Institution
University of Medicine and Dentistry of New Jersey
Education•
About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Pregnancy. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.
Topics: Population, Pregnancy, Poison control, Gene, Receptor
Papers published on a yearly basis
Papers
More filters
TL;DR: In this paper, a review of the currently available literature shows that in patients with uncomplicated hypertension, there is a paucity of data or absence of evidence to support use of beta-blockers as monotherapy or as first-line agents.
216 citations
TL;DR: Treatment of mammalian cells or yeast cells expressing human DNA TOP1 with camptothecin (CPT) induces covalent modification of the TOP1 by SUMO-1/Smt3p, a ubiquitin-like protein.
Abstract: Ubiquitin/26S proteasome-dependent degradation of topoisomerase I (TOP1) has been suggested to be a unique repair response to TOP1-mediated DNA damage. In the current study, we show that treatment of mammalian cells or yeast cells expressing human DNA TOP1 with camptothecin (CPT) induces covalent modification of the TOP1 by SUMO-1/Smt3p, a ubiquitin-like protein. This conclusion is based on the following observations: (i) Mammalian DNA TOP1 conjugates induced by CPT were cross-reactive with SUMO-1/Smt3p-specific antibodies both in yeast expressing human DNA TOP1 as well as mammalian cells. (ii) The formation of TOP1 conjugates was shown to be dependent on UBC9, the E2 enzyme for SUMO-1/Smt3p. (iii) TOP1 physically interacts with UBC9. (iv) Ubc9 mutant yeast cells expressing human DNA TOP1 was hypersensitive to CPT, suggesting that UBC9/SUMO-1 may be involved in the repair of TOP1-mediated DNA damage.
216 citations
TL;DR: The crystal structure of bovine NPC2 bound to cholesterol-3-O-sulfate, an analog that binds with greater apparent affinity than cholesterol, provides evidence of a malleable binding site, consistent with the previously documented broad range of sterol ligand specificity.
216 citations
TL;DR: The goal of this article is to provide a practical guide to the use of echo techniques in mice to evaluate cardiac systolic and diastolic function.
Abstract: Murine models have been utilized with increasing frequency mainly due to availability of genetically engineered models With advancement in high spatial and temporal resolution, echocardiography is used extensively for the evaluation of cardiovascular function in murine models of cardiovascular disease This review summarizes the general applications and methods involved in echocardiography used to study mouse models for cardiovascular research, based on 20 years of experience in our laboratory The goal of this article is to provide a practical guide to the use of echo techniques in mice to evaluate cardiac systolic and diastolic function
216 citations
TL;DR: Changes are common when interventions are implemented into practice settings and the translation of evidence into practice will be improved when research design and reporting standards are modified to help quality-improvement teams understand both these adaptations and the effort required to implement interventions in practice.
216 citations
Authors
Showing all 14639 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Virginia M.-Y. Lee | 194 | 993 | 148820 |
| Danny Reinberg | 145 | 342 | 68201 |
| Michael F. Holick | 145 | 767 | 107937 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Arnold J. Levine | 139 | 485 | 116005 |
| Aaron T. Beck | 139 | 536 | 170816 |
| Charles J. Yeo | 136 | 672 | 76424 |
| Jerry W. Shay | 133 | 639 | 74774 |
| Chung S. Yang | 128 | 560 | 56265 |
| Paul G. Falkowski | 127 | 378 | 64898 |
| Csaba Szabó | 123 | 958 | 61791 |
| William C. Roberts | 122 | 1117 | 55285 |
| Bryan R. Cullen | 121 | 371 | 50901 |
| John R. Perfect | 119 | 573 | 52325 |