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Institution

University of Medicine and Dentistry of New Jersey

Education
About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Poison control. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.


Papers
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Journal ArticleDOI
TL;DR: It is proposed that the observed nonsense suppression phenotype in the upfΔ strains can be attributed to a defect in the surveillance complex assembly, which occurs during the premature translation termination process.
Abstract: The yeast UPF1, UPF2 and UPF3 genes encode trans-acting factors of the nonsense-mediated mRNA decay pathway. In addition, the upf1Δ strain demonstrates a nonsense suppression phenotype and Upf1p has been shown to interact with the release factors eRF1 and eRF3. In this report, we show that both upf2Δ and upf3Δ strains demonstrate a nonsense suppression phenotype independent of their effect on mRNA turnover. We also demonstrate that Upf2p and Upf3p interact with eRF3, and that their ability to bind eRF3 correlates with their ability to complement the nonsense suppression phenotype. In vitro experiments demonstrate that Upf2p, Upf3p and eRF1 compete with each other for interacting with eRF3. Con versely, Upf1p binds to a different region of eRF3 and can form a complex with these factors. These results suggest a sequential surveillance complex assembly pathway, which occurs during the premature translation termination process. We propose that the observed nonsense suppression phenotype in the upfΔ strains can be attributed to a defect in the surveillance complex assembly.

206 citations

Journal ArticleDOI
TL;DR: The tendency toward undermedication for pain is even more pronounced in children than in adults, and there are large discrepancies between the amounts of postoperative analgesia ordered for and administered to adults and those orders for and administer to children.
Abstract: It has long been recognized that patients receive less relief from pain than they should1,2. A recent review concluded that pain can be relieved effectively in 90 percent of patients but is not relieved effectively in 80 percent of patients3. The tendency toward undermedication for pain is even more pronounced in children than in adults4. There are large discrepancies between the amounts of postoperative analgesia ordered for and administered to adults and those ordered for and administered to children who have the same diagnoses and have undergone the same procedures5,6. Interest in pain control . . .

206 citations

Journal ArticleDOI
TL;DR: The high rate of age-dependent telomere attrition in the distal abdominal aorta probably reflects enhanced cellular turnover rate due to local factors such as an increase in shear wall stress in this vascular segment.

205 citations

Journal ArticleDOI
01 May 2001-Pain
TL;DR: The findings indicate that the relationship between childhood victimization and pain symptoms in adulthood is more complex than previously thought and the common assumption that medically unexplained pain is of psychological origin should be questioned.
Abstract: Evidence of the relationship between childhood abuse and pain problems in adulthood has been based on cross-sectional studies using retrospective self-reports of childhood victimization. The objective of the current study was to determine whether childhood victimization increases risk for adult pain complaints, using prospective information from documented cases of child abuse and neglect. Using a prospective cohort design, cases of early childhood abuse or neglect documented between 1967 and 1971 (n = 676) and demographically matched controls (n = 520) were followed into young adulthood. The number of medically explained and unexplained pain complaints reported at follow-up (1989-1995) was examined. Assessed prospectively, physically and sexually abused and neglected individuals were not at risk for increased pain symptoms. The odds of reporting one or more unexplained pain symptoms was not associated with any childhood victimization or specific types (i.e. sexual abuse, physical abuse, or neglect). In contrast, the odds of one or more unexplained pain symptoms was significantly associated with retrospective self-reports of all specific types of childhood victimization. These findings indicate that the relationship between childhood victimization and pain symptoms in adulthood is more complex than previously thought. The common assumption that medically unexplained pain is of psychological origin should be questioned. Additional research conducting comprehensive physical examinations with victims of childhood abuse and neglect is recommended.

205 citations

Journal ArticleDOI
TL;DR: It is found that for PC-12, HeLa and HT-29 cell lines as well as primary cultures of cardiac myocytes and neurons in vitro in differing media, approximately 5 nmol/L free zinc produced apparently healthy cells, but 20-fold higher or lower concentrations were usually harmful as judged by multiple criteria.
Abstract: The zinc(II) ion has recently been implicated in a number of novel functions and pathologies in loci as diverse as the brain, retina, small intestine, prostate, heart, pancreas, and immune system. ...

205 citations


Authors

Showing all 14639 results

NameH-indexPapersCitations
John Q. Trojanowski2261467213948
Virginia M.-Y. Lee194993148820
Danny Reinberg14534268201
Michael F. Holick145767107937
Tasuku Honjo14171288428
Arnold J. Levine139485116005
Aaron T. Beck139536170816
Charles J. Yeo13667276424
Jerry W. Shay13363974774
Chung S. Yang12856056265
Paul G. Falkowski12737864898
Csaba Szabó12395861791
William C. Roberts122111755285
Bryan R. Cullen12137150901
John R. Perfect11957352325
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20226
202113
20208
201917
201823
201736