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University of Medicine and Dentistry of New Jersey
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About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Poison control. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.
Topics: Population, Poison control, Pregnancy, Health care, Gene
Papers published on a yearly basis
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TL;DR: Despite an apparently sufficient weight gain and the accumulation of abundant stores during pregnancy, young still-growing women appeared not to mobilize fat reserves late in pregnancy to enhance fetal growth, apparently reserving them instead for their own continued development.
211 citations
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TL;DR: The data strongly support the notion that the type I genes have evolved from an ancestral multi-exon unit, and that once the gene was translated, a strong evolutionary pressure caused it to maintain this elaborate structure.
Abstract: The collagens represent an interesting example of a structurally related but genetically distinct family of proteins1. Type I, the most abundant of the vertebrate collagens, comprises two proα1(I) chains and one proα2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) repeats. The structure of the chicken proα2(I) gene shows an intriguing relationship between exon organization and the arrangement of (Gly, X, Y) repeats (see ref. 2 for review). This has led to the suggestion3 that the collagens evolved from a common ancestral unit of 54 base pairs (bp). Here we present the structure of the entire human proα1(I) gene and compare this with the chicken proα2(I). The exon arrangement of the two genes is remarkably similar, although the human proα1(I) is more compact because of the shorter length of its introns. The data strongly support the notion that the type I genes have evolved from an ancestral multi-exon unit, and that once the gene was translated, a strong evolutionary pressure caused it to maintain this elaborate structure.
211 citations
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TL;DR: The work elucidated the mechanism of a functional miRSNP 829C→T present in 3’ UTR of dihydrofolate reductase, an important drug target and highlighted the importance of these miRSNPs or miR-polymorphisms in gene regulation and the mechanism by which they can induce variability in the SNP expressing mutant cell by using drug resistance as an example.
Abstract: MicroRNAs are evolutionarily conserved small non-coding RNAs known to inhibit the translation of proteins by binding to the target transcript in the 3' untranslated region. Functional polymorphisms in 3' UTRs of several genes have been reported to be associated with diseases by affecting gene expression. The mechanism by which these polymorphisms affect gene expression and induce variability in a cell is not well understood. It has been suggested that these polymorphisms may interfere with regulatory elements that bind to untranslated region of a gene. Recently, a novel class of functional polymorphisms termed miRSNPs/polymorphisms was reported. defined as a polymorphism present at or near a microRNA binding sites of functional genes that can affect gene expression by interfering with a miRNA function. The work elucidated the mechanism of a functional miRSNP 829C-->T present in 3' UTR of dihydrofolate reductase, an important drug target. The SNP interferes with the miR24 microRNA function and leads to DHFR over expression and methotrexate resistance. In this article we highlight the importance of these miRSNPs or miR-polymorphisms in gene regulation and the mechanism by which these miRSNPs can induce variability in the SNP expressing mutant cell by using drug resistance as an example.
210 citations
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TL;DR: It is demonstrated that a mutator phenotype caused by a mismatch repair defect is prevalent in C. glabrata clinical isolates, and it is anticipated that identifying MSH2 defects in infecting strains may influence the management of patients on antifungal drug therapy.
Abstract: The fungal pathogen Candida glabrata readily acquires resistance to multiple types of antifungal drugs. Here, Healey et al. show that C. glabrata clinical isolates often carry mutations in a gene involved in DNA mismatch repair, and this is associated with increased propensity to develop antifungal resistance.
210 citations
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TL;DR: The BDI-II was administered to 130 psychiatric inpatients who were 55 years old or above and who were diagnosed with principal DSM-IV major depressive disorders (MDD) or adjustment disorders with depressed mood (N = 45, 35%).
210 citations
Authors
Showing all 14639 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Danny Reinberg | 145 | 342 | 68201 |
Michael F. Holick | 145 | 767 | 107937 |
Tasuku Honjo | 141 | 712 | 88428 |
Arnold J. Levine | 139 | 485 | 116005 |
Aaron T. Beck | 139 | 536 | 170816 |
Charles J. Yeo | 136 | 672 | 76424 |
Jerry W. Shay | 133 | 639 | 74774 |
Chung S. Yang | 128 | 560 | 56265 |
Paul G. Falkowski | 127 | 378 | 64898 |
Csaba Szabó | 123 | 958 | 61791 |
William C. Roberts | 122 | 1117 | 55285 |
Bryan R. Cullen | 121 | 371 | 50901 |
John R. Perfect | 119 | 573 | 52325 |