University of Massachusetts Amherst

About: University of Massachusetts Amherst is a education organization based out in Amherst Center, Massachusetts, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 37274 authors who have published 83965 publications receiving 3834996 citations. The organization is also known as: UMass Amherst & Massachusetts State College.

An analytical model for multi-tier internet services and its applications

Abstract: Since many Internet applications employ a multi-tier architecture, in this paper, we focus on the problem of analytically modeling the behavior of such applications. We present a model based on a network of queues, where the queues represent different tiers of the application. Our model is sufficiently general to capture (i) the behavior of tiers with significantly different performance characteristics and (ii) application idiosyncrasies such as session-based workloads, concurrency limits, and caching at intermediate tiers. We validate our model using real multi-tier applications running on a Linux server cluster. Our experiments indicate that our model faithfully captures the performance of these applications for a number of workloads and configurations. For a variety of scenarios, including those with caching at one of the application tiers, the average response times predicted by our model were within the 95% confidence intervals of the observed average response times. Our experiments also demonstrate the utility of the model for dynamic capacity provisioning, performance prediction, bottleneck identification, and session policing. In one scenario, where the request arrival rate increased from less than 1500 to nearly 4200 requests/min, a dynamic provisioning technique employing our model was able to maintain response time targets by increasing the capacity of two of the application tiers by factors of 2 and 3.5, respectively.

Cross-Group Friendships and Intergroup Attitudes A Meta-Analytic Review

Abstract: This work identifies how cross-group friendships are conceptualized and measured in intergroup research, investigates which operationalizations yield the strongest effects on intergroup attitudes, explores potential moderators, and discusses the theoretical importance of the findings. Prior meta-analyses have provided initial evidence that cross-group friendships are especially powerful forms of intergroup contact. Although studies of cross-group friendship have grown considerably in recent years, varied assessments leave us without a clear understanding of how different operationalizations affect relationships between friendship and attitudes. With a greatly expanded database of relevant studies, the authors compared friendship-attitude associations across a wide range of specific conceptualizations. Time spent and self-disclosure with outgroup friends yielded significantly greater associations with attitudes than other friendship measures, suggesting that attitudes are most likely to improve when cross-group friendships involve behavioral engagement. Processes underlying cross-group friendships are discussed, as are implications for future research and application.

Exercise-Induced Muscle Damage and Adaptation

Abstract: Novel, unaccustomed exercise has been shown to result in temporary, repairable skeletal muscle damage. After exhaustive endurance exercise, muscle damage can be produced by metabolic disturbances associated with ischaemia. Extensive disruption of muscle fibres also occurs after relatively short term eccentric exercise where high mechanical forces are generated. Biopsies taken after repetitive eccentric muscle actions have revealed broadening, streaming and, at times, total disruption of Z-discs. Muscles that develop active tension eccentrically also become sore, lose inherent force-producing capability, and show a marked release of muscle proteins into the circulation. Because creatine kinase (CK) is found almost exclusively in muscle tissue, it is the most common plasma marker of muscle damage. Despite the universal use of CK as a marker, several factors with regard to efflux and clearance remain unexplained. Also the large intersubject variability in response to exercise complicates its interpretation. Damage progresses in the postexercise period before tissues are repaired. However, the mechanism to explain exercise-induced muscle damage and repair is not well defined. Among the factors that may influence the damage and repair processes are calcium, lysosomes, connective tissue, free radicals, energy sources, and cytoskeletal and myofibrillar proteins. Physical conditioning results in an adaptation such that all indicators of damage are reduced following repeated bouts of exercise. Recently, investigators have suggested that the prophylactic effect of training may be due to performance of a single initial exercise bout. Following a second bout of exercise performed 1 to 6 weeks after the first bout, there is a reduction in morphological alterations and performance decrements and a profoundly reduced elevation in plasma CK levels. Several hypotheses have been presented to explain the repeated bout or rapid training effect. Stress-susceptible fibres may be eliminated or susceptible areas within a fibre may undergo necrosis and then regenerate. These regenerated fibres, along with adaptations in the connective tissue, may provide greater resistance to further insult.

In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

Abstract: A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter cotranslationally in the ER lumen, which contains resident molecular chaperones and folding factors that assist their maturation. Native proteins are released from the ER lumen and are transported through the secretory pathway to their final intra- or extracellular destination. Folding-defective polypeptides are exported across the ER membrane into the cytosol and destroyed. Cellular and organismal homeostasis relies on a balanced activity of the ER folding, quality control, and degradation machineries as shown by the dozens of human diseases related to defective maturation or disposal of individual polypeptides generated in the ER.