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Showing papers by "University of Massachusetts Amherst published in 2002"


Journal ArticleDOI
TL;DR: In this article, it is shown that perceived behavioral control over performance of a behavior, though comprised of separable components that reflect beliefs about self-efficacy and about controllability, can nevertheless be considered a unitary latent variable in a hierarchical factor model.
Abstract: Conceptual and methodological ambiguities surrounding the concept of perceived behavioral control are clarified. It is shown that perceived control over performance of a behavior, though comprised of separable components that reflect beliefs about self-efficacy and about controllability, can nevertheless be considered a unitary latent variable in a hierarchical factor model. It is further argued that there is no necessary correspondence between self-efficacy and internal control factors, or between controllability and external control factors. Self-efficacy and controllability can reflect internal as well as external factors and the extent to which they reflect one or the other is an empirical question. Finally, a case is made that measures of perceived behavioral control need to incorporate self-efficacy as well as controllability items that are carefully selected to ensure high internal consistency. Summary and Conclusions Perceived control over performance of a behavior can account for consider- able variance in intentions and actions. However, ambiguities surrounding the concept of perceived behavioral control have tended to create uncertainties and to impede progress. The present article attempted to clarify conceptual ambiguities and resolve issues related to the operationalization of perceived behavioral control. Recent research has demonstrated that the overarching concept of perceived behavioral control, as commonly assessed, is comprised of two components: self-efficacy (dealing largely with the ease or difficulty of performing a behavior) and controllability (the extent to which performance is up to the actor). Contrary to a widely accepted view, it was argued that self-efficacy expectations do not necessarily correspond to beliefs about internal control factors, and that controllability expectations have no necessary basis in the perceived operation of external factors. Instead, it was suggested that self-efficacy and controllability may both reflect beliefs about the presence of internal as well as external factors. Rather than making a priori assumptions about the internal or external locus of self-efficacy and controllability, this issue is best treated as an empirical question. Also of theoretical significance, the present article tried to dispel the notion that self-efficacy and controllability are incompatible with, or independent of, each other. Although factor analyses of perceived behavioral control items provide clear and consistent evidence for the distinction, there is sufficient commonality between self-efficacy and controllability to suggest a two-level hierarchical model. In this model, perceived behavioral control is the overarching, superordinate construct that is comprised of two lower-level components: self-efficacy and controllability. This view of the control component in the theory of planned behavior implies that measures of perceived behavioral control should contain items that assess self-efficacy as well as controllability. Depending on the purpose of the investigation, a decision can be made to aggregate over all items, treating perceived behavioral control as a unitary factor, or to distinguish between self-efficacy and controllability by entering separate indices into the prediction equation.

6,544 citations


Journal ArticleDOI
03 Jan 2002-Nature
TL;DR: It is suggested that p53 has a role in regulating organismal ageing by generating mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment.
Abstract: The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than inactivated p53. Mutant (p53+/m) mice exhibit enhanced resistance to spontaneous tumours compared with wild-type (p53+/+) littermates. As p53+/m mice age, they display an early onset of phenotypes associated with ageing. These include reduced longevity, osteoporosis, generalized organ atrophy and a diminished stress tolerance. A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing.

1,387 citations


Journal ArticleDOI
18 Jan 2002-Science
TL;DR: A specific enrichment of microorganisms of the family Geobacteraceae is reported on energy-harvesting anodes, and it is shown that these microorganisms can conserve energy to support their growth by oxidizing organic compounds with an electrode serving as the sole electron acceptor.
Abstract: Energy in the form of electricity can be harvested from marine sediments by placing a graphite electrode (the anode) in the anoxic zone and connecting it to a graphite cathode in the overlying aerobic water. We report a specific enrichment of microorganisms of the family Geobacteraceae on energy-harvesting anodes, and we show that these microorganisms can conserve energy to support their growth by oxidizing organic compounds with an electrode serving as the sole electron acceptor. This finding not only provides a method for extracting energy from organic matter, but also suggests a strategy for promoting the bioremediation of organic contaminants in subsurface environments.

1,356 citations


Journal ArticleDOI
TL;DR: Research using human studies suggests that there is either no difference between men and women or that women are more prone to exercise-induced muscle damage than are men, and there is controversy concerning the presence of sex differences in the response of muscle to damage-inducing exercise.
Abstract: Exercise-induced muscle injury in humans frequently occurs after unaccustomed exercise, particularly if the exercise involves a large amount of eccentric (muscle lengthening) contractions. Direct measures of exercise-induced muscle damage include cellular and subcellular disturbances, particularly Z-line streaming. Several indirectly assessed markers of muscle damage after exercise include increases in T2 signal intensity via magnetic resonance imaging techniques, prolonged decreases in force production measured during both voluntary and electrically stimulated contractions (particularly at low stimulation frequencies), increases in inflammatory markers both within the injured muscle and in the blood, increased appearance of muscle proteins in the blood, and muscular soreness. Although the exact mechanisms to explain these changes have not been delineated, the initial injury is ascribed to mechanical disruption of the fiber, and subsequent damage is linked to inflammatory processes and to changes in excitation-contraction coupling within the muscle. Performance of one bout of eccentric exercise induces an adaptation such that the muscle is less vulnerable to a subsequent bout of eccentric exercise. Although several theories have been proposed to explain this "repeated bout effect," including altered motor unit recruitment, an increase in sarcomeres in series, a blunted inflammatory response, and a reduction in stress-susceptible fibers, there is no general agreement as to its cause. In addition, there is controversy concerning the presence of sex differences in the response of muscle to damage-inducing exercise. In contrast to the animal literature, which clearly shows that females experience less damage than males, research using human studies suggests that there is either no difference between men and women or that women are more prone to exercise-induced muscle damage than are men.

1,294 citations


Journal ArticleDOI
TL;DR: In this paper, a review of existing evidence suggests that the residual impact of past behavior is attenuated when measures of intention and behavior are compatible and vanishes when intentions are strong and well formed, expectations are implemented.
Abstract: The frequency with which a behavior has been performed in the past is found to account for variance in later behavior independent of intentions. This often taken as evidence for habituation of behavior and as complementing the reasoned mode of operation assumed by such models as the theory of planned behavior. In this article, I question the idea that the residual effect of past on later behavior can be attributed to habituation. The habituation perspective cannot account for residual effects in the prediction of low-opportunity behaviors performed in unstable contexts, no accepted independent measure of habit is available, and empirical tests of them habituation hypothesis have so far met with little success. A review of existing evidence suggests that the residual impact of past behavior is attenuated when measures of intention and behavior are compatible and vanishes when intentions are strong and well formed, expectations are implementation have been developed.

1,181 citations


Journal ArticleDOI
TL;DR: The authors argue that community governance addresses some common market and state failures but typically relies on insider-outsider distinctions that may be morally repugnant and economically costly, and the individual motivations supporting community governance are not captured by either selfishness or altruism.
Abstract: Community governance is the set of small group social interactions that, with market and state, determine economic outcomes. We argue (i) community governance addresses some common market and state failures but typically relies on insider-outsider distinctions that may be morally repugnant and economically costly; (ii) the individual motivations supporting community governance are not captured by either selfishness or altruism; (iii) communities, markets and states are complements, not substitutes; (iv) when poorly designed, markets and states crowd out communities; (v) some distributions of property rights are better than others at fostering community governance; and (vi) communities will probably increase in importance in the future.

1,042 citations


Journal ArticleDOI
TL;DR: It is shown that proteins containing azidohomoalanine can be selectively modified in the presence of other cellular proteins by means of Staudinger ligation with triarylphosphine reagents and incorporation of azide-functionalized amino acids into proteins in vivo provides opportunities for protein modification under native conditions and selective labeling of proteins in the intracellular environment.
Abstract: The introduction of chemically unique groups into proteins by means of non-natural amino acids has numerous applications in protein engineering and functional studies. One method to achieve this involves the utilization of a non-natural amino acid by the cell's native translational apparatus. Here we demonstrate that a methionine surrogate, azidohomoalanine, is activated by the methionyl-tRNA synthetase of Escherichia coli and replaces methionine in proteins expressed in methionine-depleted bacterial cultures. We further show that proteins containing azidohomoalanine can be selectively modified in the presence of other cellular proteins by means of Staudinger ligation with triarylphosphine reagents. Incorporation of azide-functionalized amino acids into proteins in vivo provides opportunities for protein modification under native conditions and selective labeling of proteins in the intracellular environment.

964 citations


Journal ArticleDOI
TL;DR: The standardize a polyvinyl chloride microtiter plate assay can be used as a rapid, simple method to screen for differences in biofilm production between strains or growth conditions prior to performing labor-intensive microscopic analyses.
Abstract: Listeria monocytogenes has the ability to form biofilms on food-processing surfaces, potentially leading to food product contamination. The objective of this research was to standardize a polyvinyl chloride (PVC) microtiter plate assay to compare the ability of L. monocytogenes strains to form biofilms. A total of 31 coded L. monocytogenes strains were grown in defined medium (modified Welshimer's broth) at 32°C for 20 and 40 h in PVC microtiter plate wells. Biofilm formation was indirectly assessed by staining with 1% crystal violet and measuring crystal violet absorbance, using destaining solution. Cellular growth rates and final cell densities did not correlate with biofilm formation, indicating that differences in biofilm formation under the same environmental conditions were not due to growth rate differences. The mean biofilm production of lineage I strains was significantly greater than that observed for lineage II and lineage III strains. The results from the standardized microtiter plate biofilm assay were also compared to biofilm formation on PVC and stainless steel as assayed by quantitative epifluorescence microscopy. Results showed similar trends for the microscopic and microtiter plate assays, indicating that the PVC microtiter plate assay can be used as a rapid, simple method to screen for differences in biofilm production between strains or growth conditions prior to performing labor-intensive microscopic analyses.

924 citations


Journal ArticleDOI
TL;DR: In this article, the authors proposed a block-iterative version of the split feasibility problem (SFP) called the CQ algorithm, which involves only the orthogonal projections onto C and Q, which we shall assume are easily calculated, and involves no matrix inverses.
Abstract: Let C and Q be nonempty closed convex sets in R N and R M , respectively, and A an M by N real matrix. The split feasibility problem (SFP) is to find x ∈ C with Ax ∈ Q ,i f suchx exist. An iterative method for solving the SFP, called the CQ algorithm, has the following iterative step: x k+1 = PC (x k + γ A T (PQ − I )Ax k ), where γ ∈ (0, 2/L) with L the largest eigenvalue of the matrix A T A and PC and PQ denote the orthogonal projections onto C and Q, respectively; that is, PC x minimizesc − x� ,o ver allc ∈ C.T heCQ algorithm converges to a solution of the SFP, or, more generally, to a minimizer ofPQ Ac − Acover c in C, whenever such exist. The CQ algorithm involves only the orthogonal projections onto C and Q, which we shall assume are easily calculated, and involves no matrix inverses. If A is normalized so that each row has length one, then L does not exceed the maximum number of nonzero entries in any column of A, which provides a helpful estimate of L for sparse matrices. Particular cases of the CQ algorithm are the Landweber and projected Landweber methods for obtaining exact or approximate solutions of the linear equations Ax = b ;t healgebraic reconstruction technique of Gordon, Bender and Herman is a particular case of a block-iterative version of the CQ algorithm. One application of the CQ algorithm that is the subject of ongoing work is dynamic emission tomographic image reconstruction, in which the vector x is the concatenation of several images corresponding to successive discrete times. The matrix A and the set Q can then be selected to impose constraints on the behaviour over time of the intensities at fixed voxels, as well as to require consistency (or near consistency) with measured data.

884 citations


Book
01 Jan 2002
TL;DR: This collection of technical papers from leading researchers in the field not only provides several chapters devoted to the research program and its evaluation paradigm, but also presents the most current research results and describes some of the remaining open challenges.
Abstract: Topic Detection and Tracking: Event-based Information Organization brings together in one place state-of-the-art research in Topic Detection and Tracking (TDT). This collection of technical papers from leading researchers in the field not only provides several chapters devoted to the research program and its evaluation paradigm, but also presents the most current research results and describes some of the remaining open challenges. Topic Detection and Tracking: Event-based Information Organization is an excellent reference for researchers and practitioners in a variety of fields related to TDT, including information retrieval, automatic speech recognition, machine learning, and information extraction

872 citations


Journal ArticleDOI
TL;DR: A recently developed dynamic model of TCP congestion-avoidance mode relates key network parameters such as the number of TCP sessions, link capacity and round-trip time to the underlying feedback control problem and analyzes the present de facto AQM standard: random early detection (RED) and determines that REDs queue-averaging is not beneficial.
Abstract: In active queue management (AQM), core routers signal transmission control protocol (TCP) sources with the objective of managing queue utilization and delay. It is essentially a feedback control problem. Based on a recently developed dynamic model of TCP congestion-avoidance mode, this paper does three things: 1) it relates key network parameters such as the number of TCP sessions, link capacity and round-trip time to the underlying feedback control problem; 2) it analyzes the present de facto AQM standard: random early detection (RED) and determines that REDs queue-averaging is not beneficial; and 3) it recommends alternative AQM schemes which amount to classical proportional and proportional-integral control. We illustrate our results using ns simulations and demonstrate the practical impact of proportional-integral control on managing queue utilization and delay.

Journal ArticleDOI
TL;DR: A core (sub)set of metrics are proposed, identified through literature reviews, which are understood as the most useful and relevant for landscape planning, and a two-part sustainable landscape planning perspective is proposed, integrating horizontal and vertical perspectives.

Journal ArticleDOI
TL;DR: The diverse toxic actions and pharmacological effects of pyrethroids suggest that simple additivity models based on combined actions at a single target are not appropriate to assess the risks of cumulative exposure to multiple pyre Throids.

Proceedings ArticleDOI
18 Nov 2002
TL;DR: This paper provides a careful analysis of Code Red propagation by accounting for two factors: one is the dynamic countermeasures taken by ISPs and users; the other is the slowed down worm infection rate because Code Red rampant propagation caused congestion and troubles to some routers.
Abstract: The Code Red worm incident of July 2001 has stimulated activities to model and analyze Internet worm propagation. In this paper we provide a careful analysis of Code Red propagation by accounting for two factors: one is the dynamic countermeasures taken by ISPs and users; the other is the slowed down worm infection rate because Code Red rampant propagation caused congestion and troubles to some routers. Based on the classical epidemic Kermack-Mckendrick model, we derive a general Internet worm model called the two-factor worm model. Simulations and numerical solutions of the two-factor worm model match the observed data of Code Red worm better than previous models do. This model leads to a better understanding and prediction of the scale and speed of Internet worm spreading.

Journal ArticleDOI
Bernard Aubert, A. Bazan, A. Boucham, D. Boutigny  +816 moreInstitutions (68)
TL;DR: BABAR as discussed by the authors is a detector for the SLAC PEP-II asymmetric e+e-B Factory operating at the upsilon 4S resonance, which allows comprehensive studies of CP-violation in B-meson decays.
Abstract: BABAR, the detector for the SLAC PEP-II asymmetric e+e- B Factory operating at the upsilon 4S resonance, was designed to allow comprehensive studies of CP-violation in B-meson decays. Charged particle tracks are measured in a multi-layer silicon vertex tracker surrounded by a cylindrical wire drift chamber. Electromagentic showers from electrons and photons are detected in an array of CsI crystals located just inside the solenoidal coil of a superconducting magnet. Muons and neutral hadrons are identified by arrays of resistive plate chambers inserted into gaps in the steel flux return of the magnet. Charged hadrons are identified by dE/dx measurements in the tracking detectors and in a ring-imaging Cherenkov detector surrounding the drift chamber. The trigger, data acquisition and data-monitoring systems, VME- and network-based, are controlled by custom-designed online software. Details of the layout and performance of the detector components and their associated electronics and software are presented.

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the link between submarine volcanism, plankton evolution, and the cycling of carbon through the marine biosphere, and concluded that there were important linkages between submarine volcano activity and marine productivity.
Abstract: [1] Mid-Cretaceous (Barremian-Turonian) plankton preserved in deep-sea marl, organic-rich shale, and pelagic carbonate hold an important record of how the marine biosphere responded to short- and long-term changes in the ocean-climate system. Oceanic anoxic events (OAEs) were short-lived episodes of organic carbon burial that are distinguished by their widespread distribution as discrete beds of black shale and/or pronounced carbon isotopic excursions. OAE1a in the early Aptian (∼120.5 Ma) and OAE2 at the Cenomanian/Turonian boundary (∼93.5 Ma) were global in their distribution and associated with heightened marine productivity. OAE1b spans the Aptian/Albian boundary (∼113–109 Ma) and represents a protracted interval of dysoxia with multiple discrete black shales across parts of Tethys (including Mexico), while OAE1d developed across eastern and western Tethys and in other locales during the latest Albian (∼99.5 Ma). Mineralized plankton experienced accelerated rates of speciation and extinction at or near the major Cretaceous OAEs, and strontium isotopic evidence suggests a possible link to times of rapid oceanic plateau formation and/or increased rates of ridge crest volcanism. Elevated levels of trace metals in OAE1a and OAE2 strata suggest that marine productivity may have been facilitated by increased availability of dissolved iron. The association of plankton turnover and carbon isotopic excursions with each of the major OAEs, despite the variable geographic distribution of black shale accumulation, points to widespread changes in the ocean-climate system. Ocean crust production and hydrothermal activity increased in the late Aptian. Faster spreading rates [and/or increased ridge length] drove a long-term (Albian–early Turonian) rise in sea level and CO2-induced global warming. Changes in ocean circulation, water column stratification, and nutrient partitioning lead to a reorganization of plankton community structure and widespread carbonate (chalk) deposition during the Late Cretaceous. We conclude that there were important linkages between submarine volcanism, plankton evolution, and the cycling of carbon through the marine biosphere.

Journal ArticleDOI
18 Oct 2002-Science
TL;DR: Variable deposition of F– and Na+during the African Humid Period suggests rapidly fluctuating lake levels between ∼11.7 and 4 ka, which is coincident with the “First Dark Age,” the period of the greatest historically recorded drought in tropical Africa.
Abstract: Six ice cores from Kilimanjaro provide an ∼11.7-thousand-year record of Holocene climate and environmental variability for eastern equatorial Africa, including three periods of abrupt climate change: ∼8.3, ∼5.2, and ∼4 thousand years ago (ka). The latter is coincident with the “First Dark Age,” the period of the greatest historically recorded drought in tropical Africa. Variable deposition of F – and Na + during the African Humid Period suggests rapidly fluctuating lake levels between ∼11.7 and 4 ka. Over the 20th century, the areal extent of Kilimanjaro9s ice fields has decreased ∼80%, and if current climatological conditions persist, the remaining ice fields are likely to disappear between 2015 and 2020.

Proceedings ArticleDOI
11 Aug 2002
TL;DR: It is suggested that clarity scores measure the ambiguity of a query with respect to a collection of documents and show that they correlate positively with average precision in a variety of TREC test sets.
Abstract: We develop a method for predicting query performance by computing the relative entropy between a query language model and the corresponding collection language model. The resulting clarity score measures the coherence of the language usage in documents whose models are likely to generate the query. We suggest that clarity scores measure the ambiguity of a query with respect to a collection of documents and show that they correlate positively with average precision in a variety of TREC test sets. Thus, the clarity score may be used to identify ineffective queries, on average, without relevance information. We develop an algorithm for automatically setting the clarity score threshold between predicted poorly-performing queries and acceptable queries and validate it using TREC data. In particular, we compare the automatic thresholds to optimum thresholds and also check how frequently results as good are achieved in sampling experiments that randomly assign queries to the two classes.

Journal ArticleDOI
TL;DR: These results demonstrate in real marine environments a new form of power generation that uses an immense, renewable energy reservoir (sedimentary organic carbon) and has near-immediate application.
Abstract: In many marine environments, a voltage gradient exists across the water‐sediment interface resulting from sedimentary microbial activity. Here we show that a fuel cell consisting of an anode embedded in marine sediment and a cathode in overlying seawater can use this voltage gradient to generate electrical power in situ. Fuel cells of this design generated sustained power in a boat basin carved into a salt marsh near Tuckerton, New Jersey, and in the Yaquina Bay Estuary near Newport, Oregon. Retrieval and analysis of the Tuckerton fuel cell indicates that power generation results from at least two anode reactions: oxidation of sediment sulfide (a by-product of microbial oxidation of sedimentary organic carbon) and oxidation of sedimentary organic carbon catalyzed by microorganisms colonizing the anode. These results demonstrate in real marine environments a new form of power generation that uses an immense, renewable energy reservoir (sedimentary organic carbon) and has near-immediate application.

Journal ArticleDOI
TL;DR: It is evident that most manipulative and mensurative fragmentation experiments have not provided clear insights into the ecological mechanisms and effects of habitat fragmentation, and recommendations for improving the design and implementation of fragmentation experiments are concluded.
Abstract: Ecologists have used a variety of comparative mensurative and manipulative experimental approaches to study the biological consequences of habitat fragmentation. In this paper, we evaluate the merits of the two major approaches and offer guidelines for selecting a design. Manipulative experiments rigorously assess fragmentation effects by comparing pre- and post-treatment conditions. Yet they are often constrained by a number of practical limitations, such as the difficulty in implementing large-scale treatments and the impracticality of measuring the long-term (decades to centuries) responses to the imposed treatments. Comparative mensurative studies generally involve substituting space for time, and without pre-treatment control, can be constrained by variability in ecological characteristics among different landscapes. These confounding effects can seriously limit the strength of inferences. Depending on the scale of the study system and how “landscape” is defined, both approaches may be limited by the difficulty of replicating at the landscape scale. Overall, both mensurative and manipulative approaches have merit and can contribute to the body of knowledge on fragmentation. However, from our review of 134 fragmentation studies published recently in three major ecological journals, it is evident that most manipulative and mensurative fragmentation experiments have not provided clear insights into the ecological mechanisms and effects of habitat fragmentation. We discuss the reasons for this and conclude with recommendations for improving the design and implementation of fragmentation experiments.

Journal ArticleDOI
TL;DR: This article examined whether there has been a corresponding change in men's and women's stereotypes of managers such that less emphasis is placed on managers' possessing masculine characteristics, and found that although managerial stereotypes place less emphasis on masculine characteristics than in earlier studies, a good manager is still perceived as predominantly masculine.

Journal ArticleDOI
TL;DR: It is shown that oncogenic Ras activates Notch signaling and that wild-type Notch-1 is necessary to maintain the neoplastic phenotype in Ras-transformed human cells in vitro and in vivo and suggests that it might be a novel therapeutic target.
Abstract: Truncated Notch receptors have transforming activity in vitro and in vivo. However, the role of wild-type Notch signaling in neoplastic transformation remains unclear. Ras signaling is deregulated in a large fraction of human malignancies and is a major target for the development of novel cancer treatments. We show that oncogenic Ras activates Notch signaling and that wild-type Notch-1 is necessary to maintain the neoplastic phenotype in Ras-transformed human cells in vitro and in vivo. Oncogenic Ras increases levels and activity of the intracellular form of wild-type Notch-1, and upregulates Notch ligand Delta-1 and also presenilin-1, a protein involved in Notch processing, through a p38-mediated pathway. These observations place Notch signaling among key downstream effectors of oncogenic Ras and suggest that it might be a novel therapeutic target.

Journal ArticleDOI
TL;DR: In this article, the integration of acceptance-based treatments with existing cognitive-behavioral treatments for generalized anxiety disorder (CAD) has been discussed and a new treatment stemming from this conceptual integration is described.
Abstract: Generalized anxiety disorder (CAD) is a chronic, pervasive disorder for which we have yet to develop sufficiently efficacious interventions. In this article we propose that recent research and theory regarding this disorder supports the integration of acceptance-based treatments with existing cognitive-behavioral treatments for CAD to improve the efficacy and clinical significance of such approaches. The bases for this proposal (from both the CAD and the acceptance-based treatment literature) are reviewed, and a new treatment stemming from this conceptual integration is described.

Journal ArticleDOI
TL;DR: Recently, the authors of as discussed by the authors have shown that the contribution of schooling to cognitive development plays little part in explaining why those with more schooling have higher earnings, while personality traits, rather than skills, are determinants of labor market success.
Abstract: Recent research has entirely vindicated the authors' once-controversial estimates of high levels of intergenerational persistence of economic status, the unimportance of the heritability of IQ in this process, and the fact that the contribution of schooling to cognitive development plays little part in explaining why those with more schooling have higher earnings. Additional research has supported the authors' hypotheses concerning the role of personality traits, rather than skills, per se, as determinants of labor market success. Recent contributions to the study of cultural evolution allow the authors to be considerably more specific about how behaviors are learned in school

Journal ArticleDOI
TL;DR: After interferon-γ treatment, which causes proteasomes to produce more NH2-extended antigenic precursors, ERAP1 increased the supply of peptides for MHC class I antigen presentation and trimmed nearly half the nine-residue peptides tested.
Abstract: Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) appears to be specialized to produce peptides presented on class I major histocompatibility complex molecules. We found that purified ERAP1 trimmed peptides that were ten residues or longer, but spared eight-residue peptides. In vivo, ERAP1 enhanced production of an eight-residue ovalbumin epitope from precursors extended on the NH2 terminus that were generated either in the ER or cytosol. Purified ERAP1 also trimmed nearly half the nine-residue peptides tested. By destroying such nine-residue peptides in normal human cells, ERAP1 reduced the overall supply of antigenic peptides. However, after interferon-γ treatment, which causes proteasomes to produce more NH2-extended antigenic precursors, ERAP1 increased the supply of peptides for MHC class I antigen presentation.

Journal ArticleDOI
TL;DR: The results show that sex chromosome genes contribute directly to the development of a sex difference in the brain.
Abstract: We tested the hypothesis that genes encoded on the sex chromosomes play a direct role in sexual differentiation of brain and behavior. We used mice in which the testis-determining gene (Sry) was moved from the Y chromosome to an autosome (by deletion of Sry from the Y and subsequent insertion of an Sry transgene onto an autosome), so that the determination of testis development occurred independently of the complement of X or Y chromosomes. We compared XX and XY mice with ovaries (females) and XX and XY mice with testes (males). These comparisons allowed us to assess the effect of sex chromosome complement (XX vs XY) independent of gonadal status (testes vs ovaries) on sexually dimorphic neural and behavioral phenotypes. The phenotypes included measures of male copulatory behavior, social exploration behavior, and sexually dimorphic neuroanatomical structures in the septum, hypothalamus, and lumbar spinal cord. Most of the sexually dimorphic phenotypes correlated with the presence of ovaries or testes and therefore reflect the hormonal output of the gonads. We found, however, that both male and female mice with XY sex chromosomes were more masculine than XX mice in the density of vasopressin-immunoreactive fibers in the lateral septum. Moreover, two male groups differing only in the form of their Sry gene showed differences in behavior. The results show that sex chromosome genes contribute directly to the development of a sex difference in the brain.

Journal ArticleDOI
TL;DR: The SLEUTH model is a cellular automaton model with predefined growth rules applied spatially to gridded maps of the cities in a set of nested loops, and was designed to be both scaleable and universally applicable as discussed by the authors.

Journal ArticleDOI
TL;DR: The method represents gene-expression dynamics as autoregressive equations and uses an agglomerative procedure to search for the most probable set of clusters given the available data and acquires an independent, principled measure to decide when two series are different enough to belong to different clusters.
Abstract: This article presents a Bayesian method for model-based clustering of gene expression dynamics. The method represents gene-expression dynamics as autoregressive equations and uses an agglomerative procedure to search for the most probable set of clusters given the available data. The main contributions of this approach are the ability to take into account the dynamic nature of gene expression time series during clustering and a principled way to identify the number of distinct clusters. As the number of possible clustering models grows exponentially with the number of observed time series, we have devised a distance-based heuristic search procedure able to render the search process feasible. In this way, the method retains the important visualization capability of traditional distance-based clustering and acquires an independent, principled measure to decide when two series are different enough to belong to different clusters. The reliance of this method on an explicit statistical representation of gene expression dynamics makes it possible to use standard statistical techniques to assess the goodness of fit of the resulting model and validate the underlying assumptions. A set of gene-expression time series, collected to study the response of human fibroblasts to serum, is used to identify the properties of the method.

Journal ArticleDOI
TL;DR: Care work pays less than other occupations after controlling for the education and employment experience of the workers, many occupation and industry characteristics, and (via individual fixed effects) unmeasured, stable characteristics of those who hold the jobs.
Abstract: We examine the relative pay of occupations involving care, such as teaching, counseling, providing health services, or supervising children. We use panel data from the National Longitudinal Survey of Youth covering workers between 17 and 35 years of age. Care work pays less than other occupations after controlling for the education and employment experience of the workers, many occupation and industry characteristics, and (via individual fixed effects) unmeasured, stable characteristics of those who hold the jobs. Both men and women in care work pay this relative wage penalty. However, more women than men pay the penalty, since more women than men do this kind of work.

Proceedings Article
07 Aug 2002
TL;DR: In this article, an efficient feature induction method for CRFs is presented, based on the principle of iteratively constructing feature conjunctions that would significantly increase conditional log-likelihood if added to the model.
Abstract: Conditional Random Fields (CRFs) are undirected graphical models, a special case of which correspond to conditionally-trained finite state machines. A key advantage of CRFs is their great flexibility to include a wide variety of arbitrary, non-independent features of the input. Faced with this freedom, however, an important question remains: what features should be used? This paper presents an efficient feature induction method for CRFs. The method is founded on the principle of iteratively constructing feature conjunctions that would significantly increase conditional log-likelihood if added to the model. Automated feature induction enables not only improved accuracy and dramatic reduction in parameter count, but also the use of larger cliques, and more freedom to liberally hypothesize atomic input variables that may be relevant to a task. The method applies to linear-chain CRFs, as well as to more arbitrary CRF structures, such as Relational Markov Networks, where it corresponds to learning clique templates, and can also be understood as supervised structure learning. Experimental results on named entity extraction and noun phrase segmentation tasks are presented.