Showing papers by "University of Massachusetts Amherst published in 2009"

Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities

Abstract: mothur aims to be a comprehensive software package that allows users to use a single piece of software to analyze community sequence data. It builds upon previous tools to provide a flexible and powerful software package for analyzing sequencing data. As a case study, we used mothur to trim, screen, and align sequences; calculate distances; assign sequences to operational taxonomic units; and describe the alpha and beta diversity of eight marine samples previously characterized by pyrosequencing of 16S rRNA gene fragments. This analysis of more than 222,000 sequences was completed in less than 2 h with a laptop computer.

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

Abstract: Thereisgrowinginterestinthepossiblehealththreatposedbyendocrine-disruptingchemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction. In this first Scientific Statement of The Endocrine Society, we present the evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology. Results from animal models, human clinical observations, and epidemiological studies converge to implicate EDCs as a significant concern to public health. The mechanisms of EDCs involve divergent pathways including (but not limited to) estrogenic, antiandrogenic, thyroid, peroxisome proliferator-activated receptor , retinoid, and actions through other nuclear receptors; steroidogenic enzymes; neurotransmitter receptors and systems; and many other pathways that are highly conserved in wildlife and humans, and which can be modeled in laboratory in vitro and in vivo models. Furthermore, EDCs represent a broad class of molecules such as organochlorinated pesticides and industrial chemicals, plastics and plasticizers, fuels, and many other chemicals that are present in the environment or are in widespread use. We make a number of recommendations to increase understanding of effects of EDCs, including enhancing increased basic and clinical research, invoking the precautionary principle, and advocating involvement of individual and scientific society stakeholders in communicating and implementing changes in public policy and awareness. (Endocrine Reviews 30: 293–342, 2009)

Global Signatures and Dynamical Origins of the Little Ice Age and Medieval Climate Anomaly

Abstract: Global temperatures are known to have varied over the past 1500 years, but the spatial patterns have remained poorly defined. We used a global climate proxy network to reconstruct surface temperature patterns over this interval. The Medieval period is found to display warmth that matches or exceeds that of the past decade in some regions, but which falls well below recent levels globally. This period is marked by a tendency for La Nina-like conditions in the tropical Pacific. The coldest temperatures of the Little Ice Age are observed over the interval 1400 to 1700 C.E., with greatest cooling over the extratropical Northern Hemisphere continents. The patterns of temperature change imply dynamical responses of climate to natural radiative forcing changes involving El Nino and the North Atlantic Oscillation-Arctic Oscillation.

Enthalpy and the mechanics of AdS black holes

Abstract: We present geometric derivations of the Smarr formula for static AdS black holes and an expanded first law that includes variations in the cosmological constant. These two results are further related by a scaling argument based on Euler's theorem. The key new ingredient in the constructions is a two-form potential for the static Killing field. Surface integrals of the Killing potential determine the coefficient of the variation of Λ in the first law. This coefficient is proportional to a finite, effective volume for the region outside the AdS black hole horizon, which can also be interpreted as minus the volume excluded from a spatial slice by the black hole horizon. This effective volume also contributes to the Smarr formula. Since Λ is naturally thought of as a pressure, the new term in the first law has the form of effective volume times change in pressure that arises in the variation of the enthalpy in classical thermodynamics. This and related arguments suggest that the mass of an AdS black hole should be interpreted as the enthalpy of the spacetime.

Energy consumption in mobile phones: a measurement study and implications for network applications

Abstract: In this paper, we present a measurement study of the energy consumption characteristics of three widespread mobile networking technologies: 3G, GSM, and WiFi. We find that 3G and GSM incur a high tail energy overhead because of lingering in high power states after completing a transfer. Based on these measurements, we develop a model for the energy consumed by network activity for each technology.Using this model, we develop TailEnder, a protocol that reduces energy consumption of common mobile applications. For applications that can tolerate a small delay such as e-mail, TailEnder schedules transfers so as to minimize the cumulative energy consumed meeting user-specified deadlines. We show that the TailEnder scheduling algorithm is within a factor 2x of the optimal and show that any online algorithm can at best be within a factor 1.62x of the optimal. For applications like web search that can benefit from prefetching, TailEnder aggressively prefetches several times more data and improves user-specified response times while consuming less energy. We evaluate the benefits of TailEnder for three different case study applications - email, news feeds, and web search - based on real user logs and show significant reduction in energy consumption in each case. Experiments conducted on the mobile phone show that TailEnder can download 60% more news feed updates and download search results for more than 50% of web queries, compared to using the default policy.

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

Abstract: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

Abstract: The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to improve the quality of preclinical studies of purported acute stroke therapies Although recognized as reasonable, they have not been closely followed nor rigorously validated Substantial advances have occurred regarding the appropriate quality and breadth of preclinical testing for candidate acute stroke therapies for better clinical translation The updated STAIR preclinical recommendations reinforce the previous suggestions that reproducibly defining dose response and time windows with both histological and functional outcomes in multiple animal species with appropriate physiological monitoring is appropriate The updated STAIR recommendations include: the fundamentals of good scientific inquiry should be followed by eliminating randomization and assessment bias, a priori defining inclusion/exclusion criteria, performing appropriate power and sample size calculations, and disclosing potential conflicts of interest After initial evaluations in young, healthy male animals, further studies should be performed in females, aged animals, and animals with comorbid conditions such as hypertension, diabetes, and hypercholesterolemia Another consideration is the use of clinically relevant biomarkers in animal studies Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success

Modelling West Antarctic ice sheet growth and collapse through the past five million years

Abstract: Changes in Earth's orbit are known to influence climate shifts from cold glacials to warm interglacials. How the vast West Antarctic ice sheet responds to these fluctuations is uncertain but, because its collapse could raise sea levels by about 5 metres, of great interest. Naish et al. have analysed the AND-1B ocean sediment core, extracted from beneath the Ross Ice Shelf as part of the ANDRILL drilling project, and find evidence that the ice sheet collapsed periodically during the early Pliocene (3-5 million years ago), when atmospheric CO2 levels were similar to, or slightly higher than today's. The pattern of collapse suggests an influence of approximately 40,000-year cycles in the tilt of Earth's rotational axis (obliquity). Also in this issue of Nature, in a numerical modelling study focused on the past 5 million years in Antarctica, David Pollard and Robert DeConto combine ice sheet (land-supported) and ice shelf (water-supported) modelling approaches to simulate the movement of the grounding line — the border between land and sea ice. Their results show that over the past 5 million years, the West Antarctic ice sheet transitioned between full, intermediate, and collapsed states in just a few thousand years. This means that the ice sheet is likely to disintegrate if ocean temperatures in the area rise by 5 C. If the West Antarctic Ice Sheet (WAIS) melted, sea levels would rise by about 5 m; such changes are thought to have occurred in the past but could not be simulated by models. Pollard and DeConto combine ice-sheet with ice-shelf modelling, and show that over the past 5 million years, the WAIS transitioned among full, intermediate, and collapsed states in only a few thousand years, suggesting possible disintegration of the WAIS if ocean temperatures in the area rise by 5 °C. The West Antarctic ice sheet (WAIS), with ice volume equivalent to ∼5 m of sea level1, has long been considered capable of past and future catastrophic collapse2,3,4. Today, the ice sheet is fringed by vulnerable floating ice shelves that buttress the fast flow of inland ice streams. Grounding lines are several hundred metres below sea level and the bed deepens upstream, raising the prospect of runaway retreat3,5. Projections of future WAIS behaviour have been hampered by limited understanding of past variations and their underlying forcing mechanisms6,7. Its variation since the Last Glacial Maximum is best known, with grounding lines advancing to the continental-shelf edges around ∼15 kyr ago before retreating to near-modern locations by ∼3 kyr ago8. Prior collapses during the warmth of the early Pliocene epoch9 and some Pleistocene interglacials have been suggested indirectly from records of sea level and deep-sea-core isotopes, and by the discovery of open-ocean diatoms in subglacial sediments10. Until now11, however, little direct evidence of such behaviour has been available. Here we use a combined ice sheet/ice shelf model12 capable of high-resolution nesting with a new treatment of grounding-line dynamics and ice-shelf buttressing5 to simulate Antarctic ice sheet variations over the past five million years. Modelled WAIS variations range from full glacial extents with grounding lines near the continental shelf break, intermediate states similar to modern, and brief but dramatic retreats, leaving only small, isolated ice caps on West Antarctic islands. Transitions between glacial, intermediate and collapsed states are relatively rapid, taking one to several thousand years. Our simulation is in good agreement with a new sediment record (ANDRILL AND-1B) recovered from the western Ross Sea11, indicating a long-term trend from more frequently collapsed to more glaciated states, dominant 40-kyr cyclicity in the Pliocene, and major retreats at marine isotope stage 31 (∼1.07 Myr ago) and other super-interglacials.

Optical explosives detection: from color changes to fluorescence turn-on

Abstract: The detection of chemical explosives is crucial for military and civilian safety. A confluence of chemistry and engineering continues to improve the sensitivity for several classes of explosives, and holds the promise of cheap and portable sensing. Optical and fluorescence-based sensors have been extensively researched for portable applications due to their sensitivity and portability. This tutorial review discusses chemical approaches to sensing explosives based on an optical readout, and summarizes recent advances in fluorescence strategies, including fluorescence turn-on. It is of interest to researchers working in the areas of materials chemistry or forensics.

Structural causes of the global financial crisis: a critical assessment of the ‘new financial architecture’

Abstract: We are in the midst of the worst financial crisis since the Great Depression. This crisis is the latest phase of the evolution of financial markets under the radical financial deregulation process that began in the late 1970s. This evolution has taken the form of cycles in which deregulation accompanied by rapid financial innovation stimulates powerful financial booms that end in crises. Governments respond to crises with bailouts that allow new expansions to begin. As a result, financial markets have become ever larger and financial crises have become more threatening to society, which forces governments to enact ever larger bailouts. This process culminated in the current global financial crisis, which is so deeply rooted that even unprecedented interventions by affected governments have, thus far, failed to contain it. In this paper we analyse the structural flaws in the financial system that helped bring on the current crisis and discuss prospects for financial reform.

Evaluation methods for topic models

Abstract: A natural evaluation metric for statistical topic models is the probability of held-out documents given a trained model. While exact computation of this probability is intractable, several estimators for this probability have been used in the topic modeling literature, including the harmonic mean method and empirical likelihood method. In this paper, we demonstrate experimentally that commonly-used methods are unlikely to accurately estimate the probability of held-out documents, and propose two alternative methods that are both accurate and efficient.

Power-Up SRAM State as an Identifying Fingerprint and Source of True Random Numbers

Abstract: Intermittently powered applications create a need for low-cost security and privacy in potentially hostile environments, supported by primitives including identification and random number generation. Our measurements show that power-up of SRAM produces a physical fingerprint. We propose a system of fingerprint extraction and random numbers in SRAM (FERNS) that harvests static identity and randomness from existing volatile CMOS memory without requiring any dedicated circuitry. The identity results from manufacture-time physically random device threshold voltage mismatch, and the random numbers result from runtime physically random noise. We use experimental data from high-performance SRAM chips and the embedded SRAM of the WISP UHF RFID tag to validate the principles behind FERNS. For the SRAM chip, we demonstrate that 8-byte fingerprints can uniquely identify circuits among a population of 5,120 instances and extrapolate that 24-byte fingerprints would uniquely identify all instances ever produced. Using a smaller population, we demonstrate similar identifying ability from the embedded SRAM. In addition to identification, we show that SRAM fingerprints capture noise, enabling true random number generation. We demonstrate that a 512-byte SRAM fingerprint contains sufficient entropy to generate 128-bit true random numbers and that the generated numbers pass the NIST tests for runs, approximate entropy, and block frequency.

Structural design principles for delivery of bioactive components in nutraceuticals and functional foods.

Abstract: There have been major advances in the design and fabrication of structured delivery systems for the encapsulation of nutraceutical and functional food components. A wide variety of delivery systems is now available, each with its own advantages and disadvantages for particular applications. This review begins by discussing some of the major nutraceutical and functional food components that need to be delivered and highlights the main limitations to their current utilization within the food industry. It then discusses the principles underpinning the rational design of structured delivery systems: the structural characteristics of the building blocks; the nature of the forces holding these building blocks together; and, the different ways of assembling these building blocks into structured delivery systems. Finally, we review the major types of structured delivery systems that are currently available to food scientists: lipid-based (simple, multiple, multilayer, and solid lipid particle emulsions); surfactant-based (simple micelles, mixed micelles, vesicles, and microemulsions) and biopolymer-based (soluble complexes, coacervates, hydrogel droplets, and particles). For each type of delivery system we describe its preparation, properties, advantages, and limitations.

Galaxies in a simulated ΛCDM Universe – I. Cold mode and hot cores

Abstract: We study the formation of galaxies in a large volume (50 h −1 Mpc, 2 × 288 3 particles) cosmological simulation, evolved using the entropy and energy-conserving smoothed particle hydrodynamics (SPH) code GADGET-2. Most of the baryonic mass in galaxies of all masses is originally acquired through filamentary ‘cold mode’ accretion of gas that was never shock heated to its halo virial temperature, confirming the key feature of our earlier results obtained with a different SPH code. Atmospheres of hot, virialized gas develop in haloes above 2–3 × 10 11 M � , a transition mass that is nearly constant from z = 3 to 0. Cold accretion persists in haloes above the transition mass, especially at z ≥ 2. It dominates the growth of galaxies in low-mass haloes at all times, and it is the main driver of the cosmic star formation history. Our results suggest that the cooling of shock-heated virialized gas, which has been the focus of many analytic models of galaxy growth spanning more than three decades, might be a relatively minor element of galaxy formation. At high redshifts, satellite galaxies have gas accretion rates similar to central galaxies of the same baryonic mass, but at z < 1t he accretion rates of low-mass satellites are well below those of comparable central galaxies. Relative to our earlier simulations, the GADGET-2 simulations predict much lower rates of ‘hot mode’ accretion from the virialized gas component. Hot accretion rates compete with cold accretion rates near the transition mass, but only at z ≤ 1. Hot accretion is inefficient in haloes

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.

Abstract: Identification of full-length transmitted HIV-1 genomes could be instrumental in HIV-1 pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those viruses actually responsible for productive clinical infection. We show in 12 acutely infected subjects (9 clade B and 3 clade C) that complete HIV-1 genomes of transmitted/founder viruses can be inferred by single genome amplification and sequencing of plasma virion RNA. This allowed for the molecular cloning and biological analysis of transmitted/founder viruses and a comprehensive genome-wide assessment of the genetic imprint left on the evolving virus quasispecies by a composite of host selection pressures. Transmitted viruses encoded intact canonical genes ( gag-pol-vif-vpr-tat-rev-vpu-env-nef ) and replicated efficiently in primary human CD4+ T lymphocytes but much less so in monocyte-derived macrophages. Transmitted viruses were CD4 and CCR5 tropic and demonstrated concealment of coreceptor binding surfaces of the envelope bridging sheet and variable loop 3. 2 mo after infection, transmitted/founder viruses in three subjects were nearly completely replaced by viruses differing at two to five highly selected genomic loci; by 12–20 mo, viruses exhibited concentrated mutations at 17–34 discrete locations. These findings reveal viral properties associated with mucosal HIV-1 transmission and a limited set of rapidly evolving adaptive mutations driven primarily, but not exclusively, by early cytotoxic T cell responses.

Macroscopic 10-terabit-per-square-inch arrays from block copolymers with lateral order.

Abstract: Generating laterally ordered, ultradense, macroscopic arrays of nanoscopic elements will revolutionize the microelectronic and storage industries. We used faceted surfaces of commercially available sapphire wafers to guide the self-assembly of block copolymer microdomains into oriented arrays with quasi-long-range crystalline order over arbitrarily large wafer surfaces. Ordered arrays of cylindrical microdomains 3 nanometers in diameter, with areal densities in excess of 10 terabits per square inch, were produced. The sawtoothed substrate topography provides directional guidance to the self-assembly of the block copolymer, which is tolerant of surface defects, such as dislocations. The lateral ordering and lattice orientation of the single-grain arrays of microdomains are maintained over the entire surface. The approach described is parallel, applicable to different substrates and block copolymers, and opens a versatile route toward ultrahigh-density systems.

Rethinking LDA: Why Priors Matter

Abstract: Implementations of topic models typically use symmetric Dirichlet priors with fixed concentration parameters, with the implicit assumption that such "smoothing parameters" have little practical effect. In this paper, we explore several classes of structured priors for topic models. We find that an asymmetric Dirichlet prior over the document-topic distributions has substantial advantages over a symmetric prior, while an asymmetric prior over the topic-word distributions provides no real benefit. Approximation of this prior structure through simple, efficient hyperparameter optimization steps is sufficient to achieve these performance gains. The prior structure we advocate substantially increases the robustness of topic models to variations in the number of topics and to the highly skewed word frequency distributions common in natural language. Since this prior structure can be implemented using efficient algorithms that add negligible cost beyond standard inference techniques, we recommend it as a new standard for topic modeling.

The remnants of galaxy formation from a panoramic survey of the region around M31

Abstract: In hierarchical cosmological models, galaxies grow in mass through the continual accretion of smaller ones. The tidal disruption of these systems is expected to result in loosely bound stars surrounding the galaxy, at distances that reach 10-100 times the radius of the central disk. The number, luminosity and morphology of the relics of this process provide significant clues to galaxy formation history, but obtaining a comprehensive survey of these components is difficult because of their intrinsic faintness and vast extent. Here we report a panoramic survey of the Andromeda galaxy (M31). We detect stars and coherent structures that are almost certainly remnants of dwarf galaxies destroyed by the tidal field of M31. An improved census of their surviving counterparts implies that three-quarters of M31's satellites brighter than M(v) = -6 await discovery. The brightest companion, Triangulum (M33), is surrounded by a stellar structure that provides persuasive evidence for a recent encounter with M31. This panorama of galaxy structure directly confirms the basic tenets of the hierarchical galaxy formation model and reveals the shared history of M31 and M33 in the unceasing build-up of galaxies.

Dust-corrected Star Formation Rates of Galaxies. I. Combinations of Hα and Infrared Tracers

Abstract: We combine Halpha emission-line and infrared (IR) continuum measurements of two samples of nearby galaxies to derive dust attenuation-corrected star formation rates (SFRs). We use a simple energy balance based method that has been applied previously to H II regions in the Spitzer Infrared Nearby Galaxies Survey, and extend the methodology to integrated measurements of galaxies. We find that our composite Halpha + IR based SFRs are in excellent agreement with attenuation-corrected SFRs derived from integrated spectrophotometry, over the full range of SFRs (0.01-80 M {sub sun} yr{sup -1}) and attenuations (0-2.5 mag) studied. We find that the combination of Halpha and total IR luminosities provides the most robust SFR measurements, but combinations of Halpha measurements with monochromatic luminosities at 24 {mu}m and 8 {mu}m perform nearly as well. The calibrations differ significantly from those obtained for H II regions, with the difference attributable to a more evolved population of stars heating the dust. Our results are consistent with a significant component of diffuse dust (the 'IR cirrus' component) that is heated by a non-star-forming population. The same methodology can be applied to [O II]lambda3727 emission-line measurements, and the radio continuum fluxes of galaxies can be applied in place ofmore » IR fluxes when the latter are not available. We assess the precision and systematic reliability of all of these composite methods.« less

Block copolymer nanolithography: translation of molecular level control to nanoscale patterns

Abstract: The self-asembly of block copolymers is a promising platform for the "bottom-up" fabrication of nanostructured materials and devices. This review covers some of the advances made in this field from the laboratory setting to applications where block copolymers are in use.

Recent Warming Reverses Long-Term Arctic Cooling

Abstract: The temperature history of the first millennium C.E. is sparsely documented, especially in the Arctic. We present a synthesis of decadally resolved proxy temperature records from poleward of 60°N covering the past 2000 years, which indicates that a pervasive cooling in progress 2000 years ago continued through the Middle Ages and into the Little Ice Age. A 2000-year transient climate simulation with the Community Climate System Model shows the same temperature sensitivity to changes in insolation as does our proxy reconstruction, supporting the inference that this long-term trend was caused by the steady orbitally driven reduction in summer insolation. The cooling trend was reversed during the 20th century, with four of the five warmest decades of our 2000-year-long reconstruction occurring between 1950 and 2000.

Re-examining larson's scaling relationships in galactic molecular clouds

Abstract: The properties of Galactic molecular clouds tabulated by Solomon et al. (SRBY) are re-examined using the Boston University-FCRAO Galactic Ring Survey of 13CO J = 1-0 emission. These new data provide a lower opacity tracer of molecular clouds and improved angular and spectral resolution compared with previous surveys of molecular line emission along the Galactic Plane. We calculate giant molecular cloud (GMC) masses within the SRBY cloud boundaries assuming local thermodynamic equilibrium (LTE) conditions throughout the cloud and a constant H2 to 13CO abundance, while accounting for the variation of the 12C/13C with galactocentric radius. The LTE-derived masses are typically five times smaller than the SRBY virial masses. The corresponding median mass surface density of molecular hydrogen for this sample is 42 M ☉ pc–2, which is significantly lower than the value derived by SRBY (median 206 M ☉ pc–2) that has been widely adopted by most models of cloud evolution and star formation. This discrepancy arises from both the extrapolation by SRBY of velocity dispersion, size, and CO luminosity to the 1 K antenna temperature isophote that likely overestimates the GMC masses and our assumption of constant 13CO abundance over the projected area of each cloud. Owing to the uncertainty of molecular abundances in the envelopes of clouds, the mass surface density of GMCs could be larger than the values derived from our 13CO measurements. From velocity dispersions derived from the 13CO data, we find that the coefficient of the cloud structure functions, v ° = σ v /R 1/2, is not constant, as required to satisfy Larson's scaling relationships, but rather systematically varies with the surface density of the cloud as ~Σ0.5 as expected for clouds in self-gravitational equilibrium.

Aromatic Production from Catalytic Fast Pyrolysis of Biomass-Derived Feedstocks

Abstract: The conversion of biomass compounds to aromatics by thermal decomposition in the presence of catalysts was investigated using a pyroprobe analytical pyrolyzer The first step in this process is the thermal decomposition of the biomass to smaller oxygenates that then enter the catalysts pores where they are converted to CO, CO2, water, coke and volatile aromatics The desired reaction is the conversion of biomass into aromatics, CO2 and water with the undesired products being coke and water Both the reaction conditions and catalyst properties are critical in maximizing the desired product selectivity High heating rates and high catalyst to feed ratio favor aromatic production over coke formation Aromatics with carbon yields in excess of 30 molar carbon% were obtained from glucose, xylitol, cellobiose, and cellulose with ZSM-5 (Si/Al = 60) at the optimal reactor conditions The aromatic yield for all the products was similar suggesting that all of these biomass-derived oxygenates go through a common intermediate At lower catalyst to feed ratios volatile oxygenates are formed including furan type compounds, acetic acid and hydroxyacetaldehyde The product selectivity is dependent on both the size of the catalyst pores and the nature of the active sites Five catalysts were tested including ZSM-5, silicalite, beta, Y-zeolite and silica–alumina ZSM-5 had the highest aromatic yields (30% carbon yield) and the least amount of coke

Global cooling during the eocene-oligocene climate transition.

Abstract: About 34 million years ago, Earth's climate shifted from a relatively ice-free world to one with glacial conditions on Antarctica characterized by substantial ice sheets. How Earth's temperature changed during this climate transition remains poorly understood, and evidence for Northern Hemisphere polar ice is controversial. Here, we report proxy records of sea surface temperatures from multiple ocean localities and show that the high-latitude temperature decrease was substantial and heterogeneous. High-latitude (45 degrees to 70 degrees in both hemispheres) temperatures before the climate transition were ∼20°C and cooled an average of ∼5°C. Our results, combined with ocean and ice-sheet model simulations and benthic oxygen isotope records, indicate that Northern Hemisphere glaciation was not required to accommodate the magnitude of continental ice growth during this time.

Antifungal Activity of Silver Ions and Nanoparticles on Phytopathogenic Fungi.

Abstract: Silver in ionic or nanoparticle forms has a high antimicrobial activity and is therefore widely used for various sterilization purposes including materials of medical devices and water san...

Obliquity-paced Pliocene West Antarctic ice sheet oscillations

Abstract: Thirty years after oxygen isotope records from microfossils deposited in ocean sediments confirmed the hypothesis that variations in the Earth's orbital geometry control the ice ages, fundamental questions remain over the response of the Antarctic ice sheets to orbital cycles. Furthermore, an understanding of the behaviour of the marine-based West Antarctic ice sheet (WAIS) during the 'warmer-than-present' early-Pliocene epoch ( approximately 5-3 Myr ago) is needed to better constrain the possible range of ice-sheet behaviour in the context of future global warming. Here we present a marine glacial record from the upper 600 m of the AND-1B sediment core recovered from beneath the northwest part of the Ross ice shelf by the ANDRILL programme and demonstrate well-dated, approximately 40-kyr cyclic variations in ice-sheet extent linked to cycles in insolation influenced by changes in the Earth's axial tilt (obliquity) during the Pliocene. Our data provide direct evidence for orbitally induced oscillations in the WAIS, which periodically collapsed, resulting in a switch from grounded ice, or ice shelves, to open waters in the Ross embayment when planetary temperatures were up to approximately 3 degrees C warmer than today and atmospheric CO(2) concentration was as high as approximately 400 p.p.m.v. (refs 5, 6). The evidence is consistent with a new ice-sheet/ice-shelf model that simulates fluctuations in Antarctic ice volume of up to +7 m in equivalent sea level associated with the loss of the WAIS and up to +3 m in equivalent sea level from the East Antarctic ice sheet, in response to ocean-induced melting paced by obliquity. During interglacial times, diatomaceous sediments indicate high surface-water productivity, minimal summer sea ice and air temperatures above freezing, suggesting an additional influence of surface melt under conditions of elevated CO(2).