University of Medicine and Dentistry of New Jersey

About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Pregnancy. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.

Nucleolin is a histone chaperone with FACT-like activity and assists remodeling of nucleosomes

Abstract: Remodeling machines play an essential role in the control of gene expression, but how their activity is regulated is not known. Here we report that the nuclear protein nucleolin possesses a histone chaperone activity and that this factor greatly enhances the activity of the chromatin remodeling machineries SWI/SNF and ACF. Interestingly, nucleolin is able to induce the remodeling by SWI/SNF of macroH2A, but not of H2ABbd nucleosomes, which are otherwise resistant to remodeling. This new histone chaperone promotes the destabilization of the histone octamer, helping the dissociation of a H2A–H2B dimer, and stimulates the SWI/SNF-mediated transfer of H2A–H2B dimers. Furthermore, nucleolin facilitates transcription through the nucleosome, which is reminiscent of the activity of the FACT complex. This work defines new functions for histone chaperones in chromatin remodeling and regulation of transcription and explains how nucleolin could act on transcription.

Delayed brain injury after head trauma: significance of coagulopathy.

Abstract: We reviewed the records of 253 patients with head injury who required serial computed tomographic (CT) scans; 123 (486%) developed delayed brain injury as evidenced by new or progressive lesions after a CT scan An abnormality in the prothrombin time, partial thromboplastin time, or platelet count at admission was present in 55% of the patients who showed evidence of delayed injury, and only 9% of those whose subsequent CT scans were unchanged or improved from the time of admission (P less than 0001) Among patients developing delayed injury, mean prothrombin time at admission was significantly longer (146 vs 126 s, P less than 0001) and partial thromboplastin time was significantly longer (369 vs 292 s, P less than 0001) than patients who did not have delayed injury If coagulation studies at admission were normal, a patient with head injury had a 31% risk of developing delayed insults This risk rose to almost 85% if at least one clotting test at admission was abnormal (P less than 0001) We conclude that clotting studies at admission are of value in predicting the occurrence of delayed injury If coagulopathy is discovered in the patient with head injury early follow-up CT scanning is advocated to discover progressive and new intracranial lesions that are likely to occur

Resting Network Plasticity Following Brain Injury

Abstract: The purpose of this study was to examine neural network properties at separate time-points during recovery from traumatic brain injury (TBI) using graph theory. Whole-brain analyses of the topological properties of the fMRI signal were conducted in 6 participants at 3 months and 6 months following severe TBI. Results revealed alterations of network properties including a change in the degree distribution, reduced overall strength in connectivity, and increased “small-worldness” from 3 months to 6 months post injury. The findings here indicate that, during recovery from injury, the strength but not the number of network connections diminishes, so that over the course of recovery, the network begins to approximate what is observed in healthy adults. These are the first data examining functional connectivity in a disrupted neural system during recovery.