University of Massachusetts Amherst

About: University of Massachusetts Amherst is a education organization based out in Amherst Center, Massachusetts, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 37274 authors who have published 83965 publications receiving 3834996 citations. The organization is also known as: UMass Amherst & Massachusetts State College.

The Algebra of Events.

Abstract: A number of writers have commented on the close parallels between the mass-count distinction in nominal systems and the aspectual classification of verbal expressions (Allen, 1966; Mourelatos, 1978; L. Carlson, 1981; Hoepelman and Rohrer, 1980) that has been the subject of much attention in recent years in linguistics and philosophy. To take just one class of examples for now, there is a parallel between the two sets of distinctions in their cooccurrence patterns with expressions denoting numbers or amounts, as in Examples (1a)–(4b):

Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria

Abstract: We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface provided gold nanoparticles that were effective against both Gram-negative and Gram-positive uropathogens, including multi-drug-resistant pathogens. These AuNPs exhibited low toxicity to mammalian cells, and bacterial resistance was not observed after 20 generations. A strong structure–activity relationship was observed as a function of AuNP functionality, providing guidance to activity prediction and rational design of effective antimicrobial nanoparticles.

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.

Abstract: Truncated Notch receptors have transforming activity in vitro and in vivo. However, the role of wild-type Notch signaling in neoplastic transformation remains unclear. Ras signaling is deregulated in a large fraction of human malignancies and is a major target for the development of novel cancer treatments. We show that oncogenic Ras activates Notch signaling and that wild-type Notch-1 is necessary to maintain the neoplastic phenotype in Ras-transformed human cells in vitro and in vivo. Oncogenic Ras increases levels and activity of the intracellular form of wild-type Notch-1, and upregulates Notch ligand Delta-1 and also presenilin-1, a protein involved in Notch processing, through a p38-mediated pathway. These observations place Notch signaling among key downstream effectors of oncogenic Ras and suggest that it might be a novel therapeutic target.

The size evolution of galaxies since z~3: combining SDSS, GEMS, and FIRES

Abstract: We present the evolution of the luminosity-size and stellar mass-size relations of luminous ( L-V greater than or similar to 3.4 x 10(10) h(70)(-2) L-circle dot) and massive ( M-* greater than or similar to 3 x 10(10) h(70)(-2) M-circle dot) galaxies in the last similar to 11 Gyr. We use very deep near-infrared images of the Hubble Deep Field-South and the MS 1054-03 field in the J(s), H, and K-s bands from FIRES to retrieve the sizes in the optical rest frame for galaxies with z > 1. We combine our results with those from GEMS at 0.2 < z < 1 and SDSS at z similar to 0.1 to achieve a comprehensive picture of the optical rest-frame size evolution from z = 0 to 3. Galaxies are differentiated according to their light concentration using the Sersic index n. For less concentrated objects, the galaxies at a given luminosity were typically similar to 3 +/- 0.5 ( +/- 2 sigma) times smaller at z similar to 2: 5 than those we see today. The stellar mass-size relation has evolved less: the mean size at a given stellar mass was similar to 2 +/- 0.5 times smaller at z similar to 2.5, evolving proportionally to ( 1 + z) - 0.40 +/- 0.06. Simple scaling relations between dark matter halos and baryons in a hierarchical cosmogony predict a stronger ( although consistent within the error bars) than observed evolution of the stellar mass-size relation. The observed luminosity-size evolution out to z similar to 2.5 matches well recent infall model predictions for Milky Way-type objects. For low-n galaxies, the evolution of the stellar mass-size relation would follow naturally if the individual galaxies grow inside out. For highly concentrated objects, the situation is as follows: at a given luminosity, these galaxies were similar to 2.7 +/- 1.1 times smaller at z similar to 2.5 ( or, put differently, were typically similar to 2.2 +/- 0.7 mag brighter at a given size than they are today), and at a given stellar mass the size has evolved proportionally to ( 1 + z)(-0.45 +/- 0.10).

The Top 10 oomycete pathogens in molecular plant pathology

Abstract: Oomycetes form a deep lineage of eukaryotic organisms that includes a large number of plant pathogens which threaten natural and managed ecosystems. We undertook a survey to query the community for their ranking of plant-pathogenic oomycete species based on scientific and economic importance. In total, we received 263 votes from 62 scientists in 15 countries for a total of 33 species. The Top 10 species and their ranking are: (1) Phytophthora infestans; (2, tied) Hyaloperonospora arabidopsidis; (2, tied) Phytophthora ramorum; (4) Phytophthora sojae; (5) Phytophthora capsici; (6) Plasmopara viticola; (7) Phytophthora cinnamomi; (8, tied) Phytophthora parasitica; (8, tied) Pythium ultimum; and (10) Albugo candida. This article provides an introduction to these 10 taxa and a snapshot of current research. We hope that the list will serve as a benchmark for future trends in oomycete research.