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University of Medicine and Dentistry of New Jersey
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About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Poison control. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.
Topics: Population, Poison control, Pregnancy, Health care, Gene
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TL;DR: Weight gained at an excessive rate by women with a pregravid BMI in the normal range does not greatly enhance fetal growth and gestation duration, contributing instead to postpartum maternal overweight.
214 citations
TL;DR: A complex Ca2+ mechanism is established that targets the balance of CaMKII/CaN-PP1 activation to control distinct growth cone responses and mediates netrin-1 guidance.
213 citations
TL;DR: Control of antibiotic-resistant pathogens will provide a major challenge for both the medical community and society in general, and the implication of a failure to meet this challenge is the eventual arrival of the "post antibiotic era."
213 citations
TL;DR: It is reported that TGF-β does not directly promote Th17 cell differentiation but instead acts indirectly by blocking expression of the transcription factors signal transducer and activator of transcription (STAT) 4 and GATA-3, thus preventing Th1 and Th2 cell differentiation.
Abstract: Interleukin (IL)-17–producing T helper (Th17) cells play a critical role in the pathophysiology of several autoimmune disorders. The differentiation of Th17 cells requires the simultaneous presence of an unusual combination of cytokines: IL-6, a proinflammatory cytokine, and transforming growth factor (TGF) β, an antiinflammatory cytokine. However, the molecular mechanisms by which TGF-β exerts its effects on Th17 cell differentiation remain elusive. We report that TGF-β does not directly promote Th17 cell differentiation but instead acts indirectly by blocking expression of the transcription factors signal transducer and activator of transcription (STAT) 4 and GATA-3, thus preventing Th1 and Th2 cell differentiation. In contrast, TGF-β had no effect on the expression of retinoic acid receptor–related orphan nuclear receptor γt, a Th17-specific transcription factor. Interestingly, in Stat-6−/−T-bet−/− mice, which are unable to generate Th1 and Th2 cells, IL-6 alone was sufficient to induce robust differentiation of Th17 cells, whereas TGF-β had no effect, suggesting that TGF-β is dispensable for Th17 cell development. Consequently, BALB/c Stat-6−/−T-bet−/− mice, but not wild-type BALB/c mice, were highly susceptible to the development of experimental autoimmune encephalomyelitis, which could be blocked by anti–IL-17 antibodies but not by anti–TGF-β antibodies. Collectively, these data provide evidence that TGF-β is not directly required for the molecular orchestration of Th17 cell differentiation.
213 citations
TL;DR: Patients undergoing video-assisted thoracic operations seem to have reduced postoperative pain, shorter hospitalization, and quicker recovery times, and this new modality appears to have beneficial value for patients; however, only further experience will determine its true merits.
213 citations
Authors
Showing all 14639 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Virginia M.-Y. Lee | 194 | 993 | 148820 |
| Danny Reinberg | 145 | 342 | 68201 |
| Michael F. Holick | 145 | 767 | 107937 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Arnold J. Levine | 139 | 485 | 116005 |
| Aaron T. Beck | 139 | 536 | 170816 |
| Charles J. Yeo | 136 | 672 | 76424 |
| Jerry W. Shay | 133 | 639 | 74774 |
| Chung S. Yang | 128 | 560 | 56265 |
| Paul G. Falkowski | 127 | 378 | 64898 |
| Csaba Szabó | 123 | 958 | 61791 |
| William C. Roberts | 122 | 1117 | 55285 |
| Bryan R. Cullen | 121 | 371 | 50901 |
| John R. Perfect | 119 | 573 | 52325 |