University of Massachusetts Amherst

About: University of Massachusetts Amherst is a education organization based out in Amherst Center, Massachusetts, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 37274 authors who have published 83965 publications receiving 3834996 citations. The organization is also known as: UMass Amherst & Massachusetts State College.

Resistive switching materials for information processing

Abstract: The rapid increase in information in the big-data era calls for changes to information-processing paradigms, which, in turn, demand new circuit-building blocks to overcome the decreasing cost-effectiveness of transistor scaling and the intrinsic inefficiency of using transistors in non-von Neumann computing architectures. Accordingly, resistive switching materials (RSMs) based on different physical principles have emerged for memories that could enable energy-efficient and area-efficient in-memory computing. In this Review, we survey the four physical mechanisms that lead to such resistive switching: redox reactions, phase transitions, spin-polarized tunnelling and ferroelectric polarization. We discuss how these mechanisms equip RSMs with desirable properties for representation capability, switching speed and energy, reliability and device density. These properties are the key enablers of processing-in-memory platforms, with applications ranging from neuromorphic computing and general-purpose memcomputing to cybersecurity. Finally, we examine the device requirements for such systems based on RSMs and provide suggestions to address challenges in materials engineering, device optimization, system integration and algorithm design. Resistive switching materials enable novel, in-memory information processing, which may resolve the von Neumann bottleneck. This Review focuses on how the switching mechanisms and the resultant electrical properties lead to various computing applications.

Boosting the accuracy of differentially private histograms through consistency

Abstract: We show that it is possible to significantly improve the accuracy of a general class of histogram queries while satisfying differential privacy. Our approach carefully chooses a set of queries to evaluate, and then exploits consistency constraints that should hold over the noisy output. In a post-processing phase, we compute the consistent input most likely to have produced the noisy output. The final output is differentially-private and consistent, but in addition, it is often much more accurate. We show, both theoretically and experimentally, that these techniques can be used for estimating the degree sequence of a graph very precisely, and for computing a histogram that can support arbitrary range queries accurately.

Interleukin-6 Overexpression Induces Pulmonary Hypertension

Abstract: Inflammatory cytokine interleukin (IL)-6 is elevated in the serum and lungs of patients with pulmonary artery hypertension (PAH). Several animal models of PAH cite the potential role of inflammatory mediators. We investigated role of IL-6 in the pathogenesis of pulmonary vascular disease. Indices of pulmonary vascular remodeling were measured in lung-specific IL-6-overexpressing transgenic mice (Tg(+)) and compared to wild-type (Tg(-)) controls in both normoxic and chronic hypoxic conditions. The Tg(+) mice exhibited elevated right ventricular systolic pressures and right ventricular hypertrophy with corresponding pulmonary vasculopathic changes, all of which were exacerbated by chronic hypoxia. IL-6 overexpression increased muscularization of the proximal arterial tree, and hypoxia enhanced this effect. It also reproduced the muscularization and proliferative arteriopathy seen in the distal arteriolar vessels of PAH patients. The latter was characterized by the formation of occlusive neointimal angioproliferative lesions that worsened with hypoxia and were composed of endothelial cells and T-lymphocytes. IL-6-induced arteriopathic changes were accompanied by activation of proangiogenic factor, vascular endothelial growth factor, the proproliferative kinase extracellular signal-regulated kinase, proproliferative transcription factors c-MYC and MAX, and the antiapoptotic proteins survivin and Bcl-2 and downregulation of the growth inhibitor transforming growth factor-beta and proapoptotic kinases JNK and p38. These findings suggest that IL-6 promotes the development and progression of pulmonary vascular remodeling and PAH through proproliferative antiapoptotic mechanisms.

Anatomical Data for Analyzing Human Motion

Abstract: Anatomical data necessary for the analysis of human motion are presented on the total living body segmented into sixteen parts. Cadaver data from Dempster (1955) are applied to water displacement data obtained on 135 living subjects (35 men and 100 women) to obtain the weight, center of gravity, and radius of gyration for the segmented extremities. Thirty-three of these subjects (15 men and 18 women) were used to obtain the weight of the segments of the trunk, using the water displacement method, and sixteen of these subjects (7 men and 9 women) were used to locate the center of gravity of each trunk segment. A lead model was constructed using the trunk data to obtain the radii of gyration in both the sagittal and frontal planes. A single male cadaver was dissected to compare the trunk measurements with the lead model results.