inactivation. The pathways for fork reactivation involve the homologous recombination systems, are nonmutagenic, and integrate almost every aspect of DNA metabolism. On a frequency-of-use basis, these pathways represent the main function of bacterial DNA recombination systems, as well as the main function of a number of other enzymatic systems that are associated with replication and site-specific recombination.

2MASS Extended Source Catalog: Overview and Algorithms

Abstract: The 2 Micron All-Sky Survey (2MASS)will observe over one-million galaxies and extended Galactic sources covering the entire sky at wavelenghts between 1 and 2 m. Most of these galaxies, from 70 to 80%, will be newly catalogued objetcs.

Validity of accelerometry for the assessment of moderate intensity physical activity in the field.

Abstract: HENDELMAN, D., K. MILLER, C. BAGGETT, E. DEBOLD, and P. FREEDSON. Validity of accelerometry for the assessment of moderate intensity physical activity in the field. Med. Sci. Sports Exerc., Vol. 32, No. 9, Suppl., pp. S442–S449, 2000.PurposeThis study was undertaken to examine the validity of accele

Invasiveness, invasibility and the role of environmental stress in the spread of non-native plants

Abstract: Invasion ecology, the study of how organisms spread in habitats to which they are not native, asks both about the invasiveness of species and the invasibility of habitats: Which species are most likely to become invasive? Which habitats are most susceptible to invasion? To set the stage for considering these questions with regard to plants, we offer a two-way classification of nativeness and invasiveness that distinguishes natives, non-invasive non-natives and invasive non-natives. We then consider the current state of knowledge about invasiveness and invasibility. Despite much investigation, it has proven difficult to identify traits that consistently predict invasiveness. This may be largely because different traits favour invasiveness in different habitats. It has proven easier to identify types of habitats that are relatively invasible, such as islands and riverbanks. Factors thought to render habitats invasible include low intensities of competition, altered disturbance regimes and low levels of environmental stress, especially high resource availability. These factors probably often interact; the combination of altered disturbance with high resource availability may particularly promote invasibility. When biotic factors control invasibility, non-natives that are unlike native species may prove more invasive; the converse may also be true. We end with a simple conceptual model for cases in which high levels of environmental stress should and should not reduce invasibility. In some cases, it may be possible to manipulate stress to control biological invasions by plants.

Electrically induced structure formation and pattern transfer

Abstract: The wavelength of light represents a fundamental technological barrier to the production of increasingly smaller features on integrated circuits. New technologies that allow the replication of patterns on scales less than 100 nm need to be developed if increases in computing power are to continue at the present rate. Here we report a simple electrostatic technique that creates and replicates lateral structures in polymer films on a submicrometre length scale. Our method is based on the fact that dielectric media experience a force in an electric field gradient. Strong field gradients can produce forces that overcome the surface tension in thin liquid films, inducing an instability that features a characteristic hexagonal order. In our experiments, pattern formation takes place in polymer films at elevated temperatures, and is fixed by cooling the sample to room temperature. The application of a laterally varying electric field causes the instability to be focused in the direction of the highest electric field. This results in the replication of a topographically structured electrode. We report patterns with lateral dimensions of 140 nm, but the extension of the technique to pattern replication on scales smaller than 100 nm seems feasible.

Genome sequence of Halobacterium species NRC-1

Abstract: We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into a large chromosome and 2 related minichromosomes. The Halobacterium NRC-1 genome codes for 2,630 predicted proteins, 36% of which are unrelated to any previously reported. Analysis of the genome sequence shows the presence of pathways for uptake and utilization of amino acids, active sodium-proton antiporter and potassium uptake systems, sophisticated photosensory and signal transduction pathways, and DNA replication, transcription, and translation systems resembling more complex eukaryotic organisms. Whole proteome comparisons show the definite archaeal nature of this halophile with additional similarities to the Gram-positive Bacillus subtilis and other bacteria. The ease of culturing Halobacterium and the availability of methods for its genetic manipulation in the laboratory, including construction of gene knockouts and replacements, indicate this halophile can serve as an excellent model system among the archaea.

Eligibility Traces for Off-Policy Policy Evaluation

Abstract: Eligibility traces have been shown to speed reinforcement learning, to make it more robust to hidden states, and to provide a link between Monte Carlo and temporal-difference methods. Here we generalize eligibility traces to off-policy learning, in which one learns about a policy different from the policy that generates the data. Off-policy methods can greatly multiply learning, as many policies can be learned about from the same data stream, and have been identified as particularly useful for learning about subgoals and temporally extended macro-actions. In this paper we consider the off-policy version of the policy evaluation problem, for which only one eligibility trace algorithm is known, a Monte Carlo method. We analyze and compare this and four new eligibility trace algorithms, emphasizing their relationships to the classical statistical technique known as importance sampling. Our main results are 1) to establish the consistency and bias properties of the new methods and 2) to empirically rank the new methods, showing improvement over one-step and Monte Carlo methods. Our results are restricted to model-free, table-lookup methods and to offline updating (at the end of each episode) although several of the algorithms could be applied more generally.

Nanoscopic Templates from Oriented Block Copolymer Films

Abstract: cylindrical microdomains, an orientation normal to the substrate surface is desirable. Two different approaches are used to this end. In thin films, random copolymers anchored to a substrate can be used to produce a neutral surface. [5] For entropic reasons, the microdomains orient normal to the substrate surface. [6] In a second approach, electric fields were used to orient the cylindrical microdomains parallel to the field lines. [7‐10] The approach relies on the orientation-dependent polarization energy induced when an anisotropic body is placed in an electric field. An anisotropic microphase structure will orient such that the interfaces between the two blocks are aligned parallel to the electric field. In this article it is shown that cylindrical microdomains of a copolymer film can be used to generate an array of ordered nanoscopic pores with well-controlled size, orientation, and structure. To this end, selective etching procedures and a characterization of the samples by quantitative analysis of the X-ray scattering along with electron (EM) and atomic force microscopies (AFM) are described. The processes outlined are shown to be operative over a very large range in sample thickness ranging from 40 nm up to several micrometers. The resulting nanoporous films are promising candidates as membranes with specific transport properties and as templates for electronic and magnetic nanostructured materials. Figures 1A and 1B show AFM images obtained from a

Placing Equity Front and Center Some Thoughts on Transforming Teacher Education for a New Century

Abstract: This article explores what it means for teacher education programs to place diversity front and center. Using a social justice perspective on teacher education, the author argues that schools and colleges of education need to radically transform their policies and practices if they are to become places where teachers and prospective teachers learn to become effective with students of all backgrounds in U.S. schools. Specifically, she suggests that teacher education programs need to take a stand on social justice and diversity, make social justice ubiquitous in teacher education, and promote teaching as a life-long journey of transformation. The author provides several examples of how to do this.

Improving the effectiveness of information retrieval with local context analysis

Abstract: Techniques for automatic query expansion have been extensively studied in information research as a means of addressing the word mismatch between queries and documents. These techniques can be categorized as either global or local. While global techniques rely on analysis of a whole collection to discover word relationships, local techniques emphasize analysis of the top-ranked documents retrieved for a query. While local techniques have shown to be more effective that global techniques in general, existing local techniques are not robust and can seriously hurt retrieved when few of the retrieval documents are relevant. We propose a new technique, called local context analysis, which selects expansion terms based on cooccurrence with the query terms within the top-ranked documents. Experiments on a number of collections, both English and non-English, show that local context analysis offers more effective and consistent retrieval results.

Self-Assembly Is Not the Only Reaction Possible between Alkyltrichlorosilanes and Surfaces: Monomolecular and Oligomeric Covalently Attached Layers of Dichloro- and Trichloroalkylsilanes on Silicon

Abstract: Silicon-supported alkylsiloxane layers were prepared by reaction of alkylmethyldichlorosilanes and alkyltrichlorosilanes with silicon wafers under two conditions: (1) in the vapor phase and (2) in toluene in the presence of ethyldiisopropylamine. Covalent attachment of di- and trichlorosilanes to the surface of silicon/silicon oxide through SiS−O−Si bonds occurs for the amine-catalyzed reactions. This sets apart this reaction from the self-assembly process that occurs in the reaction between certain trichlorosilanes and hydrated silica with no amine present. The thickness of the layers formed from dichloro- and trichlorosilanes (as assessed by ellipsometry) is on the order of the single molecule sizes and increases gradually with alkyl chain length. The thickness values are considerably smaller (by a factor of ∼0.75) than the length of the fully stretched alkyl chain, which argues for disordered structures of the monolayers. Dynamic advancing and receding contact angles for water, methylene iodide, and h...

Work and family in the 1990s

Abstract: This review highlights four themes emerging from the work and family literature of the 1990s. The first theme evolves from the historical legacy of the maternal employment literature with its focus on children's well-being. The second theme, work socialization, is based on the premise that occupational conditions, such as autonomy and complexity, shape the values of workers who in turn generalize these lessons off the job. Research on work stress, the third theme, explores how experiences of short- and long-term stress at work make their mark on workers' behavior and well-being off the job. Finally, the multiple roles literature focuses on how individuals balance roles, such as parent, spouse, and worker, and the consequences for health and family relationships. In addition to these four major themes, advances in work and family policy initiatives over the past decade are discussed. Suggestions for future research focus on addressing issues of causality, attending to the complexity of social contexts, linking research to policy, and developing interdisciplinary theories and research designs.

Rapid evolution of reproductive isolation in the wild: evidence from introduced salmon.

Abstract: Colonization of new environments should promote rapid speciation as a by-product of adaptation to divergent selective regimes. Although this process of ecological speciation is known to have occurred over millennia or centuries, nothing is known about how quickly reproductive isolation actually evolves when new environments are first colonized. Using DNA microsatellites, population-specific natural tags, and phenotypic variation, we tested for reproductive isolation between two adjacent salmon populations of a common ancestry that colonized divergent reproductive environments (a river and a lake beach). We found evidence for the evolution of reproductive isolation after fewer than 13 generations.

Genetic Requirements for Inheritance of RNAi in C. elegans

Abstract: In Caenorhabditis elegans, the introduction of double-stranded RNA triggers sequence-specific genetic interference (RNAi) that is transmitted to offspring. The inheritance properties associated with this phenomenon were examined. Transmission of the interference effect occurred through a dominant extragenic agent. The wild-type activities of the RNAi pathway genes rde-1 andrde-4 were required for the formation of this interfering agent but were not needed for interference thereafter. In contrast, therde-2 and mut-7 genes were required downstream for interference. These findings provide evidence for germ line transmission of an extragenic sequence-specific silencing factor and implicate rde-1 and rde-4 in the formation of the inherited agent.

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

Abstract: An expansion of polyglutamines in the N terminus of huntingtin causes Huntington's disease (HD) and results in the accrual of mutant protein in the nucleus and cytoplasm of affected neurons. How mutant huntingtin causes neurons to die is unclear, but some recent observations suggest that an autophagic process may occur. We showed previously that huntingtin markedly accumulates in endosomal–lysosomal organelles of affected HD neurons and, when exogenously expressed in clonal striatal neurons, huntingtin appears in cytoplasmic vacuoles causing cells to shrink. Here we show that the huntingtin-enriched cytoplasmic vacuoles formed in vitro internalized the lysosomal enzyme cathepsin D in proportion to the polyglutamine-length in huntingtin. Huntingtin-labeled vacuoles displayed the ultrastructural features of early and late autophagosomes (autolysosomes), had little or no overlap with ubiquitin, proteasome, and heat shock protein 70/heat shock cognate 70 immunoreactivities, and altered the arrangement of Golgi membranes, mitochondria, and nuclear membranes. Neurons with excess cytoplasmic huntingtin also exhibited increased tubulation of endosomal membranes. Exogenously expressed human full-length wild-type and mutant huntingtin codistributed with endogenous mouse huntingtin in soluble and membrane fractions, whereas human N-terminal huntingtin products were found only in membrane fractions that contained lysosomal organelles. We speculate that mutant huntingtin accumulation in HD activates the endosomal–lysosomal system, which contributes to huntingtin proteolysis and to an autophagic process of cell death.