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University of Medicine and Dentistry of New Jersey
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About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Pregnancy. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.
Topics: Population, Pregnancy, Poison control, Gene, Receptor
Papers published on a yearly basis
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TL;DR: It is indicated that pollution levels in households using solid fuel generally exceed China’s indoor air quality standards, and intervention technologies ranging from simply adding a chimney to the more complex modernized bioenergy program are available.
Abstract: Although some areas of China are becoming more urban, more than 60% of the population is still rural, most of which still uses biomass (mainly wood and crop residues) and coal fuels that produce substantial pollution in simple stoves. In 2003 approximately 80% of the energy consumed by rural households was in the form of biomass and almost 10% as coal. Furthermore, although most Chinese cities have plans to eliminate coal for households, many urban communities continue to rely on coal. The combustion of biomass and coal (collectively called “solid fuels”) is the dominant source of indoor air pollution (IAP) in the country and contributes significantly to the total burden of ill health.
In the most recent global analysis of the health effects of major risk factors, the World Health Organization (WHO) estimated that solid fuels used in Chinese households cause approximately 420,000 premature deaths annually; this is 40% more than the approximately 300,000 premature deaths attributed to outdoor air pollution in Chinese cities with populations of more than 100,000 (Cohen et al. 2004; Smith et al. 2004). Household use of solid fuels is thus estimated to be the largest single environmental risk factor and ranks sixth among all risk factors examined for ill-health (Figure 1; Smith et al. 2005). These risk estimates, however, were based primarily on studies in other countries because, as discussed in this review, few epidemiologic studies have been conducted in China on biomass smoke compared with those conducted on coal smoke.
Figure 1
Rough estimates of the burden of disease in China: the top 10 risk factors plus other selected risk factors [adapted from Smith et al. (2005)]. Note: Indoor smoke from solid fuels does not include smoke from other fuels or tobacco. Burden of disease is ...
In the 1980s China conducted more IAP measurements focused on household combustion than all other developing countries combined. Indeed, by the early 1990s, the results of more than 100 published studies were combined into a WHO database (Sinton et al. 1996). In contrast, the Chinese environmental health community conducted few IAP measurements in the 1990s (Saksena et al. 2003), but epidemiologic studies of coal smoke, mainly on cancer end points, continued and have resulted in a large body of evidence. In particular, over 25 years a wide-ranging set of studies has been conducted on coal smoke exposures, toxicology, and health effects in one rural area—Xuanwei in Yunnan Province—with severe impacts.
In this review we address the following questions in order to put Chinese household IAP from solid fuel use into perspective, nationally and internationally, and highlight research gaps: a) What toxic constituents have been found in the emissions of solid fuel combustion? b) What are the reported human exposure characteristics? c) What health effects have been documented? and d) What technologies exist or are possible for reducing this IAP exposure?
699 citations
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TL;DR: In vitro analyses and corroborating in vivo experiments demonstrate that elongation by RNA polymerase II through the nucleosomal barrier is minimally dependent upon FACT and the recruitment of PAF and the H2B monoubiquitination machinery.
686 citations
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TL;DR: Increasing amount of data suggest that AChRs and PPARs are involved in AD-induced neuroinflammation and in this regard, future therapy may focus on their specific targeting in the AD brain.
684 citations
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Harvard University1, University of Southern California2, University of Arkansas for Medical Sciences3, Boston Children's Hospital4, University of Colorado Denver5, New York University6, University of California, Davis7, Columbia University Medical Center8, Baylor College of Medicine9, State University of New York System10, Columbia University11, University of Rochester Medical Center12, Mahidol University13, University of Medicine and Dentistry of New Jersey14, Cleveland Clinic15, New York Academy of Medicine16, Children's Memorial Hospital17, University of California, Los Angeles18
TL;DR: The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.
Abstract: Autism spectrum disorders (ASDs) are common and clinically heterogeneous neurodevelopmental disorders. Gastrointestinal disorders and associated symptoms are commonly reported in individuals with ASDs, but key issues such as the prevalence and best treatment of these conditions are incompletely understood. A central difficulty in recognizing and characterizing gastrointestinal dysfunction with ASDs is the communication difficulties experienced by many affected individuals. A multidisciplinary panel reviewed the medical literature with the aim of generating evidence-based recommendations for diagnostic evaluation and management of gastrointestinal problems in this patient population. The panel concluded that evidence-based recommendations are not yet available. The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders. For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs.
682 citations
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TL;DR: Children with obese mothers, low family incomes, and lower cognitive stimulation have significantly elevated risks of developing obesity, independent of other demographic and socioeconomic factors.
Abstract: Context. Obesity is the most common health problem facing children. The most recent data from the National Health and Nutrition Examination Survey III suggest that 22% of children and adolescents are overweight and that 11% are obese. Objective. To investigate prospectively the association between the home environment and socioeconomic factors and the development of obesity in children. Design. Prospective cohort study. Setting. The National Longitudinal Survey of Youth. Population. A total of 2913 normal weight children between the ages of 0 and 8 years were followed over a 6-year period. We examined the roles of race, marital status, maternal education, family income, and parental occupation, as well as standardized measures of the home environment (The Home Observation for Measurement of the Environment [HOME]-Short Form) on the development of childhood obesity. Primary Outcome Measure. Incidence of obesity. Obesity was defined as a body mass index >95th percentile for age and gender at the 6-year follow-up. Results. Maternal obesity was the most significant predictor of childhood obesity (OR: 3.62 [2.65–4.96]). The HOME-Short Form cognitive scores and household income were also significant predictors of childhood obesity (OR, low HOME-cognitive: 2.64 [1.48–4.70], medium HOME-cognitive: 2.32 [1.39–3.88]; low income: 2.91 [1.66–5.08], medium income: 2.04 [1.21–3.44]). Children who lived with single mothers were also significantly more likely to become obese by the 6-year follow-up, as were black children, children with nonworking parents, children with nonprofessional parents, and children whose mothers did not complete high school. Neither the child9s gender nor the HOME-emotional scores contributed to the development of obesity. After controlling for the child9s initial weight-for-height z -score, maternal body mass index, race, marital status, occupation, education, and HOME emotional scores, only the HOME cognitive score and family income remained significant predictors of childhood obesity. Conclusion. Children with obese mothers, low family incomes, and lower cognitive stimulation have significantly elevated risks of developing obesity, independent of other demographic and socioeconomic factors. In contrast, increased rates of obesity in black children, children with lower family education, and nonprofessional parents may be mediated through the confounding effects of low income and lower levels of cognitive stimulation.
682 citations
Authors
Showing all 14639 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Danny Reinberg | 145 | 342 | 68201 |
Michael F. Holick | 145 | 767 | 107937 |
Tasuku Honjo | 141 | 712 | 88428 |
Arnold J. Levine | 139 | 485 | 116005 |
Aaron T. Beck | 139 | 536 | 170816 |
Charles J. Yeo | 136 | 672 | 76424 |
Jerry W. Shay | 133 | 639 | 74774 |
Chung S. Yang | 128 | 560 | 56265 |
Paul G. Falkowski | 127 | 378 | 64898 |
Csaba Szabó | 123 | 958 | 61791 |
William C. Roberts | 122 | 1117 | 55285 |
Bryan R. Cullen | 121 | 371 | 50901 |
John R. Perfect | 119 | 573 | 52325 |