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Institution

University of Massachusetts Boston

EducationBoston, Massachusetts, United States
About: University of Massachusetts Boston is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Health care. The organization has 6541 authors who have published 12918 publications receiving 411731 citations. The organization is also known as: UMass Boston.


Papers
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Journal ArticleDOI
TL;DR: RNA titration samples may be regarded as a valuable tool, not only for assessing microarray platform performance and different analysis methods, but also for determining some underlying biological features of the samples.
Abstract: We have assessed the utility of RNA titration samples for evaluating microarray platform performance and the impact of different normalization methods on the results obtained. As part of the MicroArray Quality Control project, we investigated the performance of five commercial microarray platforms using two independent RNA samples and two titration mixtures of these samples. Focusing on 12,091 genes common across all platforms, we determined the ability of each platform to detect the correct titration response across the samples. Global deviations from the response predicted by the titration ratios were observed. These differences could be explained by variations in relative amounts of messenger RNA as a fraction of total RNA between the two independent samples. Overall, both the qualitative and quantitative correspondence across platforms was high. In summary, titration samples may be regarded as a valuable tool, not only for assessing microarray platform performance and different analysis methods, but also for determining some underlying biological features of the samples.

178 citations

Journal ArticleDOI
TL;DR: The NNNS may be useful to identify infant behavioral needs to be targeted in well-infant pediatric care, as well as for referrals to community-based early intervention services.
Abstract: OBJECTIVE: This study examined the NICU Network Neurobehavioral Scale (NNNS) as a predictor of negative medical and behavioral findings at 1 month to 4.5 years of age. METHODS: The sample included 1248 mother–infant dyads (42% born at RESULTS: Five discrete behavioral profiles were reliably identified; the most extreme negative profile was found in 5.8% of the infants. The profiles showed statistically significant associations with prenatal drug exposure; GA and birth weight; head ultrasound; neurologic and brain disease findings; and abnormal scores on measures of behavior problems, school readiness, and IQ through 4.5 years of age. CONCLUSIONS: The NNNS may be useful to identify infant behavioral needs to be targeted in well-infant pediatric care, as well as for referrals to community-based early intervention services.

177 citations

Journal ArticleDOI
TL;DR: Outcomes for men with a clinical diagnosis of benign prostatic hyperplasia depend onInitial symptom severity, however, the course of symptoms also varies among patients even with the same initial symptom severity.

177 citations

Journal ArticleDOI
TL;DR: It is demonstrated that the roots of regulatory resilience originate in infants' relationship with their caregiver and that maternal sensitivity can help or hinder the growth of resilience.

177 citations

Journal ArticleDOI
TL;DR: The hypothesis that autism involves deficits in understanding other minds is referred to as the "theory of mind" hypothesis of autism, and there is considerable evidence to support this hypothesis.
Abstract: Over the past 25 years there has been considerable interest in understanding the nature of the language and communicative impairments that are among the primary characteristics of autism. Initial work in the 1970s focused on the computational aspects of language (phonology, syntax, and morphology), but these studies concluded that there were no specific impairments in this aspect of language in children with autism (Tager-Flusberg, 1981). During the 1980s the hypothesis that autism could be explained in terms of deficits in semantic and conceptual development was also refuted (Tager-Flusberg, 1988). At the same time, it became increasingly clear that pragrnatics, or the appropriate use of language in social and communicative contexts, was one area of language that was seriously impaired in autism (Tager-Flusberg, 1981). Recently, there has been a move toward providing a unifying theoretical account to explain the specific pattern of language and communicative functioning in autism. Research on the social and cognitive impairments in autism have led to the hypothesis that autism involves deficits in understanding other minds, referred to as the \"theory of mind\" hypothesis of autism (Baron-Cohen, Tager-Flusberg, & Cohen, 1993). According to this hypothesis autistic individuals have profound difficulty interpreting a person's actions within a mentalistic framework, and there is considerable evidence to support this hypothesis. This impairment involves problems in social-affective relatedness to other people (Hobson, 1993), beginning during the first year of life, followed by a more advanced cognitive deficit in rep-

177 citations


Authors

Showing all 6667 results

NameH-indexPapersCitations
Derek R. Lovley16858295315
Wei Li1581855124748
Susan E. Hankinson15178988297
Roger J. Davis147498103478
Thomas P. Russell141101280055
George Alverson1401653105074
Robert H. Brown136117479247
C. Dallapiccola1361717101947
Paul T. Costa13340688454
Robert R. McCrae13231390960
David Julian McClements131113771123
Mauro Giavalisco12841269967
Benjamin Brau12897172704
Douglas T. Golenbock12331761267
Zhifeng Ren12269571212
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202367
2022131
2021833
2020851
2019823
2018776